ReadCoor Receives Grant from Chan Zuckerberg Initiative
03 Januar 2018 - 1:00PM
Business Wire
Research to map spatial distributions of cell
types for the Human Cell Atlas
ReadCoor, Inc., a company reinventing omics and pathology with
its panomic spatial sequencing platform, today announced a grant
from the Chan Zuckerberg Initiative (CZI) and DAF, an advised fund
of Silicon Valley Community Foundation, to spatially map cortical
cells using Fluorescent in situ Sequencing (FISSEQ) for the Human
Cell Atlas.
The collaboration’s goal is to benchmark in situ technologies
and establish best practices for the Human Cell Atlas. The atlas
will contain in depth variance maps of cell transcriptomes,
genomes, proteomes, metabolomes, and epigenetic landscapes. FISSEQ
will provide deep insight into cell variation in the context of the
tissue microenvironment, a feature that is difficult or impossible
to obtain with traditional in situ methods. FISSEQ also uniquely
delivers researchers an opportunity to locate genes that have
mutated away from the original sequence due to its ability to
produce reads without known gene targets. Most standard in situ
methods are blind to such changes and can miss altered genes.
The research project is part of an Allen Institute-led
consortium of world-class research institutions. Members include
the Allen Institute for Brain Science (Ed Lein and Hongkui Zeng),
Broad Institute (Aviv Regev, Evan Macosko and Fei Chen), California
Institute of Technology (Long Cai and Barbara Wold), Cold Spring
Harbor Laboratory (Anthony Zador), Harvard University (George
Church, Paola Arlotta and Xiaowei Zhuang), Karolinska Institute
(Sten Linnarsson), KTH Royal Institute of Technology (Joakim
Lundeberg), Massachusetts Institute of Technology (Ed Boyden),
Stockholm University (Mats Nilsson), and the University of
California, San Diego (Kun Zhang). The ReadCoor team is led by
Samuel A. Inverso.
“Our team is honored to be part of this consortium of
world-leading academic scientists to contribute to the Human Cell
Atlas,” said Shawn Marcell, Chief Executive Officer of ReadCoor.
“We look forward to working with our fellow collaborators to
deliver a robust map of cortical cells and transcend our
foundational understanding of health and disease.”
About Fluorescent in situ Sequencing (FISSEQ)
FISSEQ is a spatial sequencing technology that reads and
visualizes the three-dimensional coordinates of molecules of intact
tissue, a capability that stands to revolutionize panomics and
pathology. FISSEQ was developed in the Church Lab at Harvard
University and the Wyss Institute for Biologically Inspired
Engineering, and first published in Science in 2014 (Highly
multiplexed three-dimensional subcellular transcriptome sequencing
in situ). The platform has broad application in the areas of drug
development, diagnostics, and machine learning.
About ReadCoor, Inc.
ReadCoor is leading the next generation of omics by delivering
the first panomic spatial sequencing platform to the global
audience of researchers, clinicians, pharma and diagnostics
companies, and ultimately patients. It is accomplishing this with
Fluorescent in situ Sequencing (FISSEQ), a fundamental new
technology, which simultaneously integrates high-throughput
sequencing, and three-dimensional morphometric analysis. This
uniquely powerful platform is expected to revolutionize the next
phase in understanding the panomic landscape and introduce vast new
opportunities for important and meaningful clinical insight.
About the Allen Institute for Brain Science
The Allen Institute for Brain Science is a division of the Allen
Institute (alleninstitute.org), an independent, 501(c)(3) nonprofit
medical research organization, and is dedicated to accelerating the
understanding of how the human brain works in health and disease.
Using a big science approach, the Allen Institute generates useful
public resources used by researchers and organizations around the
globe, drives technological and analytical advances, and discovers
fundamental brain properties through integration of experiments,
modeling and theory. Launched in 2003 with a seed contribution from
founder and philanthropist Paul G. Allen, the Allen Institute is
supported by a diversity of government, foundation and private
funds to enable its projects. The Allen Institute for Brain
Science’s data and tools are publicly available online
at brain-map.org.
About the Chan Zuckerberg Initiative
The Chan Zuckerberg Initiative was launched in December 2015 by
Mark Zuckerberg, founder and CEO of Facebook, and his wife,
Priscilla Chan, a pediatrician and founder and CEO of The Primary
School in East Palo Alto. The Chan Zuckerberg Initiative is a new
kind of philanthropic organization dedicated to advancing human
potential and promoting equal opportunity through world class
engineering, grantmaking, impact investing, policy, and advocacy
work. Initial areas of focus include supporting science through
basic biomedical research and education through personalized
learning. CZI is also exploring ways to build stronger, more
equitable communities through affordable housing and criminal
justice reform.
View source
version on businesswire.com: http://www.businesswire.com/news/home/20180103005105/en/
ReadCoor, Inc.Christine Lafontant,
617-453-2659christine.lafontant@readcoor.com