| Janus Henderson Group plc | Institution | 3.784.055 | 13,01% | US$ 55,89M | 2026-03-31 |
| BlackRock, Inc. | Institution | 3.103.768 | 10,67% | US$ 45,84M | 2026-03-31 |
| Janus Henderson Biotech Innovation Master Fund Limited | Institution | 2.959.525 | 10,18% | US$ 43,71M | 2025-10-31 |
| Farallon Capital Management, L.L.C. | Institution | 2.871.862 | 9,88% | US$ 42,42M | 2026-03-31 |
| Krensavage Asset Management, LLC | Institution | 2.866.138 | 9,86% | US$ 42,33M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 1.956.867 | 6,73% | US$ 28,90M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 1.484.513 | 5,11% | US$ 21,93M | 2025-10-02 |
| Vanguard Capital Management, LLC | Institution | 1.178.049 | 4,05% | US$ 17,40M | 2026-03-31 |
| Farallon Capital Offshore Investors II, L.P | Institution | 1.110.733 | 3,82% | US$ 16,41M | 2025-12-31 |
| Vanguard Portfolio Management, LLC | Institution | 948.904 | 3,26% | US$ 14,02M | 2026-03-31 |
| Spruce Street Capital LP | Institution | 932.598 | 3,21% | US$ 13,77M | 2026-03-31 |
| Millennium Management LLC | Institution | 882.097 | 3,03% | US$ 13,03M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 880.023 | 3,03% | US$ 13,00M | 2026-03-31 |
| Dr. Jay Luly | Insider | 856.121 | 2,94% | US$ 12,64M | 2026-02-12 |
| Geode Capital Management, LLC | Institution | 725.061 | 2,49% | US$ 10,71M | 2026-03-31 |
| Integrated Core Strategies (US) LLC | Institution | 665.953 | 2,29% | US$ 9,84M | 2025-12-31 |
| Renaissance Technologies LLC | Institution | 665.258 | 2,29% | US$ 9,83M | 2026-03-31 |
| Farallon Capital Institutional Partners, L.P. | Institution | 595.851 | 2,05% | US$ 8,80M | 2025-12-31 |
| State Street Global Advisors, Inc. | Institution | 562.106 | 1,93% | US$ 8,30M | 2026-03-31 |
| Farallon Capital Partners, L.P. | Institution | 531.119 | 1,83% | US$ 7,84M | 2025-12-31 |
| Hillsdale Investment Management Inc. | Institution | 435.510 | 1,50% | US$ 6,43M | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 302.121 | 1,04% | US$ 4,46M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 294.971 | 1,01% | US$ 4,36M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 267.364 | 0,92% | US$ 3,95M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 262.533 | 0,90% | US$ 3,88M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 240.968 | 0,83% | US$ 3,56M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 210.793 | 0,72% | US$ 3,11M | 2026-03-31 |
| Marshall Wace LLP | Institution | 210.070 | 0,72% | US$ 3,10M | 2026-03-31 |
| Eaton Vance Management | Institution | 208.521 | 0,72% | US$ 3,08M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 203.252 | 0,70% | US$ 3,00M | 2026-03-31 |
| Farallon Capital F5 Master I, L.P. | Institution | 176.083 | 0,61% | US$ 2,60M | 2025-12-31 |
| Vanguard Fiduciary Trust Company | Institution | 175.856 | 0,60% | US$ 2,60M | 2026-03-31 |
| Invesco Capital Management LLC | Institution | 156.007 | 0,54% | US$ 2,30M | 2026-03-31 |
| Farallon Capital Institutional Partners II, L.P. | Institution | 150.355 | 0,52% | US$ 2,22M | 2025-12-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 125.759 | 0,43% | US$ 1,86M | 2026-03-31 |