| Farallon Capital Management, L.L.C. | Institution | 8.656.038 | 9,73% | US$ 665,82M | 2026-03-31 |
| Caligan Partners, LP | Institution | 8.138.951 | 9,15% | US$ 626,05M | 2026-05-19 |
| BlackRock, Inc. | Institution | 5.489.119 | 6,17% | US$ 422,22M | 2026-03-31 |
| Farallon Healthcare Partners Master, L.P. | Institution | 4.934.276 | 5,55% | US$ 379,54M | 2025-12-31 |
| Mr. Paul Manning | Insider | 4.579.729 | 5,15% | US$ 352,27M | 2026-06-04 |
| Findell Capital Management LLC | Institution | 3.502.112 | 3,94% | US$ 269,38M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.926.945 | 3,29% | US$ 225,14M | 2026-03-31 |
| Opaleye Management Inc. | Institution | 2.545.000 | 2,86% | US$ 195,76M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.928.969 | 2,17% | US$ 148,38M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.881.599 | 2,12% | US$ 144,73M | 2026-03-31 |
| Legend Aggregator Advisors, LLC | Institution | 1.860.371 | 2,09% | US$ 143,10M | 2024-12-31 |
| Dr. Roger Jeffs | Insider | 1.801.648 | 2,03% | US$ 138,58M | 2026-05-27 |
| Farallon Capital Offshore Investors II, L.P | Institution | 1.530.567 | 1,72% | US$ 117,73M | 2025-12-31 |
| MPM BioImpact LLC | Institution | 1.405.158 | 1,58% | US$ 108,08M | 2026-03-31 |
| The Caprock Group, LLC | Institution | 1.367.235 | 1,54% | US$ 105,17M | 2026-03-31 |
| Canaan VIII, L.P. | Institution | 1.176.184 | 1,32% | US$ 90,47M | 2026-06-11 |
| Canaan Management, Inc. | Institution | 1.176.184 | 1,32% | US$ 90,47M | 2026-06-11 |
| Susquehanna International Group, LLP | Institution | 1.001.081 | 1,13% | US$ 77,00M | 2026-03-31 |
| Merrill Lynch, Pierce, Fenner & Smith Incorporated | Institution | 995.413 | 1,12% | US$ 76,57M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 953.151 | 1,07% | US$ 73,32M | 2026-03-31 |
| Bank of America Corporation | Institution | 903.482 | 1,02% | US$ 69,50M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 873.065 | 0,98% | US$ 67,16M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 795.884 | 0,89% | US$ 61,22M | 2026-03-31 |
| Tiger Lily Capital | Institution | 716.311 | 0,81% | US$ 55,10M | 2026-06-04 |
| Farallon Capital Partners, L.P. | Institution | 691.175 | 0,78% | US$ 53,17M | 2025-12-31 |
| Eversept Partners, L.P. | Institution | 677.392 | 0,76% | US$ 52,10M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 652.406 | 0,73% | US$ 50,18M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 632.625 | 0,71% | US$ 48,66M | 2026-03-31 |
| Farallon Capital Institutional Partners, L.P. | Institution | 631.454 | 0,71% | US$ 48,57M | 2025-12-31 |
| Boothbay Fund Management, LLC | Institution | 625.048 | 0,70% | US$ 48,08M | 2026-03-31 |
| Buckley Capital Advisors, LLC | Institution | 624.844 | 0,70% | US$ 48,06M | 2026-03-31 |
| FMR LLC | Institution | 582.003 | 0,65% | US$ 44,77M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 579.875 | 0,65% | US$ 44,60M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 563.233 | 0,63% | US$ 43,32M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 557.200 | 0,63% | US$ 42,86M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 472.273 | 0,53% | US$ 36,33M | 2026-03-31 |
| Mr. Russell Schundler | Insider | 453.864 | 0,51% | US$ 34,91M | 2026-04-20 |
| Federated Hermes, Inc. | Institution | 438.767 | 0,49% | US$ 33,75M | 2026-03-31 |
| Invesco Capital Management LLC | Institution | 437.938 | 0,49% | US$ 33,69M | 2026-03-31 |
| PBM Capital Group LLC | Institution | 435.674 | 0,49% | US$ 33,51M | 2026-06-04 |
| Trexquant Investment LP | Institution | 409.259 | 0,46% | US$ 31,48M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 403.048 | 0,45% | US$ 31,00M | 2026-03-31 |
| Managed Account Advisors LLC | Institution | 388.897 | 0,44% | US$ 29,91M | 2026-03-31 |
| Pale Fire Capital SE | Institution | 388.377 | 0,44% | US$ 29,87M | 2026-03-31 |
| Oberweis Asset Management, Inc. | Institution | 372.100 | 0,42% | US$ 28,62M | 2026-03-31 |