RNS Number : 9983I
  State Street Global Advisors
  26 November 2008
   


                                                                    FORM 8.3
    DEALINGS BY PERSONS WITH INTERESTS IN SECURITIES REPRESENTING 1% OR MORE 
    (Rule 8.3 of the City Code on Takeovers & Mergers)

    1. KEY INFORMATION

    Name of Person              State Street
    Dealing (Note 1)            Global Advisors & Affiliates
    Company Dealt In            Protherics PLC
    Class of Relevant Security  Ord                       
    to Which the Dealings                              
    Being Disclosed                                    
    Relate (Note 2)                                    
    Date of Dealing             25/11/2008                
                                                          

    2. INTERESTS, SHORT POSITIONS & RIGHTS TO SUBSCRIBE



    (a) Interests & Short Positions (following dealing) in 
       the Class of Relevant Security Dealt In (Note 3)

    Class of Relevant Security: Long                      Short                     
                                Number       %            Number       %            
    (1) Relevant Securities     3613763      1.05616                                
    (2) Derivatives             0            0.00000      0            0.00000      
        other than options                                                          
    (3) Options &                                                                   
        Agreements to                                                               
        Purchase/Sell                                                               
    Total                       3613763      1.05616      0            0.00000      
                                                                                    

    (b) Interests & Short Positions in Relevant Securities of the Company 
       (ex.Class Dealt In) (Note 3)


    Class of Relevant Security: Long                      Short                     
                                Number       %            Number       %            
    (1) Relevant Securities                                                         
    (2) Derivatives                                                                 
        other than options                                                          
    (3) Options &                                                                   
        Agreements to                                                               
        Purchase/Sell                                                               
    Total                                                                           
                                                                                    

    (c) Rights to Subscribe (Note 3)

    Class of Relevant Security: Details                   
                                                          
                                                          
                                                          

    3. DEALINGS (Note 4)

    (a) Purchases & Sales

    Purchase /                  Number of    Price                     
    Sale                        Securities   per Unit                  
                                                                       
    SELL                        3458         0.43                      
                                                                       

    (b) Derivatives Transactions (other than options)

    Product Name (e.g. CFD)     Long/Short   No./Securites   Price/Unit             
                                (Note 6)     (Note 7)        (Note 5)               
                                                                                    
    CFD                                      3458            0.43                   
                                                                                    

    (c) Options Transactions in Respect of Existing Securities
       (i) Writing, Selling, Purchasing or Varying

    Product Name                Write,Sell   No/Securities   Exercise  Type         
    (eg call option)            Purchasing,  Which the       Price     (e.g. USA,   
                                Varying etc. Optn Relates              European etc)
                                             Relates-Note7                          
                                                                                    
                                                                                    

    Expiry Date                 Option Money              
                                Paid/Received             
                                per Unit                  
                                (Note 5)                  
                                                          
                                                          

        (ii) Exercising

    Product Name                Number of    Exercise                  
    (eg call option)            Securities   Price per                 
                                             Unit (Note 5)             
                                                                       
                                                                       

    (d) Other Dealings (including new securities) (Note 4)

    Nature of Transaction       Details      Price / Unit              
    (Note 8)                                 if applicable             
                                             (Note 5)                  
                                                                       
                                                                       

    4. OTHER INFORMATION

    (a)Agreements, Arrangements or Understandings Relating to Options or Derivatives
    Full details of any agreement, arrangement or understanding between the person
    disclosing & any other person relating to the voting rights of any relevant
    securities under any option referred to on this form or relating to the voting
    rights or future acquisition or disposal of any relevant securities to which
    any derivative referred to on this form is referenced.
    If none, this should be stated.



    Is a Supplemental Form 8 Attached? (Note 9)     NO

    Disclosure Date             26/11/2008
    Contact Name                Harshil Naik
    Telephone Number            020 7698 6213             
    If Connected EFM            N/A                       
    Name of Offeree/Offeror                            
    With Which Connected                               
    If Connected EFM            N/A                       
    State Nature of                                    
    Connection (Note 10)                               
                                                          

    Notes:
    The Notes on Form 8.3 can be viewed on the
    Takeover Panel's website at www.thetakeoverpanel.org.uk

This information is provided by RNS
The company news service from the London Stock Exchange
 
  END 
 
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