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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(D)
OF THE SECURITIES EXCHANGE ACT
OF 1934
Date of Report (Date of earliest
event reported): August 14, 2023
Zura
Bio Limited
(Exact name of registrant
as specified in its charter)
Cayman Islands |
|
001-40598 |
|
98-1725736 |
(State or other jurisdiction
of incorporation) |
|
(Commission
File Number) |
|
(I.R.S. Employer
Identification No.) |
1489 W. Warm Springs Rd. #110
Henderson, NV 89014
(Address of principal executive
offices, including zip code)
(702) 757-6133
(Registrant’s telephone
number, including area code)
(Former name or former address,
if changed since last report)
Check the appropriate box below if the Form 8-K
filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
| ¨ | Written
communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
| ¨ | Soliciting
material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
| ¨ | Pre-commencement
communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
| ¨ | Pre-commencement
communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Securities registered pursuant to Section 12(b) of the Act:
Title of each class |
|
Trading Symbol(s) |
|
Name
of each exchange on which registered |
Class A Ordinary Shares, par value $0.0001 per share |
|
ZURA |
|
The Nasdaq Stock Market |
Warrants, each whole warrant exercisable for one Class A Ordinary Share at an exercise price of $11.50 per share |
|
ZURAW |
|
The Nasdaq Stock Market |
Indicate by check mark whether
the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule
12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company x
If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 13(a) of the Exchange Act.
Item 2.02. | Results of Operations and Financial Condition. |
On August 14, 2023, Zura Bio Limited (the “Company”) issued
a press release announcing its second quarter 2023 results. A copy of the press release is furnished herewith as Exhibit 99.1 and incorporated
herein by reference.
The information in this Item 2.02 shall not be deemed “filed”
for purposes of Section 18 of the Securities Exchange Act of 1934, nor shall it be deemed incorporated by reference in any Company filing
under the Securities Act of 1933 or the Securities Exchange Act of 1934, except as shall be expressly set forth by specific reference
in such filing.
Item 9.01 |
Financial Statements and Exhibits. |
(d) Exhibits.
SIGNATURES
Pursuant to the requirements
of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.
Dated: August 14, 2023
ZURA BIO LIMITED |
|
|
|
|
By: |
/s/ Kim Davis |
|
|
Kim Davis |
|
|
Chief Legal Officer |
|
Exhibit 99.1
Zura Bio Reports Second Quarter 2023 Financial Results and Recent
Business Highlights
• | Focused on advancing ZB-106, a potential first-in-class anti-IL-17 and anti-BAFF dual antagonist for
systemic sclerosis and hidradenitis suppurativa |
| |
• | Experienced team building the next immunology leader |
| |
• | Cash and cash equivalents of $113 million support development and operations through 2026 |
Henderson, NV - August 14, 2023 - Zura
Bio Limited (Nasdaq: ZURA) (“Zura Bio” or the “Company”), a multi-asset clinical-stage biotechnology company
focused on developing novel medicines for immune and inflammatory disorders, today announced its financial results for the second quarter
ended June 30, 2023, and recent business highlights.
“Zura Bio made great progress in the first
half of 2023, and we look forward to advancing our multi-asset pipeline which includes our lead asset, ZB-106, also known as tibulizumab.
This is a Phase 2 ready dual antagonist of the IL-17 and BAFF pathways that will be explored in systemic sclerosis and hidradenitis suppurativa,
where inhibition of both IL-17 and BAFF have independently shown clinical efficacy,” said Dr. Someit Sidhu, Chief Executive
Officer of Zura Bio.
“Our team is focused on progressing ZB-106
for systemic sclerosis, followed by clinical trials in hidradenitis suppurativa where there is clinical validation of both IL-17 and B-cell
targeted therapies. Beyond ZB-106, we are very excited about the potential of ZB-168, an anti-IL-7Rα inhibitor that has the potential
to impact diseases driven by IL-7 and TSLP biological pathways, and ZB-880, a fully human, high affinity monoclonal antibody that neutralizes
IL-33.”
Second Quarter 2023 Business Highlights
• | Licensed
ZB-106 (tibulizumab), a potential first-in-class, anti-IL-17 and anti-BAFF dual antagonist
from Eli Lilly and Company (Press Release, April 27, 2023) |
| |
• | Completed
an approximate $80 million private placement led by Deep Track Capital, Great Point
Partners, Suvretta Capital, and other leading life sciences-focused investors (Press
Release, June 6, 2023) |
| |
• | Appointed
Michael D. Howell, Ph.D. to the role of Chief Scientific Officer and Head of Translational
Science (Press Release, April 14, 2023) |
| |
• | Joined
the Russell 2000® and Russell 3000® Indexes (Press Release, June 23,
2023) |
Second Quarter 2023 Financial Highlights
Cash
and cash equivalents: Cash and cash equivalents were $112.8 million as of June 30, 2023, as compared to $1.6 million as
of December 31, 2022. The increased cash balance is primarily due to the aggregate of capital raised from two private placement transactions
in March and April 2023. The Company anticipates that its cash and cash equivalents are sufficient to fund its planned operations
through 2026.
Research
and Development (R&D) expenses: R&D expenses were $28.2 million for the second quarter ended June 30, 2023, compared
to $0.1 million for the second quarter ended June 30, 2022. The increase was primarily due to expenses related to the acquisition
of ZB-106 from Eli Lilly and Company.
General
and Administrative (G&A) expenses: G&A expenses were $5.7 million for the second quarter ended June 30, 2023,
compared to $0.8 million for the second quarter ended June 30, 2022. This increase was primarily due to additional compensation for
personnel in executive functions and increased legal and accounting costs related to a second quarter private placement transaction and
ongoing operations as a public company.
Important upcoming anticipated events for Zura Bio
ZB-106
(tibulizumab): Initiate Phase 2 trials of ZB-106, an anti-IL-17 and anti-BAFF dual antagonist, for the treatment of systemic
sclerosis and hidradenitis suppurativa in 2H-2024.
ZB-168:
Initiate Phase 2 trial of ZB-168, an anti-IL-7Rα inhibitor, in 2024. Pending Phase 2 external catalysts in ulcerative colitis, atopic
dermatitis and additional TSLP driven catalysts.
ZB-880
(torudokimab): Prepare to initiate Phase 2 trial of ZB-880, an anti-IL-33 antibody, for the treatment of asthma in 2024. Pending
Phase 2 and Phase 3 external catalysts in asthma and chronic obstructive pulmonary disease.
Members of the Zura Bio team will participate
in the following upcoming conferences in the second half of 2023:
• | Stifel 2023 Immunology and Inflammation Virtual Summit: September 10 - 20, 2023 |
| |
• | Guggenheim Securities 5th Annual Inflammation & Immunology Conference: November 6 - 7, 2023 |
| |
• | Evercore ISI HealthCONx Conference: November 28 - 30, 2023 |
About Zura Bio
Zura Bio is a multi-asset clinical-stage biotechnology
company focused on developing novel medicines for immune and inflammatory disorders. Currently, Zura Bio is developing three assets which
have completed Phase 1/1b studies and are Phase 2 ready. The company is developing a portfolio of therapeutic indications for ZB-106 (tibulizumab),
ZB-168, and ZB-880 (torudokimab) with a goal of demonstrating their efficacy, safety, and dosing convenience in immune and inflammatory
disorders, including systemic sclerosis, hidradenitis suppurativa, and other novel indications with unmet needs.
About tibulizumab
ZB-106 (tibulizumab) is a potential first-in-class,
anti-IL-17 and anti-BAFF dual antagonist that Zura Bio plans to develop for the treatment of systemic sclerosis and hidradenitis suppurativa.
ZB-106 is an IgG-scFv bispecific dual-antagonist
antibody engineered by the fusion of Taltz® (ixekizumab) and tabalumab that neutralizes IL-17A and BAFF.
ZB-106 has been assessed in two Phase 1b studies
completed in rheumatoid arthritis and Sjögren's syndrome. The safety profile to date appears to be acceptable, with no new findings
relative to known IL-17 and BAFF inhibitors. Chronic toxicology studies have been completed with no adverse drug-related findings.
Clinical trials of ZB-106 in systemic sclerosis
and hidradenitis suppurativa are planned to begin in 2H-2024.
Forward Looking Statements Disclaimer
This communication includes “forward-looking
statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995.
Words such as “expect,” “estimate,” “project,” “budget,” “forecast,” “anticipate,”
“intend,” “plan,” “may,” “will,” “could,” “should,” “believe,”
“predict,” “potential,” “continue,” “strategy,” “future,” “opportunity,”
“would,” “seem,” “seek,” “outlook” and similar expressions are intended to identify such
forward-looking statements. Forward-looking statements are predictions, projections and other statements about future events that are
based on current expectations and assumptions and, as a result, are subject to risks and uncertainties that could cause the actual results
to differ materially from the expected results. These statements are based on various assumptions, whether or not identified in this communication.
These forward-looking statements are provided for illustrative purposes only and are not intended to serve as, and must not be relied
on by an investor as, a guarantee, an assurance, a prediction or a definitive statement of fact or probability.
Actual events and circumstances are difficult
or impossible to predict and will differ from assumptions. You should carefully consider the risks and uncertainties described in the
“Risk Factors” sections of Zura Bio’s recent filings with the SEC. These filings would identify and address other
important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking
statements. Many of these factors are outside Zura Bio’s control and are difficult to predict. Many factors could cause actual future
events to differ from the forward-looking statements in this communication, including but not limited to: (1) the outcome of any
legal proceedings that may be instituted against Zura Bio; (2) volatility in the price of Zura Bio’s securities; (3) the
ability of Zura Bio to successfully conduct research and development activities, grow and manage growth profitably, maintain relationships
with customers and suppliers, and retain key employees; (4) the ongoing costs relating to operating as a public company; (5) changes
in the applicable laws or regulations; (6) the possibility that Zura Bio may be adversely affected by other economic, business, and/or
competitive factors; (7) the risk of downturns and a changing regulatory landscape in the highly competitive industry in which Zura
Bio operates; (8) the potential inability of Zura Bio to raise additional capital needed to pursue its business objectives or to
achieve efficiencies regarding other costs; (9) the enforceability of Zura Bio’s intellectual property, including its patents,
and the potential infringement on the intellectual property rights of others, cyber security risks or potential breaches of data security;
and (10) other risks and uncertainties described in the registration statement on Form S-1 filed with the SEC on June 14,
2023, and such other documents filed by Zura Bio from time to time with the SEC. These risks and uncertainties may be amplified by
the COVID-19 pandemic or other unanticipated global disruption events, which may continue to cause economic uncertainty. Zura Bio cautions
that the foregoing list of factors is not exclusive or exhaustive and not to place undue reliance upon any forward-looking statements,
including projections, which speak only as of the date made. Zura Bio gives no assurance that it will achieve its expectations. Zura Bio
does not undertake or accept any obligation to publicly provide revisions or updates to any forward-looking statements, whether as a result
of new information, future developments or otherwise, or should circumstances change, except as otherwise required by securities and other
applicable laws.
Contact
- Zura Bio Investors:
Zura Bio Limited
Megan K. Weinshank,
Head of Investor Relations
info@zurabio.com
Meru Advisors
Lee M. Stern
lstern@meruadvisors.com
Zura Bio Limited
Condensed Consolidated Balance Sheets
(In thousands, except share data)
| |
June 30, 2023 | | |
December 31, 2022 | |
| |
| (unaudited) | | |
| | |
Assets | |
| | | |
| | |
Current assets: | |
| | | |
| | |
Cash and cash equivalents | |
$ | 112,802 | | |
$ | 1,567 | |
Prepaid expenses and other current assets | |
| 530 | | |
| 209 | |
Total current assets | |
| 113,332 | | |
| 1,776 | |
Deferred offering costs | |
| — | | |
| 3,486 | |
Total assets | |
$ | 113,332 | | |
$ | 5,262 | |
| |
| | | |
| | |
Liabilities, Convertible Preferred Shares, Redeemable Noncontrolling Interest and Shareholders’ Equity (Deficit) | |
| | | |
| | |
Current liabilities: | |
| | | |
| | |
Accounts payable and accrued expenses | |
$ | 19,940 | | |
$ | 4,428 | |
Note payable | |
| — | | |
| 7,756 | |
Research and development license consideration liability | |
| — | | |
| 2,634 | |
Total current liabilities | |
| 19,940 | | |
| 14,818 | |
Private placement warrants | |
| 2,069 | | |
| — | |
Total liabilities | |
| 22,009 | | |
| 14,818 | |
| |
| | | |
| | |
Commitments and contingencies | |
| | | |
| | |
| |
| | | |
| | |
Convertible preferred shares | |
| | | |
| | |
Series A-1 convertible preferred shares, $0.001 par value, -0- and 13,510,415 shares authorized, issued and outstanding as of June 30, 2023 and December 31, 2022 | |
| — | | |
| 12,500 | |
| |
| | | |
| | |
Redeemable noncontrolling interest | |
| 20,875 | | |
| 10,000 | |
| |
| | | |
| | |
Shareholders’ Equity (Deficit): | |
| | | |
| | |
Preferred shares, $0.0001 par value, 1,000,000 and -0- authorized as of June 30, 2023 and December 31, 2022, respectively; -0- issued and outstanding as of June 30, 2023 and December 31, 2022 | |
| — | | |
| — | |
Class A Ordinary shares, $0.0001 par value, 300,000,000 authorized, 43,093,685 issued and outstanding as of June 30, 2023; 1,884,649 authorized, 383,479 issued and outstanding as of December 31, 2022 | |
| 4 | | |
| — | |
Additional paid-in capital | |
| 155,654 | | |
| — | |
Accumulated deficit | |
| (86,751 | ) | |
| (32,056 | ) |
Total Zura Bio Limited shareholders’ equity (deficit) | |
| 68,907 | | |
| (32,056 | ) |
Noncontrolling interest | |
| 1,541 | | |
| — | |
Total shareholders’ equity (deficit) | |
| 70,448 | | |
| (32,056 | ) |
Total liabilities, convertible preferred shares, redeemable noncontrolling interest and shareholders’ equity (deficit) | |
$ | 113,332 | | |
$ | 5,262 | |
Zura Bio Limited
Condensed Consolidated Statements of Operations
(Unaudited)
(In thousands, except share and per share data)
| |
For the Three Months Ended June 30, | | |
For the Six Months Ended June 30, 2023 | |
| |
2023 | | |
2022 | | |
| |
Operating expenses: | |
| | | |
| | | |
| | |
Research and development | |
$ | 28,230 | | |
$ | 85 | | |
$ | 33,114 | |
General and administrative | |
| 5,675 | | |
| 842 | | |
| 8,510 | |
Total operating expenses | |
| 33,905 | | |
| 927 | | |
| 41,624 | |
Loss from operations | |
| (33,905 | ) | |
| (927 | ) | |
| (41,624 | ) |
Other expense/(income), net: | |
| | | |
| | | |
| | |
Other income, net | |
| (412 | ) | |
| (2 | ) | |
| (403 | ) |
Change in fair value of private placement warrants | |
| 532 | | |
| — | | |
| 355 | |
Change in fair value of note payable | |
| — | | |
| — | | |
| 2,244 | |
Total other expense/(income), net | |
| 120 | | |
| (2 | ) | |
| 2,196 | |
Loss before income taxes | |
| (34,025 | ) | |
| (925 | ) | |
| (43,820 | ) |
Income tax benefit | |
| — | | |
| — | | |
| — | |
Net loss before redeemable noncontrolling interest | |
| (34,025 | ) | |
| (925 | ) | |
| (43,820 | ) |
Net loss attributable to redeemable noncontrolling interest | |
| — | | |
| — | | |
| 203 | |
Net loss | |
| (34,025 | ) | |
| (925 | ) | |
| (43,617 | ) |
Adjustment to Zura subsidiary’s preferred stock to redemption | |
| — | | |
| — | | |
| (203 | ) |
Deemed dividend to redeemable noncontrolling interest | |
| (10,875 | ) | |
| — | | |
| (10,875 | ) |
Net loss attributable to Class A Ordinary Shareholders of Zura | |
$ | (44,900 | ) | |
$ | (925 | ) | |
$ | (54,695 | ) |
Net loss per share attributable to Class A Ordinary Shareholders of Zura, basic and diluted | |
$ | (1.31 | ) | |
$ | (9.54 | ) | |
$ | (2.88 | ) |
Weighted-average Class A Ordinary Shares used in computing net loss per share attributable to Class A Ordinary Shareholders of Zura, basic and diluted | |
| 34,303,125 | | |
| 97,004 | | |
| 19,012,464 | |
v3.23.2
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