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144: Remarks and Signature

Remarks

Date of Notice

11/12/2024

Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1

08/13/2024

ATTENTION:

The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.

Signature

/s/ Dominick Iadicicco, as a duly authorized representative of STIFEL, as attorney-in-fact for Joseph Loscalzo

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IONS Ionis Pharmaceuticals Inc

144: Remarks and Signature

ATTENTION:

ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)

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IONS Ionis Pharmaceuticals Inc

144: Remarks and Signature

ATTENTION:

ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)

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