| FMR LLC | Institution | 15.379.377 | 13,93% | US$ 254,84M | 2026-03-31 |
| BlackRock, Inc. | Institution | 7.831.475 | 7,09% | US$ 129,77M | 2026-03-31 |
| Bellevue Asset Management AG | Institution | 6.726.144 | 6,09% | US$ 111,45M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 5.417.660 | 4,91% | US$ 89,77M | 2026-05-01 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 5.417.660 | 4,91% | US$ 89,77M | 2026-05-01 |
| Fairmount Funds Management LLC | Institution | 5.090.928 | 4,61% | US$ 84,36M | 2026-05-11 |
| Fairmount Healthcare Fund II L.P. | Institution | 5.090.928 | 4,61% | US$ 84,36M | 2026-05-11 |
| State Street Global Advisors, Inc. | Institution | 4.672.885 | 4,23% | US$ 77,43M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 4.300.000 | 3,89% | US$ 71,25M | 2025-04-04 |
| Vanguard Capital Management, LLC | Institution | 4.167.201 | 3,77% | US$ 69,05M | 2026-03-31 |
| VR Management, LLC | Institution | 3.882.709 | 3,52% | US$ 64,34M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 3.206.035 | 2,90% | US$ 53,12M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 3.148.893 | 2,85% | US$ 52,18M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 3.078.554 | 2,79% | US$ 51,01M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 2.812.665 | 2,55% | US$ 46,61M | 2024-09-30 |
| Paradigm BioCapital International Fund Ltd. | Institution | 2.490.901 | 2,26% | US$ 41,27M | 2024-09-30 |
| Kynam Capital Management, LP | Institution | 2.341.652 | 2,12% | US$ 38,80M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2.333.213 | 2,11% | US$ 38,66M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 2.318.234 | 2,10% | US$ 38,41M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 2.315.957 | 2,10% | US$ 38,38M | 2026-03-31 |
| Novo Holdings A/S | Institution | 2.000.000 | 1,81% | US$ 33,14M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 1.971.678 | 1,79% | US$ 32,67M | 2026-03-31 |
| Tang Capital Management, LLC | Institution | 1.792.626 | 1,62% | US$ 29,70M | 2026-03-31 |
| Fisher Asset Management, LLC | Institution | 1.768.295 | 1,60% | US$ 29,30M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.641.477 | 1,49% | US$ 27,20M | 2026-03-31 |
| Avoro Capital Advisors LLC | Institution | 1.500.000 | 1,36% | US$ 24,86M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 1.392.072 | 1,26% | US$ 23,07M | 2026-03-31 |
| Venrock Opportunities Fund, L.P. | Institution | 1.352.322 | 1,22% | US$ 22,41M | 2024-09-30 |
| D. E. Shaw & Co., L.P. | Institution | 1.262.540 | 1,14% | US$ 20,92M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.195.432 | 1,08% | US$ 19,81M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 1.170.829 | 1,06% | US$ 19,40M | 2026-03-31 |
| Bank of America Corporation | Institution | 1.134.710 | 1,03% | US$ 18,80M | 2026-03-31 |
| Deutsche Asset & Wealth Management | Institution | 1.032.316 | 0,93% | US$ 17,11M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.027.303 | 0,93% | US$ 17,02M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 1.011.456 | 0,92% | US$ 16,76M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 970.018 | 0,88% | US$ 16,07M | 2026-03-31 |
| Loomis Sayles & Company, L.P. | Institution | 927.717 | 0,84% | US$ 15,37M | 2026-03-31 |
| First Turn Management, LLC | Institution | 911.337 | 0,83% | US$ 15,10M | 2026-03-31 |