| FMR LLC | Institution | 7.767.686 | 14,21% | US$ 660,02M | 2026-03-31 |
| BlackRock, Inc. | Institution | 3.175.677 | 5,81% | US$ 269,84M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 2.595.783 | 4,75% | US$ 220,56M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 2.439.130 | 4,46% | US$ 207,25M | 2026-03-31 |
| Sirenia Capital Management LP | Institution | 2.298.122 | 4,20% | US$ 195,27M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.031.249 | 3,72% | US$ 172,60M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.610.483 | 2,95% | US$ 136,84M | 2026-03-31 |
| Tellus BioVentures, LLC | Institution | 1.436.745 | 2,63% | US$ 122,08M | 2025-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.398.913 | 2,56% | US$ 118,87M | 2026-03-31 |
| 5AM Ventures VII, L.P. | Institution | 1.231.619 | 2,25% | US$ 104,65M | 2024-09-30 |
| Fred Alger Management, LLC | Institution | 1.161.923 | 2,13% | US$ 98,73M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 1.076.009 | 1,97% | US$ 91,43M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 961.585 | 1,76% | US$ 81,71M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 916.211 | 1,68% | US$ 77,85M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 852.164 | 1,56% | US$ 72,41M | 2026-03-31 |
| UBS Asset Management AG | Institution | 841.717 | 1,54% | US$ 71,52M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 836.000 | 1,53% | US$ 71,03M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 834.383 | 1,53% | US$ 70,90M | 2025-12-31 |
| Point72 Asset Management, L.P. | Institution | 643.599 | 1,18% | US$ 54,69M | 2026-03-31 |
| Jennison Associates LLC | Institution | 485.136 | 0,89% | US$ 41,22M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 474.085 | 0,87% | US$ 40,28M | 2026-03-31 |
| Woodline Partners LP | Institution | 433.457 | 0,79% | US$ 36,83M | 2026-03-31 |
| Samlyn Capital, LLC | Institution | 431.115 | 0,79% | US$ 36,63M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 382.121 | 0,70% | US$ 32,47M | 2026-03-31 |
| Barclays Bank PLC | Institution | 373.426 | 0,68% | US$ 31,73M | 2026-03-31 |
| Spruce Street Capital LP | Institution | 373.274 | 0,68% | US$ 31,72M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 359.672 | 0,66% | US$ 30,56M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 358.470 | 0,66% | US$ 30,46M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 349.381 | 0,64% | US$ 29,69M | 2026-03-31 |
| Marshall Wace LLP | Institution | 341.929 | 0,63% | US$ 29,05M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 325.440 | 0,60% | US$ 27,65M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 317.312 | 0,58% | US$ 26,96M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 305.440 | 0,56% | US$ 25,95M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 303.752 | 0,56% | US$ 25,81M | 2026-03-31 |
| Lord, Abbett & Co. LLC | Institution | 299.210 | 0,55% | US$ 25,42M | 2026-03-31 |
| Norges Bank Investment Management | Institution | 285.609 | 0,52% | US$ 24,27M | 2025-12-31 |