| FMR LLC | Institution | 25.466.269 | 13,71% | US$ 748,45M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 7.687.638 | 4,14% | US$ 225,94M | 2026-03-31 |
| Suvretta Capital Management, LLC | Institution | 7.581.029 | 4,08% | US$ 222,81M | 2026-03-31 |
| Hillhouse Investment Management, Ltd. | Institution | 6.065.950 | 3,27% | US$ 178,28M | 2026-03-31 |
| Westfield Capital Management Company, L.P. | Institution | 5.763.475 | 3,10% | US$ 169,39M | 2026-03-31 |
| BlackRock, Inc. | Institution | 4.684.543 | 2,52% | US$ 137,68M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 3.886.017 | 2,09% | US$ 114,21M | 2026-03-31 |
| First Beijing Investment Ltd. | Institution | 2.296.335 | 1,24% | US$ 67,49M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 2.254.488 | 1,21% | US$ 66,26M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.890.396 | 1,02% | US$ 55,56M | 2026-03-31 |
| Kynam Capital Management, LP | Institution | 1.576.295 | 0,85% | US$ 46,33M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 1.527.336 | 0,82% | US$ 44,89M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.498.372 | 0,81% | US$ 44,04M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.464.112 | 0,79% | US$ 43,03M | 2026-03-31 |
| Davern Capital Partners, LP | Institution | 1.314.748 | 0,71% | US$ 38,64M | 2026-03-31 |
| Patient Square Capital, LP | Institution | 990.000 | 0,53% | US$ 29,10M | 2026-03-31 |
| Matthews International Capital Management, LLC | Institution | 925.920 | 0,50% | US$ 27,21M | 2026-03-31 |
| Hudson Bay Capital Management LP | Institution | 876.351 | 0,47% | US$ 25,76M | 2026-03-31 |
| Johnson & Johnson Innovation - JJDC, Inc. | Institution | 814.586 | 0,44% | US$ 23,94M | 2026-03-31 |
| IvyRock Asset Management (HK) Limited | Institution | 804.000 | 0,43% | US$ 23,63M | 2026-03-31 |
| ArrowMark Colorado Holdings, LLC | Institution | 727.144 | 0,39% | US$ 21,37M | 2026-03-31 |
| Capital Research and Management Company | Institution | 647.850 | 0,35% | US$ 19,04M | 2026-03-31 |
| Triata Capital Limited | Institution | 629.914 | 0,34% | US$ 18,51M | 2026-03-31 |
| Massachusetts Financial Services Company | Institution | 574.898 | 0,31% | US$ 16,90M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 550.051 | 0,30% | US$ 16,17M | 2026-03-31 |
| SG Americas Securities, LLC | Institution | 535.658 | 0,29% | US$ 15,74M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 521.800 | 0,28% | US$ 15,34M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 516.980 | 0,28% | US$ 15,19M | 2026-03-31 |
| Leap Investments LP | Institution | 516.448 | 0,28% | US$ 15,18M | 2026-03-31 |
| Squarepoint OPS LLC | Institution | 479.480 | 0,26% | US$ 14,09M | 2026-03-31 |