| BVF Partners L.P. | Institution | 16.001.284 | 21,74% | US$ 286,42M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 8.302.735 | 11,28% | US$ 148,62M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 6.599.722 | 8,97% | US$ 118,14M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 6.408.863 | 8,71% | US$ 114,72M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 4.610.071 | 6,26% | US$ 82,52M | 2025-11-12 |
| Cormorant Asset Management, LP | Institution | 4.480.433 | 6,09% | US$ 80,20M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 3.451.628 | 4,69% | US$ 61,78M | 2026-03-31 |
| Dr. Kristian Reich | Insider | 3.010.992 | 4,09% | US$ 53,90M | 2026-04-01 |
| Dr. Jorge da Silva | Insider | 2.924.893 | 3,97% | US$ 52,36M | 2026-04-13 |
| D. E. Shaw & Co., L.P. | Institution | 2.390.661 | 3,25% | US$ 42,79M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 1.811.082 | 2,46% | US$ 32,42M | 2026-03-31 |
| Weiss Asset Management, LLC | Institution | 1.708.328 | 2,32% | US$ 30,58M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 1.500.000 | 2,04% | US$ 26,85M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 1.368.518 | 1,86% | US$ 24,50M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.323.728 | 1,80% | US$ 23,69M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 1.294.861 | 1,76% | US$ 23,18M | 2026-03-31 |
| Mr. Matthias Bodenstedt | Insider | 1.172.431 | 1,59% | US$ 20,99M | 2026-05-11 |
| The Goldman Sachs Group, Inc. | Institution | 1.130.233 | 1,54% | US$ 20,23M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.122.312 | 1,52% | US$ 20,09M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1.065.610 | 1,45% | US$ 19,07M | 2026-03-31 |
| Biotechnology Value Trading Fund OS LP | Institution | 1.039.238 | 1,41% | US$ 18,60M | 2026-03-31 |
| BlackRock, Inc. | Institution | 1.021.851 | 1,39% | US$ 18,29M | 2026-03-31 |
| Vivo Capital, LLC | Institution | 1.000.000 | 1,36% | US$ 17,90M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 818.126 | 1,11% | US$ 14,64M | 2026-03-31 |
| Medical Strategy GmbH | Institution | 717.589 | 0,97% | US$ 12,84M | 2025-09-30 |
| JPMorgan Chase & Co. | Institution | 697.814 | 0,95% | US$ 12,49M | 2026-03-31 |
| Bank of America Corporation | Institution | 691.888 | 0,94% | US$ 12,38M | 2026-03-31 |
| Cormorant Global Healthcare Master Fund, LP | Institution | 638.740 | 0,87% | US$ 11,43M | 2025-09-30 |
| Morgan Stanley | Institution | 609.084 | 0,83% | US$ 10,90M | 2026-03-31 |
| Holocene Advisors, LP | Institution | 600.000 | 0,82% | US$ 10,74M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 595.398 | 0,81% | US$ 10,66M | 2026-03-31 |
| Cormorant Private Healthcare Fund III LP | Institution | 577.783 | 0,78% | US$ 10,34M | 2025-09-30 |
| Millennium Management LLC | Institution | 576.092 | 0,78% | US$ 10,31M | 2026-03-31 |
| Jefferies Financial Group Inc. | Institution | 500.000 | 0,68% | US$ 8,95M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 500.000 | 0,68% | US$ 8,95M | 2026-03-31 |
| Trexquant Investment LP | Institution | 495.336 | 0,67% | US$ 8,87M | 2026-03-31 |
| Hudson River Trading LLC | Institution | 487.583 | 0,66% | US$ 8,73M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 457.137 | 0,62% | US$ 8,18M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 453.625 | 0,62% | US$ 8,12M | 2026-03-31 |
| Casdin Capital, LLC | Institution | 450.000 | 0,61% | US$ 8,06M | 2026-03-31 |
| Cormorant Private Healthcare Fund II, LP | Institution | 424.466 | 0,58% | US$ 7,60M | 2025-09-30 |
| Longaeva Partners L.P. | Institution | 410.000 | 0,56% | US$ 7,34M | 2026-03-31 |
| J.P. Morgan Mansart Management Limited | Institution | 390.700 | 0,53% | US$ 6,99M | 2026-03-31 |
| Voleon Capital Management LP | Institution | 373.021 | 0,51% | US$ 6,68M | 2026-03-31 |
| Cormorant Private Healthcare Fund IV LP | Institution | 353.184 | 0,48% | US$ 6,32M | 2025-09-30 |
| Leap Investments LP | Institution | 324.900 | 0,44% | US$ 5,82M | 2026-03-31 |
| Walleye Capital LLC | Institution | 320.472 | 0,44% | US$ 5,74M | 2026-03-31 |
| First Turn Management, LLC | Institution | 315.563 | 0,43% | US$ 5,65M | 2026-03-31 |