| TPG GP A, LLC | Institution | 6.877.580 | 6,70% | US$ 39,20M | 2026-04-17 |
| Franklin Resources, Inc. | Institution | 6.369.252 | 6,20% | US$ 36,30M | 2026-04-30 |
| venBio LLC | Institution | 5.914.720 | 5,76% | US$ 33,71M | 2026-04-17 |
| Venbio Global Strategic Fund V, L.P. | Institution | 5.914.720 | 5,76% | US$ 33,71M | 2026-04-17 |
| Paradigm Biocapital Advisors LP | Institution | 4.951.856 | 4,82% | US$ 28,23M | 2026-04-17 |
| Paradigm BioCapital International Fund Ltd. | Institution | 4.343.768 | 4,23% | US$ 24,76M | 2026-04-17 |
| Dialectic Capital Management, LP | Institution | 3.494.000 | 3,40% | US$ 19,92M | 2025-04-15 |
| VR Management, LLC | Institution | 2.751.032 | 2,68% | US$ 15,68M | 2026-04-17 |
| Propel Bio Management, LLC | Institution | 2.601.913 | 2,53% | US$ 14,83M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.204.714 | 2,15% | US$ 12,57M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 1.843.960 | 1,80% | US$ 10,51M | 2026-04-17 |
| Contrarian Alpha Management, LLC | Institution | 1.668.918 | 1,63% | US$ 9,51M | 2025-11-14 |
| Patrick Callahan | Insider | 1.528.293 | 1,49% | US$ 8,71M | 2025-04-15 |
| Simplify Asset Management Inc. | Institution | 1.184.512 | 1,15% | US$ 6,75M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.077.338 | 1,05% | US$ 6,14M | 2026-03-31 |
| Marshall Wace LLP | Institution | 1.019.281 | 0,99% | US$ 5,81M | 2026-03-31 |
| LPL Financial LLC | Institution | 728.448 | 0,71% | US$ 4,15M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 722.696 | 0,70% | US$ 4,12M | 2026-04-17 |
| Nantahala Capital Management, LLC | Institution | 648.885 | 0,63% | US$ 3,70M | 2026-03-31 |
| Raymond James Financial, Inc. | Institution | 641.925 | 0,63% | US$ 3,66M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 622.785 | 0,61% | US$ 3,55M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 588.551 | 0,57% | US$ 3,35M | 2026-03-31 |
| Kvp Capital Advisors, LP | Institution | 462.355 | 0,45% | US$ 2,64M | 2026-03-31 |
| BlackRock, Inc. | Institution | 439.360 | 0,43% | US$ 2,50M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 383.683 | 0,37% | US$ 2,19M | 2026-03-31 |
| UBS Asset Management AG | Institution | 326.270 | 0,32% | US$ 1,86M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 316.177 | 0,31% | US$ 1,80M | 2026-03-31 |
| Mr. Thomas King | Insider | 315.142 | 0,31% | US$ 1,80M | 2025-09-04 |
| State Street Global Advisors, Inc. | Institution | 254.457 | 0,25% | US$ 1,45M | 2026-03-31 |
| Dr. Richard A. Stewart | Insider | 229.234 | 0,22% | US$ 1,31M | 2026-05-15 |
| Northern Trust Global Investments | Institution | 224.742 | 0,22% | US$ 1,28M | 2026-03-31 |
| Shay Capital LLC | Institution | 205.114 | 0,20% | US$ 1,17M | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 200.000 | 0,19% | US$ 1,14M | 2026-03-31 |
| VHCP Co-Investment Holdings III, LLC | Institution | 184.376 | 0,18% | US$ 1,05M | 2026-04-17 |
| Jane Street Group, LLC | Institution | 176.600 | 0,17% | US$ 1,01M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 152.952 | 0,15% | US$ 871,83k | 2026-03-31 |
| Mr. Mark Oki | Insider | 127.940 | 0,12% | US$ 729,26k | 2025-09-18 |
| Dr. Cindy Jacobs | Insider | 115.585 | 0,11% | US$ 658,83k | 2025-09-04 |
| Lakeside Advisors, Inc. | Institution | 111.101 | 0,11% | US$ 633,28k | 2026-03-31 |
| Wells Fargo & Company | Institution | 101.971 | 0,10% | US$ 581,23k | 2026-03-31 |
| Mr. John Bencich | Insider | 100.636 | 0,10% | US$ 573,63k | 2025-04-15 |