| FMR LLC | Institution | 7.767.686 | 14,21% | US$ 705,31M | 2026-03-31 |
| BlackRock, Inc. | Institution | 3.175.677 | 5,81% | US$ 288,35M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 2.981.674 | 5,45% | US$ 270,74M | 2026-02-13 |
| RA Capital Healthcare Fund, L.P. | Institution | 2.866.733 | 5,24% | US$ 260,30M | 2025-09-30 |
| RA Capital Management, L.P. | Institution | 2.611.733 | 4,78% | US$ 237,15M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 2.595.783 | 4,75% | US$ 235,70M | 2026-03-31 |
| Fairmount Funds Management LLC | Institution | 2.537.191 | 4,64% | US$ 230,38M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 2.439.130 | 4,46% | US$ 221,47M | 2026-03-31 |
| Sirenia Capital Management LP | Institution | 2.298.122 | 4,20% | US$ 208,67M | 2026-03-31 |
| Fairmount Healthcare Fund II L.P. | Institution | 2.137.191 | 3,91% | US$ 194,06M | 2025-11-21 |
| Avidity Partners Management, L.P. | Institution | 2.104.184 | 3,85% | US$ 191,06M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.031.249 | 3,72% | US$ 184,44M | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 1.946.667 | 3,56% | US$ 176,76M | 2026-03-31 |
| Octagon Investments Master Fund LP | Institution | 1.818.500 | 3,33% | US$ 165,12M | 2024-12-31 |
| TCG Crossover Management, LLC | Institution | 1.676.624 | 3,07% | US$ 152,24M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.610.483 | 2,95% | US$ 146,23M | 2026-03-31 |
| TCG Crossover Fund II, L.P. | Institution | 1.501.624 | 2,75% | US$ 136,35M | 2025-03-31 |
| Tellus BioVentures, LLC | Institution | 1.436.745 | 2,63% | US$ 130,46M | 2025-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.398.913 | 2,56% | US$ 127,02M | 2026-03-31 |
| Bain Capital Life Sciences Fund III, L.P. | Institution | 1.315.892 | 2,41% | US$ 119,48M | 2025-09-30 |
| 5AM Ventures VII, L.P. | Institution | 1.231.619 | 2,25% | US$ 111,83M | 2024-09-30 |
| VR Management, LLC | Institution | 1.180.000 | 2,16% | US$ 107,14M | 2026-03-31 |
| Fred Alger Management, LLC | Institution | 1.161.923 | 2,13% | US$ 105,50M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 1.076.009 | 1,97% | US$ 97,70M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 1.019.813 | 1,87% | US$ 92,60M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 961.585 | 1,76% | US$ 87,31M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 950.000 | 1,74% | US$ 86,26M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 926.071 | 1,69% | US$ 84,09M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 916.211 | 1,68% | US$ 83,19M | 2026-03-31 |
| Braidwell LP | Institution | 899.364 | 1,65% | US$ 81,66M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 852.164 | 1,56% | US$ 77,38M | 2026-03-31 |
| UBS Asset Management AG | Institution | 841.717 | 1,54% | US$ 76,43M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 836.000 | 1,53% | US$ 75,91M | 2026-03-31 |
| Silverarc Capital Management, LLC | Institution | 654.746 | 1,20% | US$ 59,45M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 643.599 | 1,18% | US$ 58,44M | 2026-03-31 |
| Catalio Capital Management, LP | Institution | 560.308 | 1,02% | US$ 50,88M | 2026-03-31 |
| Jennison Associates LLC | Institution | 485.136 | 0,89% | US$ 44,05M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 474.085 | 0,87% | US$ 43,05M | 2026-03-31 |
| Woodline Partners LP | Institution | 433.457 | 0,79% | US$ 39,36M | 2026-03-31 |