FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Ross Michael Jay 		2. Issuer Name and Ticker or Trading Symbol

Arsanis, Inc. [ ASNS ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__ X __ Director                      __ X __ 10% Owner
_____ Officer (give title below)      _____ Other (specify below)
(Last)          (First)          (Middle)

C/O SV HEALTH INVESTORS ONE BOSTON PLACE, SUITE 3900, 201 WASHINGTON STREET 		3. Date of Earliest Transaction (MM/DD/YYYY)

11/20/2017
(Street)

BOSTON, MA 02108
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock   11/20/2017     C    19128   A   (1) 19128   I   See Footnote   (6)
Common Stock   11/20/2017     C    404   A   (1) 19532   I   See Footnote   (7)
Common Stock   11/20/2017     C    247010   A   (2) 266542   I   See Footnote   (6)
Common Stock   11/20/2017     C    5219   A   (2) 271761   I   See Footnote   (7)
Common Stock   11/20/2017     C    322102   A   (3) 593863   I   See Footnote   (6)
Common Stock   11/20/2017     C    6806   A   (3) 600669   I   See Footnote   (7)
Common Stock   11/20/2017     C    111955   A   (4) 712624   I   See Footnote   (6)
Common Stock   11/20/2017     C    2365   A   (4) 714989   I   See Footnote   (7)
Common Stock   11/20/2017     C    202915   A   (5) 917904   I   See Footnote   (6)
Common Stock   11/20/2017     C    4288   A   (5) 922192   I   See Footnote   (7)
Common Stock   11/20/2017     C    431980   A   (5) 1354172   I   See Footnote   (8)
Common Stock   11/20/2017     C    14789   A   (5) 1368961   I   See Footnote   (9)
Common Stock   11/20/2017     P    483448   A $10.00   1852409   I   See Footnote   (8)
Common Stock   11/20/2017     P    16552   A $10.00   1868961   I   See Footnote   (9)

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series A-1 Convertible Preferred Stock     (1) 11/20/2017     C         65287      (1)   (1) Common Stock   19128   $0.00   0   I   See Footnote   (6)
Series A-1 Convertible Preferred Stock     (1) 11/20/2017     C         1380      (1)   (1) Common Stock   404   $0.00   0   I   See Footnote   (7)
Series A-2 Convertible Preferred Stock     (2) 11/20/2017     C         690259      (2)   (2) Common Stock   247010   $0.00   0   I   See Footnote   (6)
Series A-2 Convertible Preferred Stock     (2) 11/20/2017     C         14587      (2)   (2) Common Stock   5219   $0.00   0   I   See Footnote   (7)
Series B Convertible Preferred Stock     (3) 11/20/2017     C         721402      (3)   (3) Common Stock   322102   $0.00   0   I   See Footnote   (6)
Series B Convertible Preferred Stock     (3) 11/20/2017     C         15246      (3)   (3) Common Stock   6806   $0.00   0   I   See Footnote   (7)
Series C Convertible Preferred Stock     (4) 11/20/2017     C         224665      (4)   (4) Common Stock   111955   $0.00   0   I   See Footnote   (6)
Series C Convertible Preferred Stock     (4) 11/20/2017     C         4747      (4)   (4) Common Stock   2365   $0.00   0   I   See Footnote   (9)
Series D Convertible Preferred Stock     (5) 11/20/2017     C         692552      (5)   (5) Common Stock   202915   $0.00   0   I   See Footnote   (6)
Series D Convertible Preferred Stock     (5) 11/20/2017     C         14635      (5)   (5) Common Stock   4288   $0.00   0   I   See Footnote   (7)
Series D Convertible Preferred Stock     (5) 11/20/2017     C         1474348      (5)   (5) Common Stock   431980   $0.00   0   I   See Footnote   (8)
Series D Convertible Preferred Stock     (5) 11/20/2017     C         50477      (5)   (5) Common Stock   14789   $0.00   0   I   See Footnote   (9)

Explanation of Responses:
(1)  The Series A-1 Convertible Preferred Stock converted into Common Stock on a 0.29300-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-1 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date.
(2)  The Series A-2 Convertible Preferred Stock converted into Common Stock on a 0.35785-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-2 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date.
(3)  The Series B Convertible Preferred Stock converted into Common Stock on a 0.44650-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series B Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date.
(4)  The Series C Convertible Preferred Stock converted into Common Stock on a 0.49832-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series C Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date.
(5)  The Series D Convertible Preferred Stock converted into Common Stock on a 0.29300-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series D Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date.
(6)  These shares are owned directly by SV Life Sciences Fund V, L.P. ("SVLS V LP"). SV Life Sciences Fund V (GP), LP ("SVLS V GP") is the general partner of SVLS V LP. The general partner of SVLS V GP is SVLSF V, LLC. The reporting person, a member of the investment committee of SVLSF V, LLC, may be deemed to share voting, dispositive and investment power over the shares held of record by SVLS V LP. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein.
(7)  These shares are owned directly by SV Life Sciences Fund V Strategic Partners, L.P. ("SVLS V SPP"). SVLS V GP is the general partner of SVLS V SPP. The general partner of SVLS V GP is SVLSF V, LLC. The reporting person, a member of the investment committee of SVLSF V, LLC, may be deemed to share voting, dispositive and investment power over the shares held of record by SVLS V LP. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein.
(8)  These shares are owned directly by SV Life Sciences Fund VI, L.P. ("SVLS VI LP"). SV Life Sciences Fund VI (GP), LP ("SVLS VI GP") is the general partner of SVLS VI LP. The general partner of SVLS VI GP is SVLSF VI, LLC. The reporting person, a member of the investment committee of SVLSF VI, LLC, may be deemed to share voting, dispositive and investment power over the shares held of record by SVLS V LP. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein.
(9)  These shares are owned directly by SV Life Sciences Fund VI Strategic Partners, L.P. ("SVLS VI SPP"). SVLS VI GP is the general partner of SVLS VI SPP. The general partner of SVLS VI GP is SVLSF VI, LLC. The reporting person, a member of the investment committee of SVLSF VI, LLC, may be deemed to share voting, dispositive and investment power over the shares held of record by SVLS V LP. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Ross Michael Jay
C/O SV HEALTH INVESTORS ONE BOSTON PLACE
SUITE 3900, 201 WASHINGTON STREET
BOSTON, MA 02108 		X X


Signatures
/s/ Mike Gray, attorney-in-fact 11/20/2017
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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