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Explanation of Responses:
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1)
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On May 3, 2016, the issuer and Quintiles Transnational Holdings, Inc. ("Quintiles") entered into an Agreement and Plan of Merger pursuant to which on October 3, 2016 the issuer merged with and into Quintiles (the "merger"), the separate existence of the issuer ceased and Quintiles will continue as the surviving corporation, operating under the name Quintiles IMS Holdings, Inc.
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2)
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On February 10, 2015, the reporting person was granted 80,289 performance-based restricted stock units. The shares are earned based on the company's financial results over a three-year period (January 1, 2015 - December 31, 2017). In connection with the merger and based on the performance criteria achieved, 95,704 shares of issuer common stock were issued to the recipient. The performance-based restricted stock unit was assumed by Quintiles in the merger and replaced with a time-based restricted stock unit of 36,750 shares of Quintiles IMS Holdings, Inc. stock having a market value of $81.06 per share at the effective time of the merger. The shares will vest on December 31, 2017.
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3)
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On February 2, 2016, the reporting person was granted 108,412 performance-based restricted stock units. The shares are earned based on the company's financial results over a three-year period (January 1, 2016 - December 31, 2018). In connection with the merger and based on the performance criteria achieved, 149,283 shares of issuer common stock were issued to the recipient. The performance-based restricted stock unit was assumed by Quintiles in the merger and replaced with a time-based restricted stock unit of 57,324 shares of Quintiles IMS Holdings, Inc. stock having a market value of $81.06 per share at the effective time of the merger. The shares will vest on December 31, 2018.
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4)
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Disposed of pursuant to merger agreement in exchange for 736,177 shares of Quintiles IMS Holdings, Inc. stock having a market value of $81.06 per share at the effective time of the merger.
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5)
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Disposed of pursuant to merger agreement in exchange for 543,302 shares of Quintiles IMS Holdings, Inc. stock having a market value of $81.06 per share at the effective time of the merger.
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6)
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Shares held in Orohena Trust.
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7)
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This option was assumed by Quintiles in the merger and replaced with an option to purchase 192,000 shares of Quintiles IMS Holdings, Inc. common stock at a price of $28.13 per share.
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8)
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This option was assumed by Quintiles in the merger and replaced with an option to purchase 192,000 shares of Quintiles IMS Holdings, Inc. common stock at a price of $21.36 per share.
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9)
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This option was assumed by Quintiles in the merger and replaced with an option to purchase 460,800 shares of Quintiles IMS Holdings, Inc. common stock at a price of $26.05 per share.
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10)
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This option was assumed by Quintiles in the merger and replaced with an option to purchase 230,400 shares of Quintiles IMS Holdings, Inc. common stock at a price of $15.11 per share.
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11)
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This option was assumed by Quintiles in the merger and replaced with an option to purchase 460,800 shares of Quintiles IMS Holdings, Inc. common stock at a price of $8.34 per share.
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12)
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This stock appreciation right was assumed by Quintiles in the merger and replaced with a stock appreciation right to purchase 20,711 shares of Quintiles IMS Holdings, Inc. common stock at a price of $65.16 per share.
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13)
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This stock appreciation right vests in three annual installments beginning on February 10, 2017.
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14)
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This stock appreciation right was assumed by Quintiles in the merger and replaced with a stock appreciation right to purchase 62,136 shares of Quintiles IMS Holdings, Inc. common stock at a price of $65.16 per share.
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15)
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This stock appreciation right vests in four annual installments beginning on February 2, 2017.
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16)
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This stock appreciation right was assumed by Quintiles in the merger and replaced with a stock appreciation right to purchase 127,592 shares of Quintiles IMS Holdings, Inc. common stock at a price of $59.90 per share.
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