FORM 4
☒ Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Zhou Jing		 2. Issuer Name and Ticker or Trading Symbol

IsoPlexis Corp [ ISO ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Chief Scientific Officer
(Last)          (First)          (Middle)

C/O ISOPLEXIS CORPORATION, 35 NE INDUSTRIAL ROAD		 3. Date of Earliest Transaction (MM/DD/YYYY)

3/21/2023
(Street)

BRANFORD, CT 06405		 4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
 6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)        (State)        (Zip)
Rule 10b5-1(c) Transaction Indication
☐ Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 3/21/2023  D  1200 D (1)0 I By Spouse IRA 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option $0.2788 3/21/2023  D     8000   (3)10/18/2025 Common Stock 8000  (2)0 D  
Stock Option $0.2788 3/21/2023  D     1600   (4)12/31/2025 Common Stock 1600  (2)0 D  
Stock Option $0.4775 3/21/2023  D     4000   (5)1/30/2027 Common Stock 4000  (2)0 D  
Stock Option $0.7263 3/21/2023  D     22000   (6)10/24/2027 Common Stock 22000  (2)0 D  
Stock Option $0.9625 3/21/2023  D     8000   (7)12/13/2028 Common Stock 8000  (2)0 D  
Stock Option $1.0275 3/21/2023  D     30000   (8)12/3/2029 Common Stock 30000  (2)0 D  
Stock Option $1.83 3/21/2023  D     12000   (9)12/14/2030 Common Stock 12000  (2)0 D  
Stock Option $4.81 3/21/2023  D     100000   (10)6/7/2031 Common Stock 100000  (2)0 D  
Stock Option $3.43 3/21/2023  D     73500   (11)3/31/2032 Common Stock 73500  (2)0 D  
Explanation of Responses:
(1) On March 21, 2023, pursuant to the Agreement and Plan of Merger, dated as of December 21, 2022 (the Merger Agreement), by and among IsoPlexis Corporation, a Delaware corporation (IsoPlexis), Berkeley Lights, Inc., a Delaware corporation (Berkeley Lights), and Iceland Merger Sub Inc., a Delaware corporation and a wholly owned subsidiary of Berkeley Lights, each share of common stock, par value $0.001, of IsoPlexis (IsoPlexis Common Stock) reported in this Form 4 was converted into the right to receive 0.6120 fully paid and nonassessable shares of common stock, par value $0.00005, of Berkeley Lights (Berkeley Lights Common Stock), together with cash in lieu of fractional shares of Berkeley Lights Common Stock, if any, and any unpaid dividends or other distributions.
(2) On March 21, 2023, pursuant to the Merger Agreement, each IsoPlexis stock option (whether vested or unvested) reported in this Form 4 (a) if the per-share exercise price was equal to or greater than the average closing trading price for a share of IsoPlexis Common Stock rounded to the nearest one-tenth of a cent, as reported on The Nasdaq Stock Market LLC for the five most recent trading days ending on and including the third business day prior to March 20, 2023 (the Company Trading Price), was canceled for no consideration and (b) if the per-share exercise price was less than the Company Trading Price, was converted into a Berkeley Lights stock option of approximately equivalent value and generally on the same terms and conditions.
(3) Vested 25% on October 29, 2016 and thereafter in 36 equal monthly installments.
(4) Vested 25% on January 1, 2017 and thereafter in 36 equal monthly installments.
(5) Vested 25% on January 31, 2018 and thereafter in 36 equal monthly installments.
(6) Vested 25% on October 25, 2018 and thereafter in 36 equal monthly installments.
(7) Vested 25% on December 5, 2019 and thereafter in 36 equal monthly installments.
(8) Vested 25% on December 4, 2020 and thereafter in 36 equal monthly installments.
(9) Vested 25% on December 15, 2021 and thereafter in 36 equal monthly installments.
(10) Vested 25% on June 8, 2022 and thereafter in 36 equal monthly installments.
(11) Vests 25% on March 31, 2023 and thereafter in 36 equal monthly installments.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Zhou Jing
C/O ISOPLEXIS CORPORATION
35 NE INDUSTRIAL ROAD
BRANFORD, CT 06405

Chief Scientific Officer
Signatures
/s/ Jing Zhou3/21/2023
**Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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