4d Pharma PLC MRx0518 poster presentations at SITC 2022 (8490B)
05 Oktober 2022 - 2:00PM
UK Regulatory
TIDMDDDD
RNS Number : 8490B
4d Pharma PLC
05 October 2022
4D pharma Announces Two Presentations at The Society for
Immunotherapy of Cancer Annual Meeting (SITC 2022)
Leeds, UK - October 5, 2022 - 4D pharma plc (AIM: DDDD) (in
administration), a pharmaceutical company leading the development
of Live Biotherapeutic products (LBPs), a novel class of drug
derived from the microbiome, today announces two poster
presentations at the Society for Immunotherapy of Cancer's (SITC)
37th Annual Meeting (SITC 2022), held from November 8-12, 2022. The
two e-posters will be available from 2.00 pm GMT (9.00 am ET) on
November 10, 2022, via the 4D pharma website at
https://www.4dpharmaplc.com .
"With these two presentations at SITC 2022, 4D pharma continues
to generate clinical data deepening our understanding of the
mechanisms driving the activity of MRx0518 to both overcome
resistance to checkpoint inhibitors, and act as a monotherapy in
the treatment of solid tumors," commented Alex Stevenson, Chief
Scientific Officer, 4D pharma. "These data are further evidence of
the positive effects of a single strain Live Biotherapeutic on both
the human immune system and the microbiome, leading to better
treatment outcomes for patients."
Poster presentation details are as follows:
Presentation Title: Combination of MRx0518 and anti-PD-1
overcomes checkpoint inhibitor resistance via myeloid
modulation
Presenting Author: Dr. June Li, Research Scientist, Department
of Translational Molecular Pathology, The University of Texas MD
Anderson Cancer Center
Abstract Number: 838
Presentation Title: Oral administration of MRx0518 in
treatment-naïve cancer patients is associated with compositional
taxonomic and metabolomic changes indicative of anti-tumorigenic
efficacy
Presenting Author: Dr. Mark P. Lythgoe, Academic Clinical Fellow
in Medical Oncology and Pharmacist, Imperial College London
Abstract Number: 627
On 24 June 2022, David Pike and James Clark of Interpath
Advisory were appointed as administrators of 4D pharma plc. The
administrators have had no oversight of or involvement in the
preparation of the SITC 2022 poster presentations nor in any
materials which will be circulated in advance of or during SITC
2022. Therefore, the administrators make no statement or
representation in respect of the materials shared or discussed in
advance of or during SITC 2022.
About MRx0518
MRx0518 is single strain Live Biotherapeutic product in
development for the treatment of cancer. It is delivered as an oral
capsule and stimulates the body's immune system, directing it to
produce cytokines and immune cells that are known to attack tumors.
It is currently being evaluated in three clinical trials in cancer
patients. MRx0518-I-001 is a neoadjuvant monotherapy study in a
variety of solid tumors and is being conducted at Imperial College
(London, UK). MRx0518-I-002 is in combination with KEYTRUDA
(pembrolizumab) in patients who have previously progressed on anti
PD-1 therapies. The Coordinating Investigator of the study is at
The University of Texas MD Anderson Cancer Center, Houston, USA,
with multiple additional sites in the US. The study is being
conducted in collaboration with MSD, the tradename of Merck &
Co., Inc., Kenilworth, NJ, USA. MRx0518-I-003 is in combination
with preoperative radiotherapy in resectable pancreatic cancer. A
fourth clinical trial is planned, in collaboration with Merck KGaA
and Pfizer Inc., of BAVENCIO (avelumab) in combination with MRx0518
as a first-line maintenance therapy for patients with locally
advanced or metastatic urothelial carcinoma that has not progressed
with first-line platinum-containing chemotherapy.
About 4D pharma
4D pharma is a world leader in the development of Live
Biotherapeutics, a novel and emerging class of drugs, defined by
the FDA as biological products that contain a live organism, such
as a bacterium, that is applicable to the prevention, treatment or
cure of a disease. 4D has developed a proprietary platform,
MicroRx(R), that rationally identifies Live Biotherapeutics based
on a deep understanding of function and mechanism.
4D pharma's Live Biotherapeutic products (LBPs) are orally
delivered single strains of bacteria that are naturally found in
the healthy human gut. The Company has five clinical programs,
namely a Phase I/II study of MRx0518 in combination with KEYTRUDA
(pembrolizumab) in solid tumors, a Phase I study of MRx0518 in a
neoadjuvant setting for patients with solid tumors, a Phase I study
of MRx0518 in patients with pancreatic cancer, a Phase I/II study
of MRx-4DP0004 in asthma, and Blautix(R) in Irritable Bowel
Syndrome (IBS) which has completed a successful Phase II trial.
Preclinical-stage programs include candidates for CNS disease such
as Parkinson's disease and other neurodegenerative conditions. The
Company has a research collaboration with MSD, a tradename of Merck
& Co., Inc., Kenilworth, NJ, USA, to discover and develop Live
Biotherapeutics for vaccines.
For more information, refer to https://www.4dpharmaplc.com
Contact Information:
4D pharma
4dpharma@interpathadvisory.com
Singer Capital Markets - Nominated Adviser and Joint Broker
Philip Davies / James Fischer (Corporate Finance) +44 (0)20 7496
3000
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