| Janus Henderson Group plc | Institution | 5.207.011 | 9,26% | US$ 19,89M | 2026-03-31 |
| BlackRock, Inc. | Institution | 3.394.968 | 6,04% | US$ 12,97M | 2026-03-31 |
| Janus Henderson Biotech Innovation Master Fund Limited | Institution | 3.356.076 | 5,97% | US$ 12,82M | 2025-03-31 |
| Velan Capital Partners LP | Institution | 2.834.652 | 5,04% | US$ 10,83M | 2026-03-31 |
| Millennium Management LLC | Institution | 2.831.208 | 5,04% | US$ 10,82M | 2026-03-31 |
| Blackstone Alternative Asset Management L.P. | Institution | 2.265.514 | 4,03% | US$ 8,65M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.119.018 | 3,77% | US$ 8,09M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 1.969.839 | 3,50% | US$ 7,52M | 2026-03-31 |
| Acorn Bioventures | Institution | 1.752.115 | 3,12% | US$ 6,69M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 1.750.000 | 3,11% | US$ 6,69M | 2026-03-31 |
| Aigh Capital Management, LLC | Institution | 1.622.733 | 2,89% | US$ 6,20M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.402.864 | 2,50% | US$ 5,36M | 2026-03-31 |
| 5AM Venture Management, LLC | Institution | 1.369.782 | 2,44% | US$ 5,23M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.177.200 | 2,09% | US$ 4,50M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 1.152.714 | 2,05% | US$ 4,40M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.068.558 | 1,90% | US$ 4,08M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 1.039.295 | 1,85% | US$ 3,97M | 2025-06-30 |
| Patient Square Capital, LP | Institution | 1.030.846 | 1,83% | US$ 3,94M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.005.142 | 1,79% | US$ 3,84M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 971.614 | 1,73% | US$ 3,71M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 940.512 | 1,67% | US$ 3,59M | 2026-03-31 |
| Bank of America Corporation | Institution | 925.918 | 1,65% | US$ 3,54M | 2026-03-31 |
| J. Goldman & Co., L.P. | Institution | 856.247 | 1,52% | US$ 3,27M | 2026-03-31 |
| Heights Capital Management, Inc. | Institution | 600.380 | 1,07% | US$ 2,29M | 2024-09-30 |
| Catalio Capital Management, LP | Institution | 580.024 | 1,03% | US$ 2,22M | 2026-03-31 |
| Assenagon Asset Management S.A. | Institution | 567.621 | 1,01% | US$ 2,17M | 2026-03-31 |
| Morgan Stanley | Institution | 544.302 | 0,97% | US$ 2,08M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 531.267 | 0,95% | US$ 2,03M | 2026-03-31 |
| Burkehill Global Management, LP | Institution | 450.000 | 0,80% | US$ 1,72M | 2026-03-31 |
| Walleye Capital LLC | Institution | 443.401 | 0,79% | US$ 1,69M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 412.604 | 0,73% | US$ 1,58M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 377.793 | 0,67% | US$ 1,44M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 374.852 | 0,67% | US$ 1,43M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 350.000 | 0,62% | US$ 1,34M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 308.842 | 0,55% | US$ 1,18M | 2026-03-31 |
| Oppenheimer Asset Management Inc. | Institution | 181.565 | 0,32% | US$ 693,58k | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 177.004 | 0,31% | US$ 676,16k | 2026-03-31 |
| Canadian Imperial Bank of Commerce | Institution | 175.495 | 0,31% | US$ 670,39k | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 153.985 | 0,27% | US$ 588,22k | 2025-12-31 |
| Charles Schwab Investment Management, Inc. | Institution | 147.888 | 0,26% | US$ 564,93k | 2026-03-31 |