| BML Capital Management, LLC | Institution | 13.950.000 | 9,99% | US$ 68,49M | 2026-04-23 |
| BML Investment Partners, L.P. | Institution | 13.950.000 | 9,99% | US$ 68,49M | 2026-04-23 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 9.345.000 | 6,69% | US$ 45,88M | 2026-03-09 |
| Deep Track Capital, LP | Institution | 9.345.000 | 6,69% | US$ 45,88M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 7.626.705 | 5,46% | US$ 37,45M | 2026-03-31 |
| BlackRock, Inc. | Institution | 7.407.065 | 5,30% | US$ 36,37M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 6.804.072 | 4,87% | US$ 33,41M | 2026-03-31 |
| Vivo Capital, LLC | Institution | 6.666.666 | 4,77% | US$ 32,73M | 2026-03-31 |
| Vivo Opportunity Fund Holdings, L.P | Institution | 5.966.370 | 4,27% | US$ 29,29M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 5.278.144 | 3,78% | US$ 25,92M | 2025-09-30 |
| Vanguard Capital Management, LLC | Institution | 5.167.469 | 3,70% | US$ 25,37M | 2026-03-31 |
| Frazier Life Sciences Management, LP | Institution | 4.925.374 | 3,53% | US$ 24,18M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 4.472.650 | 3,20% | US$ 21,96M | 2026-03-31 |
| Decheng Capital LLC | Institution | 4.041.736 | 2,89% | US$ 19,84M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 3.871.000 | 2,77% | US$ 19,01M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 3.361.328 | 2,41% | US$ 16,50M | 2026-03-31 |
| Morgan Stanley | Institution | 2.719.179 | 1,95% | US$ 13,35M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2.423.691 | 1,74% | US$ 11,90M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 2.249.319 | 1,61% | US$ 11,04M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.008.746 | 1,44% | US$ 9,86M | 2026-03-31 |
| Kalehua Capital Management LLC | Institution | 1.832.365 | 1,31% | US$ 9,00M | 2026-03-31 |
| Braidwell LP | Institution | 1.699.116 | 1,22% | US$ 8,34M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.656.066 | 1,19% | US$ 8,13M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 1.613.430 | 1,16% | US$ 7,92M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 1.539.791 | 1,10% | US$ 7,56M | 2026-03-31 |
| Woodline Partners LP | Institution | 1.485.623 | 1,06% | US$ 7,29M | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 1.418.360 | 1,02% | US$ 6,96M | 2026-03-31 |
| Four Pines Master Fund LP | Institution | 1.064.861 | 0,76% | US$ 5,23M | 2024-11-18 |
| Deutsche Asset & Wealth Management | Institution | 997.850 | 0,71% | US$ 4,90M | 2026-03-31 |
| Aldebaran Capital, LLC | Institution | 947.162 | 0,68% | US$ 4,65M | 2026-03-31 |
| Vivo Asia Opportunity Fund Holdings, Lp | Institution | 933.728 | 0,67% | US$ 4,58M | 2024-11-19 |
| D. E. Shaw & Co., L.P. | Institution | 900.804 | 0,64% | US$ 4,42M | 2026-03-31 |
| Millennium Management LLC | Institution | 756.127 | 0,54% | US$ 3,71M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 728.225 | 0,52% | US$ 3,58M | 2026-03-31 |
| Three Bridge Wealth Advisors, LLC | Institution | 714.823 | 0,51% | US$ 3,51M | 2026-03-31 |
| Marshall Wace LLP | Institution | 712.984 | 0,51% | US$ 3,50M | 2026-03-31 |
| Vivo Opportunity Cayman Fund,L.P. | Institution | 700.296 | 0,50% | US$ 3,44M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 628.859 | 0,45% | US$ 3,09M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 511.461 | 0,37% | US$ 2,51M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 502.631 | 0,36% | US$ 2,47M | 2026-03-31 |