| FMR LLC | Institution | 23.122.660 | 13,53% | US$ 889,76M | 2026-03-31 |
| BlackRock, Inc. | Institution | 16.045.014 | 9,39% | US$ 617,41M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 9.602.000 | 5,62% | US$ 369,48M | 2025-09-30 |
| Deerfield Management Company, L.P. | Institution | 9.043.903 | 5,29% | US$ 348,01M | 2026-03-31 |
| Deerfield Partners, LP | Institution | 9.043.903 | 5,29% | US$ 348,01M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 7.333.333 | 4,29% | US$ 282,19M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 6.894.959 | 4,03% | US$ 265,32M | 2026-03-31 |
| The Column Group, LLC | Institution | 6.798.162 | 3,98% | US$ 261,59M | 2025-09-30 |
| TCG Crossover Fund I, L.P. | Institution | 6.798.162 | 3,98% | US$ 261,59M | 2025-09-30 |
| Janus Henderson Group plc | Institution | 5.965.125 | 3,49% | US$ 229,54M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 5.926.826 | 3,47% | US$ 228,06M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 5.663.543 | 3,31% | US$ 217,93M | 2026-03-31 |
| Fairmount Funds Management LLC | Institution | 5.542.832 | 3,24% | US$ 213,29M | 2026-03-31 |
| Fairmount Healthcare Fund II L.P. | Institution | 5.542.832 | 3,24% | US$ 213,29M | 2026-03-31 |
| RTW Investments, LP | Institution | 5.458.675 | 3,19% | US$ 210,05M | 2026-03-31 |
| Commodore Capital LP | Institution | 5.240.007 | 3,07% | US$ 201,64M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 4.946.894 | 2,89% | US$ 190,36M | 2026-03-31 |
| Paradigm BioCapital International Fund Ltd. | Institution | 4.906.897 | 2,87% | US$ 188,82M | 2025-02-05 |
| Kynam Capital Management, LP | Institution | 4.037.331 | 2,36% | US$ 155,36M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 4.032.988 | 2,36% | US$ 155,19M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 3.699.519 | 2,16% | US$ 142,36M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 3.578.622 | 2,09% | US$ 137,71M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 3.212.815 | 1,88% | US$ 123,63M | 2026-03-31 |
| Lord, Abbett & Co. LLC | Institution | 3.181.270 | 1,86% | US$ 122,42M | 2026-03-31 |
| Emerald Advisers, LLC | Institution | 2.616.964 | 1,53% | US$ 100,70M | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 2.350.000 | 1,37% | US$ 90,43M | 2026-03-31 |
| Invesco Ltd. | Institution | 2.259.649 | 1,32% | US$ 86,95M | 2026-03-31 |
| Holocene Advisors, LP | Institution | 2.250.196 | 1,32% | US$ 86,59M | 2026-03-31 |
| Sofinnova Investments, Inc. | Institution | 2.113.551 | 1,24% | US$ 81,33M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 2.084.386 | 1,22% | US$ 80,21M | 2025-06-30 |
| VR Management, LLC | Institution | 2.000.000 | 1,17% | US$ 76,96M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 1.868.389 | 1,09% | US$ 71,90M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 1.798.768 | 1,05% | US$ 69,22M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.714.927 | 1,00% | US$ 65,99M | 2026-03-31 |
| Artal Group S.A. | Institution | 1.709.279 | 1,00% | US$ 65,77M | 2026-03-31 |
| Marshall Wace LLP | Institution | 1.600.168 | 0,94% | US$ 61,57M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 1.516.297 | 0,89% | US$ 58,35M | 2026-03-31 |
| Woodline Partners LP | Institution | 1.509.557 | 0,88% | US$ 58,09M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 1.422.666 | 0,83% | US$ 54,74M | 2025-06-30 |