VRAI Virtus Real Asset Income ETF

Stradley Ronon Stevens & Young, LLP   Suite 2600   2005 Market Street   Philadelphia, PA  19103-7018   Telephone  215.564.8000   Fax  215.564.8120   www.stradley.com

JCorriero@stradley.com
(215) 564-8528

March 4, 2020

VIA EDGAR TRANSMISSION

Filing Desk

U.S. Securities and Exchange Commission

100 F Street, NE

Washington, DC 20549

Ladies and Gentlemen:

Pursuant to Rule 497(j) under the Securities Act of 1933, this letter serves as certification that the forms of Prospectuses and Statements of Additional Information relating to the InfraCap MLP ETF, InfraCap REIT Preferred ETF, Virtus InfraCap U.S. Preferred Stock ETF, Virtus LifeSci Biotech Clinical Trials ETF, Virtus LifeSci Biotech Products ETF, Virtus Private Credit Strategy ETF, Virtus Real Asset Income ETF, Virtus WMC Global Factor Opportunities ETF and Virtus WMC Risk-Managed Alternative Equity ETF series of the Trust that would have been filed under paragraph (c) of Rule 497 would not have differed from those filed in Post-Effective Amendment No. 160, Amendment No. 161 (the “Amendment”), to the Trust’s Registration Statement on Form N-1A. The Amendment was filed with the U.S. Securities and Exchange Commission electronically on February 28, 2020 (Accession No. 0001387131-20-002347).

If you have any questions or comments regarding this filing, please call me at the above number, or in my absence, Michael D. Mabry at (215) 564-8011.

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