FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

TULLIS JAMES L L		 2. Issuer Name and Ticker or Trading Symbol

Alphatec Holdings, Inc. [ ATEC ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                    _____ 10% Owner
_____ Officer (give title below)    _____ Other (specify below)
(Last)          (First)          (Middle)

C/O ALPHATEC SPINE, INC., 1950 CAMINO VIDA ROBLE		 3. Date of Earliest Transaction (MM/DD/YYYY)

4/7/2022
(Street)

CARLSBAD, CA 92008
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
 6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 4/7/2022  X  6052 A$3.5 163142 D  
Common Stock 4/7/2022  S(1)  1630 D$12.99 161512 D  
Common Stock 4/7/2022  X  105708 A$3.5 576455 I By Tullis Growth Fund, L.P. 
Common Stock 4/7/2022  S(2)  28481 D$12.99 547974 I By Tullis Growth Fund, L.P. 
Common Stock 4/7/2022  X  145522 A$3.5 1036815 I By Tullis Dickerson Capital Focus III, LP 
Common Stock 4/7/2022  S(3)  39209 D$12.99 997606 I By Tullis Dickerson Capital Focus III, LP 
Common Stock         248225 I By Tullis-Dickerson Partners III, LLC 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Warrants (right to buy) $3.5 4/7/2022  X     6052   (4) (4)Common Stock 6052 $0 12286 D  
Warrants (right to buy) $3.5 4/7/2022  X     105708   (4) (4)Common Stock 105708 $0 214618 I By Tullis Growth Fund, L.P. 
Warrants (right to buy) $3.5 4/7/2022  X     145522   (4) (4)Common Stock 145522 $0 295451 I By Tullis Dickerson Capital Focus III, LP 
Explanation of Responses:
(1) On April 7, 2022, the reporting person exercised warrants to purchase 6,052 shares of the issuer's common stock for $3.50 per share. The reporting person paid the exercise price on a cashless basis, resulting in the issuer withholding 1,630 of the warrant shares to pay the exercise price and issuing to the reporting person 4,422 shares.
(2) On April 7, 2022, Tullis Growth Fund, L.P. exercised warrants to purchase 105,708 shares of the issuer's common stock for $3.50 per share. Tullis Growth Fund, L.P. paid the exercise price on a cashless basis, resulting in the issuer withholding 28,481 of the warrant shares to pay the exercise price and issuing to Tullis Growth Fund, L.P. 77,227 shares.
(3) On April 7, 2022, Tullis Dickerson Capital Focus III, LP exercised warrants to purchase 145,522 shares of the issuer's common stock for $3.50 per share. Tullis Dickerson Capital Focus III, LP paid the exercise price on a cashless basis, resulting in the issuer withholding 39,209 of the warrant shares to pay the exercise price and issuing to Tullis Dickerson Capital Focus III, LP 106,313 shares.
(4) Each Warrant is exercisable for one share of the issuer's common stock for a period of five years following the date that stockholder approval of the issuance of the Warrants was obtained. The stockholders approved such issuance on May 17, 2018.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
TULLIS JAMES L L
C/O ALPHATEC SPINE, INC.
1950 CAMINO VIDA ROBLE
CARLSBAD, CA 92008		X
Signatures
/s/ James L.L. Tullis4/11/2022
**Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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