| 2026-05-27 | Dr. Roger A. JeffsCEO & Director | -6,43k | 399,71k | Automatic Disposition | 62,18 | 1,80M | -0,36% |
| 2026-05-21 | Mr. Ramandeep SinghIndependent Director | -29,49k | 1,50M | Derivative Exercise and Sale | 8,63 - 60,13 | 20,36k | - |
| 2026-05-21 | Dr. Roger A. JeffsCEO & Director | -75,00k | 4,58M | Automatic Disposition | 60,38 - 61,52 | 1,81M | -3,98% |
| 2026-05-19 | Caligan Partners, LPUnternehmen | -5,30k | 317,89k | Verkauf | 59,98 | 8,14M | -0,07% |
| 2026-05-19 | Caligan Partners, LPUnternehmen | 5,30k | 317,89k | Kauf | 59,98 | 8,14M | 0,07% |
| 2026-05-18 | Dr. Roger A. JeffsCEO & Director | -75,00k | 4,42M | Automatic Disposition | 56,77 - 61,30 | 1,88M | -3,83% |
| 2026-05-13 | Dr. Roger A. JeffsCEO & Director | -75,00k | 4,30M | Automatic Disposition | 56,29 - 58,62 | 1,96M | -3,69% |
| 2026-05-11 | Canaan Management, Inc.Unternehmen | -318,89k | 16,02M | Verkauf | 48,61 - 53,25 | 1,87M | -14,57% |
| 2026-05-08 | Dr. Roger A. JeffsCEO & Director | -75,00k | 3,44M | Automatic Disposition | 41,50 - 54,04 | 2,03M | -3,56% |
| 2026-05-05 | Dr. Roger A. JeffsCEO & Director | -75,00k | 3,07M | Automatic Disposition | 40,10 - 42,09 | 2,11M | -3,44% |
| 2026-04-27 | Ms. Dana BoyleCAO | -1,58k | 59,54k | Verkauf | 37,78 | 57,30k | -2,68% |
| 2026-04-27 | Mr. Jason AdairChief Business Officer | -688,00 | 28,66k | Verkauf | 41,65 | 119,37k | -0,57% |
| 2026-04-17 | Dr. Roger A. JeffsCEO & Director | -18,84k | 764,96k | Automatic Disposition | 40,60 | 2,56M | -0,73% |
| 2026-04-14 | Dr. Roger A. JeffsCEO & Director | -53,30k | 2,14M | Automatic Disposition | 40,00 - 40,31 | 2,58M | -2,02% |
| 2026-04-14 | Mr. Michael KasetaCOO & CFO | -89,97k | 3,36M | Derivative Exercise and Sale | 2,79 - 40,14 | 353,36k | - |
| 2026-04-15 | Mr. Michael KasetaCOO & CFO | -52,42k | 2,10M | Automatic Disposition | 40,14 | 353,36k | -12,92% |
| 2026-04-10 | Mr. Jason AdairChief Business Officer | 2,95k | 0,00 | Derivative Exercise and Retained Stock | - | 118,50k | 2,55% |
| 2026-04-10 | Mr. Jason AdairChief Business Officer | -7,30k | 280,14k | Derivative Exercise and Sale | 38,37 | 118,50k | - |
| 2026-04-10 | Ms. Dana BoyleCAO | -3,18k | 121,98k | Derivative Exercise and Sale | 38,37 | 55,75k | - |
| 2026-04-13 | Ms. Dana BoyleCAO | -1,92k | 73,75k | Automatic Disposition | 38,37 | 55,75k | -3,33% |
| 2026-04-10 | Mr. Scott MoomawChief Commercial Officer | -7,47k | 286,43k | Derivative Exercise and Sale | 38,37 | 66,29k | - |
| 2026-04-13 | Mr. Scott MoomawChief Commercial Officer | -3,08k | 117,97k | Automatic Disposition | 38,20 - 38,37 | 66,29k | -4,44% |
| 2026-04-10 | Mr. Michael KasetaCOO & CFO | -36,70k | 1,38M | Derivative Exercise and Sale | 2,79 - 40,14 | 405,78k | - |
| 2026-04-13 | Mr. Michael KasetaCOO & CFO | -6,08k | 233,29k | Automatic Disposition | 38,37 | 405,78k | -1,48% |
| 2026-04-10 | Ms. Sarah KreppChief HR Officer | -3,18k | 121,98k | Derivative Exercise and Sale | 38,37 | 30,68k | - |
| 2026-04-13 | Ms. Sarah KreppChief HR Officer | -1,38k | 52,87k | Automatic Disposition | 38,37 | 30,68k | -4,30% |
| 2026-04-10 | Dr. Rajeev SaggarChief Medical Officer | -8,02k | 307,61k | Derivative Exercise and Sale | 38,37 | 50,63k | - |
| 2026-04-13 | Dr. Rajeev SaggarChief Medical Officer | -1,20k | 46,16k | Automatic Disposition | 38,37 | 50,63k | -2,32% |
| 2026-04-10 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | -10,17k | 390,11k | Derivative Exercise and Sale | 38,37 | 453,86k | - |
| 2026-04-13 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | -3,53k | 135,25k | Automatic Disposition | 38,37 | 453,86k | -0,77% |
| 2026-04-10 | Dr. Roger A. JeffsCEO & Director | -28,17k | 1,08M | Derivative Exercise and Sale | 38,37 | 2,63M | - |
| 2026-04-10 | Dr. Roger A. JeffsCEO & Director | -26,01k | 1,04M | Automatic Disposition | 38,37 - 40,12 | 2,63M | -0,98% |
| 2026-04-09 | Dr. Roger A. JeffsCEO & Director | -25,00k | 1,00M | Automatic Disposition | 40,12 | 2,24M | -1,11% |
| 2026-04-09 | Mr. Michael KasetaCOO & CFO | -133,79k | 5,01M | Derivative Exercise and Sale | 2,54 - 40,24 | 165,15k | - |
| 2026-03-26 | Canaan Management, Inc.Unternehmen | -70,23k | 2,53M | Verkauf | 35,42 - 37,22 | 2,19M | -3,11% |
| 2026-03-23 | Mr. Scott MoomawChief Commercial Officer | -17,00k | 568,02k | Derivative Exercise and Sale | 3,40 - 36,81 | 56,70k | - |
| 2026-03-23 | Mr. Scott MoomawChief Commercial Officer | -1,31k | 47,93k | Automatic Disposition | 36,48 | 56,70k | -2,27% |
| 2026-03-13 | Mr. Ramandeep SinghIndependent Director | -20,00k | 623,63k | Derivative Exercise and Sale | 4,86 - 36,04 | 20,36k | - |
| 2026-03-13 | Ms. Sarah KreppChief HR Officer | -16,26k | 617,92k | Verkauf | 38,00 | 24,88k | -39,53% |
| 2026-03-13 | Dr. Rajeev SaggarChief Medical Officer | -35,37k | 1,28M | Verkauf | 36,30 | 38,60k | -47,81% |
| 2026-03-09 | Mr. Scott MoomawChief Commercial Officer | -80,00k | 2,57M | Derivative Exercise and Sale | 2,54 - 35,32 | 58,01k | - |
| 2026-02-27 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | 1,27k | 0,00 | Derivative Exercise and Retained Stock | - | 437,59k | 0,29% |
| 2026-02-27 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | -1,07k | 32,81k | Derivative Exercise and Sale | 30,58 | 437,59k | - |
| 2026-02-27 | Mr. Scott MoomawChief Commercial Officer | 1,05k | 0,00 | Derivative Exercise and Retained Stock | - | 58,01k | 1,84% |
| 2026-02-27 | Mr. Scott MoomawChief Commercial Officer | -827,00 | 25,29k | Derivative Exercise and Sale | 30,58 | 58,01k | - |
| 2026-03-02 | Ms. Sarah KreppChief HR Officer | -276,00 | 8,44k | Automatic Disposition | 30,58 | 41,14k | -0,67% |
| 2026-02-27 | Mr. Michael KasetaCOO & CFO | 1,18k | 0,00 | Derivative Exercise and Retained Stock | - | 190,15k | 0,62% |
| 2026-02-27 | Mr. Michael KasetaCOO & CFO | -1,17k | 35,63k | Derivative Exercise and Sale | 30,58 | 190,15k | - |
| 2026-03-02 | Ms. Dana BoyleCAO | -445,00 | 13,61k | Automatic Disposition | 30,58 | 50,93k | -0,87% |
| 2026-02-27 | Mr. Jason AdairChief Business Officer | 873,00 | 0,00 | Derivative Exercise and Retained Stock | - | 109,21k | 0,81% |
| 2026-02-27 | Mr. Jason AdairChief Business Officer | -689,00 | 21,07k | Derivative Exercise and Sale | 30,58 | 109,21k | - |
| 2026-02-11 | Mr. Paul B. ManningIndependent Director | -55,12k | 2,35M | Other Disposition | 42,63 | 4,68M | -1,16% |
| 2026-01-26 | Ms. Dana BoyleCAO | -1,58k | 65,81k | Automatic Disposition | 41,65 | 49,99k | -3,06% |
| 2026-01-26 | Mr. Jason AdairChief Business Officer | -688,00 | 28,66k | Automatic Disposition | 41,65 | 107,90k | -0,63% |
| 2026-01-09 | Ms. Sarah KreppChief HR Officer | -12,72k | 475,96k | Derivative Exercise and Sale | 37,43 | 40,36k | - |
| 2026-01-12 | Ms. Sarah KreppChief HR Officer | -449,00 | 16,81k | Automatic Disposition | 37,43 | 40,36k | -1,10% |
| 2026-01-09 | Mr. Scott MoomawChief Commercial Officer | 8,00 | 0,00 | Derivative Exercise and Retained Stock | - | 56,52k | 0,01% |
| 2026-01-09 | Mr. Scott MoomawChief Commercial Officer | -20,53k | 768,55k | Derivative Exercise and Sale | 37,43 | 56,52k | - |
| 2026-01-09 | Mr. Michael KasetaCOO & CFO | -34,03k | 1,27M | Derivative Exercise and Sale | 37,43 | 163,53k | - |
| 2026-01-12 | Mr. Michael KasetaCOO & CFO | -2,90k | 108,70k | Automatic Disposition | 37,43 | 163,53k | -1,74% |
| 2026-01-09 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | 2,11k | 0,00 | Derivative Exercise and Retained Stock | - | 435,88k | 0,49% |
| 2026-01-09 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | -27,29k | 1,02M | Derivative Exercise and Sale | 37,43 | 435,88k | - |
| 2026-01-09 | Mr. Jason AdairChief Business Officer | 8,31k | 0,00 | Derivative Exercise and Retained Stock | - | 107,02k | 8,41% |
| 2026-01-09 | Mr. Jason AdairChief Business Officer | -13,55k | 507,10k | Derivative Exercise and Sale | 37,43 | 107,02k | - |
| 2026-01-09 | Dr. Roger A. JeffsCEO & Director | 4,56k | 0,00 | Derivative Exercise and Retained Stock | - | 2,27M | 0,20% |
| 2026-01-09 | Dr. Roger A. JeffsCEO & Director | -66,61k | 2,49M | Derivative Exercise and Sale | 37,43 | 2,27M | - |
| 2026-01-09 | Ms. Dana BoyleCAO | 1,67k | 0,00 | Derivative Exercise and Retained Stock | - | 48,45k | 3,57% |
| 2026-01-09 | Ms. Dana BoyleCAO | -11,05k | 413,49k | Derivative Exercise and Sale | 37,43 | 48,45k | - |
| 2026-01-09 | Dr. Rajeev SaggarChief Medical Officer | 334,00 | 0,00 | Derivative Exercise and Retained Stock | - | 73,97k | 0,45% |
| 2026-01-09 | Dr. Rajeev SaggarChief Medical Officer | -21,14k | 791,35k | Derivative Exercise and Sale | 37,43 | 73,97k | - |
| 2025-11-28 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | 1,27k | 0,00 | Derivative Exercise and Retained Stock | - | 394,74k | 0,32% |
| 2025-11-28 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | -1,07k | 34,51k | Derivative Exercise and Sale | 32,19 | 394,74k | - |
| 2025-11-28 | Mr. Michael KasetaCOO & CFO | 1,18k | 0,00 | Derivative Exercise and Retained Stock | - | 121,49k | 0,98% |
| 2025-11-28 | Mr. Michael KasetaCOO & CFO | -1,17k | 37,53k | Derivative Exercise and Sale | 32,19 | 121,49k | - |
| 2025-12-01 | Ms. Sarah KreppChief HR Officer | -221,00 | 7,11k | Automatic Disposition | 32,19 | 24,09k | -0,91% |
| 2025-12-01 | Ms. Dana BoyleCAO | -303,00 | 9,75k | Automatic Disposition | 32,19 | 30,49k | -0,98% |
| 2025-11-28 | Mr. Jason AdairChief Business Officer | 870,00 | 0,00 | Derivative Exercise and Retained Stock | - | 80,77k | 1,09% |
| 2025-11-28 | Mr. Jason AdairChief Business Officer | -693,00 | 22,31k | Derivative Exercise and Sale | 32,19 | 80,77k | - |
| 2025-11-28 | Mr. Scott MoomawChief Commercial Officer | 1,04k | 0,00 | Derivative Exercise and Retained Stock | - | 30,77k | 3,51% |
| 2025-11-28 | Mr. Scott MoomawChief Commercial Officer | -831,00 | 26,75k | Derivative Exercise and Sale | 32,19 | 30,77k | - |
| 2025-11-18 | Mr. Jason AdairChief Business Officer | -35,66k | 860,70k | Derivative Exercise and Sale | 5,89 - 30,03 | 79,90k | - |
| 2025-11-07 | Ms. Dana BoyleCAO | -29,00k | 727,67k | Verkauf | 25,06 - 25,16 | 54,85k | -34,59% |
| 2025-11-05 | Dr. Rajeev SaggarChief Medical Officer | -71,38k | 1,93M | Verkauf | 27,00 | 46,95k | -60,32% |
| 2025-10-27 | Mr. Jason AdairChief Business Officer | -692,00 | 15,87k | Automatic Disposition | 22,93 | 79,90k | -0,86% |
| 2025-10-27 | Ms. Dana BoyleCAO | -1,07k | 24,60k | Automatic Disposition | 22,93 | 58,86k | -1,79% |
| 2025-10-10 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | -3,76k | 87,97k | Derivative Exercise and Sale | 23,41 | 393,47k | - |
| 2025-10-13 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | -4,08k | 95,54k | Automatic Disposition | 23,41 | 393,47k | -1,03% |
| 2025-10-10 | Mr. Michael KasetaCOO & CFO | -5,83k | 136,43k | Derivative Exercise and Sale | 23,41 | 120,32k | - |
| 2025-10-13 | Mr. Michael KasetaCOO & CFO | -5,80k | 135,82k | Automatic Disposition | 23,41 | 120,32k | -4,60% |
| 2025-10-10 | Dr. Rajeev SaggarChief Medical Officer | -3,53k | 82,64k | Derivative Exercise and Sale | 23,41 | 118,33k | - |
| 2025-10-13 | Dr. Rajeev SaggarChief Medical Officer | -1,80k | 42,07k | Automatic Disposition | 23,41 | 118,33k | -1,50% |
| 2025-10-10 | Mr. Scott MoomawChief Commercial Officer | -3,11k | 72,76k | Derivative Exercise and Sale | 23,41 | 29,72k | - |
| 2025-10-13 | Mr. Scott MoomawChief Commercial Officer | -1,79k | 41,95k | Verkauf | 23,41 | 29,72k | -5,69% |
| 2025-10-13 | Ms. Dana BoyleCAO | -1,24k | 28,98k | Automatic Disposition | 23,41 | 56,81k | -2,13% |
| 2025-10-10 | Dr. Roger A. JeffsCEO & Director | -13,83k | 323,85k | Derivative Exercise and Sale | 23,41 | 2,18M | - |
| 2025-10-13 | Dr. Roger A. JeffsCEO & Director | -6,43k | 150,46k | Automatic Disposition | 23,41 | 2,18M | -0,29% |
| 2025-10-10 | Mr. Jason AdairChief Business Officer | 2,71k | 0,00 | Derivative Exercise and Retained Stock | - | 79,03k | 3,55% |
| 2025-10-10 | Mr. Jason AdairChief Business Officer | -3,67k | 85,91k | Derivative Exercise and Sale | 23,41 | 79,03k | - |
| 2025-10-13 | Ms. Sarah KreppChief HR Officer | -1,69k | 39,59k | Automatic Disposition | 23,41 | 23,69k | -6,66% |
| 2025-09-15 | Mr. Ramandeep SinghIndependent Director | -45,52k | 1,06M | Derivative Exercise and Sale | 2,51 - 25,81 | 12,86k | - |
| 2025-09-03 | Mr. Ramandeep SinghIndependent Director | -7,50k | 220,65k | Verkauf | 29,42 | 12,86k | -36,84% |
| 2025-08-29 | Mr. Scott MoomawChief Commercial Officer | -1,88k | 53,96k | Derivative Exercise and Sale | 28,62 - 29,05 | 23,20k | - |
| 2025-09-02 | Mr. Scott MoomawChief Commercial Officer | -68,82k | 1,97M | Automatic Disposition | 28,62 | 23,20k | -74,79% |
| 2025-08-29 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | 1,28k | 0,00 | Derivative Exercise and Retained Stock | - | 384,16k | 0,33% |
| 2025-08-29 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | -1,06k | 30,88k | Derivative Exercise and Sale | 29,05 | 384,16k | - |
| 2025-08-29 | Mr. Michael KasetaCOO & CFO | 1,20k | 0,00 | Derivative Exercise and Retained Stock | - | 109,37k | 1,11% |
| 2025-08-29 | Mr. Michael KasetaCOO & CFO | -1,15k | 33,35k | Derivative Exercise and Sale | 29,05 | 109,37k | - |
| 2025-08-29 | Ms. Sarah KreppChief HR Officer | -209,00 | 6,07k | Automatic Disposition | 29,05 | 21,39k | -0,97% |
| 2025-08-29 | Ms. Dana BoyleCAO | -296,00 | 8,60k | Automatic Disposition | 29,05 | 54,48k | -0,54% |
| 2025-08-28 | Mr. Paul B. ManningIndependent Director | -670,84k | 18,96M | Verkauf | 27,62 - 29,14 | 5,50M | -10,88% |
| 2025-08-29 | Mr. Jason AdairChief Business Officer | 1,56k | 0,00 | Derivative Exercise and Retained Stock | - | 72,28k | 2,21% |
| 2025-07-11 | Mr. Jason AdairChief Business Officer | -3,91k | 108,81k | Derivative Exercise and Sale | 27,86 | 72,28k | - |
| 2025-08-28 | Mr. Jason AdairChief Business Officer | -22,60k | 630,15k | Automatic Disposition | 27,86 - 29,05 | 72,28k | -23,82% |
| 2025-08-28 | Dr. Rajeev SaggarChief Medical Officer | -20,00k | 557,07k | Automatic Disposition | 27,85 | 111,39k | -15,22% |
| 2025-08-19 | Dr. Joanna Caroline HorobinIndependent Director | -5,00k | 135,85k | Verkauf | 27,17 | 15,36k | -24,56% |
| 2025-08-15 | Mr. Michael KasetaCOO & CFO | -20,00k | 523,67k | Automatic Disposition | 26,18 | 107,33k | -15,71% |
| 2025-08-05 | Mr. Michael KasetaCOO & CFO | -30,00k | 600,13k | Automatic Disposition | 20,00 | 127,33k | -19,07% |
| 2025-07-28 | Mr. Jason AdairChief Business Officer | -454,00 | 8,87k | Automatic Disposition | 19,54 | 94,04k | -0,48% |
| 2025-07-28 | Ms. Dana BoyleCAO | -1,06k | 20,77k | Automatic Disposition | 19,54 | 52,99k | -1,97% |
| 2025-07-21 | Dr. Rajeev SaggarChief Medical Officer | -2,53k | 36,73k | Automatic Disposition | 14,54 | 130,55k | -1,90% |
| 2025-07-11 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | -3,76k | 53,68k | Derivative Exercise and Sale | 14,28 | 382,04k | - |
| 2025-07-14 | Mr. Russell SchundlerGeneral Counsel & Corporate Secretary | -4,08k | 58,22k | Automatic Disposition | 14,28 | 382,04k | -1,06% |
| 2025-07-11 | Mr. Scott MoomawChief Commercial Officer | -3,11k | 44,37k | Derivative Exercise and Sale | 14,28 | 91,18k | - |
| 2025-07-14 | Mr. Scott MoomawChief Commercial Officer | -1,69k | 24,13k | Automatic Disposition | 14,28 | 91,18k | -1,82% |
| 2025-07-11 | Dr. Rajeev SaggarChief Medical Officer | -3,53k | 50,42k | Derivative Exercise and Sale | 14,28 | 127,21k | - |
| 2025-07-14 | Dr. Rajeev SaggarChief Medical Officer | -1,80k | 25,65k | Automatic Disposition | 14,28 | 127,21k | -1,39% |
| 2025-07-14 | Ms. Sarah KreppChief HR Officer | -2,67k | 38,17k | Automatic Disposition | 14,28 | 20,13k | -11,72% |
| 2025-07-11 | Dr. Roger A. JeffsCEO & Director | -13,83k | 197,54k | Derivative Exercise and Sale | 14,28 | 2,15M | - |
| 2025-07-14 | Dr. Roger A. JeffsCEO & Director | -6,42k | 91,66k | Automatic Disposition | 14,28 | 2,15M | -0,30% |
| 2025-07-11 | Mr. Michael KasetaCOO & CFO | -5,83k | 83,22k | Derivative Exercise and Sale | 14,28 | 157,33k | - |
| 2025-07-14 | Mr. Michael KasetaCOO & CFO | -5,75k | 82,14k | Automatic Disposition | 14,28 | 157,33k | -3,53% |
| 2025-07-14 | Ms. Dana BoyleCAO | -1,19k | 17,04k | Automatic Disposition | 14,28 | 50,93k | -2,29% |
| 2025-07-11 | Mr. Jason AdairChief Business Officer | -2,48k | 35,34k | Derivative Exercise and Sale | 14,28 | 92,94k | - |
| 2025-07-14 | Mr. Jason AdairChief Business Officer | -101,00 | 1,44k | Automatic Disposition | 14,28 | 92,94k | -0,11% |