| BlackRock, Inc. | Institution | 22.650.988 | 8,91% | US$ 224,24M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 15.827.186 | 6,23% | US$ 156,69M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 15.302.186 | 6,02% | US$ 151,49M | 2025-11-04 |
| Deerfield Management Company, L.P. | Institution | 15.038.000 | 5,92% | US$ 148,88M | 2026-03-31 |
| Deerfield Partners, LP | Institution | 14.341.000 | 5,64% | US$ 141,98M | 2025-12-31 |
| State Street Global Advisors, Inc. | Institution | 12.208.360 | 4,80% | US$ 120,86M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 11.244.625 | 4,42% | US$ 111,32M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 11.135.762 | 4,38% | US$ 110,24M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 11.020.968 | 4,34% | US$ 109,11M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 8.908.506 | 3,51% | US$ 88,19M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 7.434.033 | 2,92% | US$ 73,60M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 7.025.000 | 2,76% | US$ 69,55M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 6.392.628 | 2,52% | US$ 63,29M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 5.782.776 | 2,28% | US$ 57,25M | 2026-03-31 |
| Kynam Capital Management, LP | Institution | 5.680.795 | 2,24% | US$ 56,24M | 2026-03-31 |
| UBS Asset Management AG | Institution | 5.312.972 | 2,09% | US$ 52,60M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 5.040.670 | 1,98% | US$ 49,90M | 2026-03-31 |
| Bank of America Corporation | Institution | 4.778.367 | 1,88% | US$ 47,31M | 2026-03-31 |
| Frazier Life Sciences Management, LP | Institution | 4.009.240 | 1,58% | US$ 39,69M | 2026-03-31 |
| RP Management, LLC | Institution | 3.846.154 | 1,51% | US$ 38,08M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 3.595.530 | 1,41% | US$ 35,60M | 2026-03-31 |
| GW&K Investment Management, LLC | Institution | 3.240.462 | 1,27% | US$ 32,08M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 3.189.320 | 1,25% | US$ 31,57M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 3.039.820 | 1,20% | US$ 30,09M | 2026-03-31 |
| RFG Advisory, LLC | Institution | 2.870.700 | 1,13% | US$ 28,42M | 2026-03-31 |
| Fisher Asset Management, LLC | Institution | 2.733.253 | 1,08% | US$ 27,06M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 2.690.651 | 1,06% | US$ 26,64M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 2.350.405 | 0,92% | US$ 23,27M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 2.286.841 | 0,90% | US$ 22,64M | 2026-03-31 |
| Rice Hall James & Associates, LLC | Institution | 2.230.105 | 0,88% | US$ 22,08M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 2.104.725 | 0,83% | US$ 20,84M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 1.987.397 | 0,78% | US$ 19,68M | 2026-03-31 |
| Stifel Asset Management Corp. | Institution | 1.825.184 | 0,72% | US$ 18,07M | 2026-03-31 |
| Parkman Healthcare Partners LLC | Institution | 1.708.099 | 0,67% | US$ 16,91M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 1.664.297 | 0,65% | US$ 16,48M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.641.076 | 0,65% | US$ 16,25M | 2026-03-31 |
| Morgan Stanley | Institution | 1.580.052 | 0,62% | US$ 15,64M | 2026-03-31 |
| Pacer Advisors, Inc. | Institution | 1.563.040 | 0,61% | US$ 15,47M | 2026-03-31 |