By Sara Sjolin, MarketWatch

LONDON (MarketWatch) -- European stock markets posted broad-based losses on Wednesday, with banks leading the charge south, following a setback in the latest attempt to form a government in Italy.

The Stoxx Europe 600 index dropped 0.5% to close at 292.44, after opening in positive territory.

The index had earlier this week moved between small gains and losses, as contagion fears following a controversial Cyprus bailout and upbeat U.S. data battled to be the key driver for investors.

Wednesday's turnaround was sparked by comments from Italy's Democratic Party leader Pier Luigi Bersani, whose effort to win support for a center-left government from the anti-establishment Five-Star Movement fell on deaf ears. Bersani ruled out forming a grand coalition with Silvio Berlusconi's center-right alliance and said "only an insane person would want to govern this country, which is in a mess and faces a difficult year ahead."

The FTSE MIB index fell 0.9% to 15,353.85, with banks posting some of the biggest losses. Banca Popolare di Milano Scarl lost 3.4%, while UniCredit SpA dropped 0.6%.

"Italy had never really gone away, it was just muscled out of the spotlight by Cyprus," said James Ashley, senior European economist at RBC Capital Markets.

"The alternative to a coalition is a minority government and that does not strike me as a stable solution. Italy needs a strong government in the state it's in right now and needs someone to carry out reforms," he said.

Of further interest in Italy, the Treasury sold 6.91 billion euros ($8.8 billion) of debt, with five-year borrowing costs rising to a five-month high, according to Dow Jones Newswires.

On the euro-zone data front, the Economic Sentiment Indicator fell to 90.0 in March from 91.1, the first decline since October last year.

Most banking shares in Europe were mired in the red, following days of uncertainty over the stability of the Cyprus banking system. The island nation earlier in the week agreed to a bailout package including a haircut on many bank deposits above EUR100,000, fueling fears that the measures could set a precedent for solving future banking crises in other euro-zone countries.

Cypriot authorities were planning to reopen the country's banks on Thursday, but customers could find their access to money limited. The government planned to launch aggressive limits on the amount of cash that can be taken out of the country in efforts to avoid a bank run, The Wall Street Journal Reported. The Cyprus Stock Exchange was also closed for trading until Thursday. Read: Three ways for Europe to regain control of its crisis--Nomura.

"The immediate tail risks have been taken off the table after Cyprus agreed with the troika on the bailout program. The concern now is what happens when the banks reopen tomorrow," Ashley said.

"They are putting the capital controls in place for valid reasons, but it's against one of the key principles in the EU, free movement of capital. They hope to persuade people that their deposits are not at risk unless they are part of the bailout agreement and perhaps people will start to trust the banks and the government," he added.

Movers

Greece's ATHEX Composite sank 4% to 849.62, with shares of Hellenic Telecommunications Organization SA 9.4% lower. The company said that its deposits in three of the largest Cyprus banks amount to EUR3 million.

In Spain, shares of Banco Santander SA (SAN) dropped 1.1% and BBVA SA (BBVA) fell 0.4%. The IBEX 35 index closed 1.1% lower at 7,900.40.

In France, BNP Paribas SA slumped 1.7% and Société Générale SA fell 1%.

Also in Paris, shares of European Aeronautic Defence & Space Co. (EADSY) shed 3.1%, after French media group Lagardere SCA Chief Executive Arnaud Lagardère said in a report in the French daily Les Echos that the firm will sell its 7.5% stake in the Airbus owner. Lagardère fell 1.8%.

The CAC 40 index declined 1% to 3,711.64.

Germany's DAX 30 index fell 1.2% to 7,789.09. Shares of Allianz SE declined 2.3%, as the insurer said it would buy 94% of Yapi Kredi Sigorta, an insurance unit of Yapi Kredi, Turkey's fourth largest private bank by assets.

The U.K.'s FTSE 100 index moved 0.2% lower to 6,387.56, with energy firms tracking oil prices lower. Shares of BG Group PLC lost 1.5% and Royal Dutch Shell PLC (RDSB) dropped 0.5%.

U.S. stocks fell on Wall Street. Data showed pending-home sales declined 0.4% in February, although longer-term trends showed continuing growth.

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