| BVF Partners L.P. | Institution | 16.001.284 | 21,74% | US$ 311,54M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 8.302.735 | 11,28% | US$ 161,65M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 6.599.722 | 8,97% | US$ 128,50M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 6.408.863 | 8,71% | US$ 124,78M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 4.610.071 | 6,26% | US$ 89,76M | 2025-11-12 |
| Cormorant Asset Management, LP | Institution | 4.480.433 | 6,09% | US$ 87,23M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 3.451.628 | 4,69% | US$ 67,20M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 2.390.661 | 3,25% | US$ 46,55M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 1.811.082 | 2,46% | US$ 35,26M | 2026-03-31 |
| Weiss Asset Management, LLC | Institution | 1.708.328 | 2,32% | US$ 33,26M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 1.500.000 | 2,04% | US$ 29,21M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 1.368.518 | 1,86% | US$ 26,65M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1.065.610 | 1,45% | US$ 20,75M | 2026-03-31 |
| Biotechnology Value Trading Fund OS LP | Institution | 1.039.238 | 1,41% | US$ 20,23M | 2026-03-31 |
| Vivo Capital, LLC | Institution | 1.000.000 | 1,36% | US$ 19,47M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 818.126 | 1,11% | US$ 15,93M | 2026-03-31 |
| Medical Strategy GmbH | Institution | 717.589 | 0,97% | US$ 13,97M | 2025-09-30 |
| Cormorant Global Healthcare Master Fund, LP | Institution | 638.740 | 0,87% | US$ 12,44M | 2025-09-30 |
| Holocene Advisors, LP | Institution | 600.000 | 0,82% | US$ 11,68M | 2026-03-31 |
| Jefferies Financial Group Inc. | Institution | 500.000 | 0,68% | US$ 9,74M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 500.000 | 0,68% | US$ 9,74M | 2026-03-31 |
| Trexquant Investment LP | Institution | 495.336 | 0,67% | US$ 9,64M | 2026-03-31 |
| Hudson River Trading LLC | Institution | 487.583 | 0,66% | US$ 9,49M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 457.137 | 0,62% | US$ 8,90M | 2026-03-31 |
| Casdin Capital, LLC | Institution | 450.000 | 0,61% | US$ 8,76M | 2026-03-31 |
| Longaeva Partners L.P. | Institution | 410.000 | 0,56% | US$ 7,98M | 2026-03-31 |
| J.P. Morgan Mansart Management Limited | Institution | 390.700 | 0,53% | US$ 7,61M | 2026-03-31 |
| Voleon Capital Management LP | Institution | 373.021 | 0,51% | US$ 7,26M | 2026-03-31 |
| Leap Investments LP | Institution | 324.900 | 0,44% | US$ 6,33M | 2026-03-31 |
| First Turn Management, LLC | Institution | 315.563 | 0,43% | US$ 6,14M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 275.000 | 0,37% | US$ 5,35M | 2026-03-31 |
| Rhenman & Partners Asset Management AB | Institution | 239.500 | 0,33% | US$ 4,66M | 2026-03-31 |
| Granahan Investment Management, LLC | Institution | 220.600 | 0,30% | US$ 4,30M | 2026-03-31 |
| Exome Asset Management LLC | Institution | 215.376 | 0,29% | US$ 4,19M | 2026-03-31 |
| HighVista Strategies LLC | Institution | 193.955 | 0,26% | US$ 3,78M | 2026-03-31 |
| Acuta Capital Partners, LLC | Institution | 191.760 | 0,26% | US$ 3,73M | 2026-03-31 |
| Congress Asset Management Company, LLP | Institution | 178.555 | 0,24% | US$ 3,48M | 2026-03-31 |
| Kalehua Capital Management LLC | Institution | 175.734 | 0,24% | US$ 3,42M | 2026-03-31 |
| Ishara Investments, L.P. | Institution | 174.250 | 0,24% | US$ 3,39M | 2026-03-31 |
| Rice Hall James & Associates, LLC | Institution | 167.766 | 0,23% | US$ 3,27M | 2026-03-31 |
| Algert Global LLC | Institution | 151.256 | 0,21% | US$ 2,94M | 2026-03-31 |
| Readystate Asset Management LP | Institution | 144.238 | 0,20% | US$ 2,81M | 2026-03-31 |
| J. Goldman & Co., L.P. | Institution | 136.900 | 0,19% | US$ 2,67M | 2026-03-31 |
| Y-Intercept (Hong Kong) Limited | Institution | 127.087 | 0,17% | US$ 2,47M | 2026-03-31 |