| 2026-05-21 | Dr. Mark StetterIndependent Director | 1,57k | 0,00 | Derivative Exercise and Retained Stock | - | 1,57k | - |
| 2026-05-20 | Ms. Louise M. ParentInsider | 12,13k | 0,00 | Derivative Exercise and Retained Stock | - | 28,39k | 74,58% |
| 2026-05-13 | Mr. Frank A. D'AmelioIndependent Director | 6,65k | 501,34k | Kauf | 75,39 | 21,46k | 44,91% |
| 2026-05-13 | Mr. Paul M. BisaroIndependent Director | 2,00k | 151,75k | Kauf | 75,88 | 27,86k | 7,73% |
| 2026-05-11 | Mr. Michael Benedict McCAllisterIndependent Non-Executive Chairman | 3,00k | 233,27k | Kauf | 77,76 | 31,89k | 10,38% |
| 2026-04-30 | Dr. Kevin EschExec. VP and President of Research & Development | -75,00 | 8,62k | Derivative Exercise and Sale | 114,97 | 702,00 | - |
| 2026-04-30 | Dr. Kevin EschExec. VP and President of Research & Development | 184,00 | 0,00 | Derivative Exercise and Retained Stock | - | 702,00 | 35,52% |
| 2026-03-31 | Mr. Keith SarbaughExec. VP & Chief Digital and Technology Officer | -524,00 | 61,94k | Derivative Exercise and Sale | 118,21 | 3,35k | - |
| 2026-03-31 | Mr. Keith SarbaughExec. VP & Chief Digital and Technology Officer | 1,00k | 0,00 | Derivative Exercise and Retained Stock | - | 3,35k | 42,87% |
| 2026-03-09 | Mr. Gregory NordenIndependent Director | -1,21k | 0,00 | Other Disposition | - | 18,17k | -6,26% |
| 2026-02-19 | Ms. Julie A. FullerExec. VP, Chief HR Officer & Global Operations | 460,00 | 0,00 | Derivative Exercise and Retained Stock | - | 1,06k | 76,29% |
| 2026-02-19 | Ms. Julie A. FullerExec. VP, Chief HR Officer & Global Operations | -290,00 | 36,91k | Derivative Exercise and Sale | 127,28 | 1,06k | - |
| 2026-02-19 | Mr. Wetteny N. JosephExec. VP & CFO | 1,35k | 0,00 | Derivative Exercise and Retained Stock | - | 22,11k | 6,49% |
| 2026-02-19 | Mr. Wetteny N. JosephExec. VP & CFO | -703,00 | 89,48k | Derivative Exercise and Sale | 127,28 | 22,11k | - |
| 2026-02-19 | Mr. Gregory NordenIndependent Director | 1,21k | 0,00 | Derivative Exercise and Retained Stock | - | 18,17k | 7,15% |
| 2026-02-19 | Mr. Gregory NordenIndependent Director | -406,00 | 51,68k | Derivative Exercise and Sale | 127,28 | 18,17k | - |
| 2026-02-19 | Mr. Michael Benedict McCAllisterIndependent Non-Executive Chairman | 1,21k | 0,00 | Derivative Exercise and Retained Stock | - | 28,89k | 4,36% |
| 2026-02-19 | Mr. Michael Benedict McCAllisterIndependent Non-Executive Chairman | -413,00 | 52,57k | Derivative Exercise and Sale | 127,28 | 28,89k | - |
| 2026-02-19 | Ms. Vanessa BroadhurstIndependent Director | 1,10k | 0,00 | Derivative Exercise and Retained Stock | - | 3,92k | 39,11% |
| 2026-02-19 | Ms. Vanessa BroadhurstIndependent Director | -517,00 | 65,80k | Derivative Exercise and Sale | 127,28 | 3,92k | - |
| 2026-02-19 | Dr. Kevin EschExec. VP and President of Research & Development | 67,00 | 0,00 | Derivative Exercise and Retained Stock | - | 517,00 | 14,89% |
| 2026-02-19 | Dr. Kevin EschExec. VP and President of Research & Development | -35,00 | 4,45k | Derivative Exercise and Sale | 127,28 | 517,00 | - |
| 2026-02-19 | Mr. Keith SarbaughExec. VP & Chief Digital and Technology Officer | 232,00 | 0,00 | Derivative Exercise and Retained Stock | - | 2,34k | 11,00% |
| 2026-02-19 | Mr. Keith SarbaughExec. VP & Chief Digital and Technology Officer | -154,00 | 19,60k | Derivative Exercise and Sale | 127,28 | 2,34k | - |
| 2026-02-19 | Mr. Jamie BrannanExec. VP & Chief Commercial Officer | 638,00 | 0,00 | Derivative Exercise and Retained Stock | - | 3,74k | 20,60% |
| 2026-02-19 | Mr. Jamie BrannanExec. VP & Chief Commercial Officer | -566,00 | 72,04k | Derivative Exercise and Sale | 127,28 | 3,74k | - |
| 2026-02-19 | Mr. Nick AshtonExec. VP and President of Global Manufacturing & Supply | 358,00 | 0,00 | Derivative Exercise and Retained Stock | - | 1,82k | 24,45% |
| 2026-02-19 | Mr. Nick AshtonExec. VP and President of Global Manufacturing & Supply | -392,00 | 49,89k | Derivative Exercise and Sale | 127,28 | 1,82k | - |
| 2026-02-19 | Ms. Roxanne LaganoExec. VP, General Counsel & Corporate Secretary | 492,00 | 0,00 | Derivative Exercise and Retained Stock | - | 16,47k | 3,08% |
| 2026-02-19 | Ms. Roxanne LaganoExec. VP, General Counsel & Corporate Secretary | -258,00 | 32,84k | Derivative Exercise and Sale | 127,28 | 16,47k | - |
| 2026-02-19 | Mr. Gavin D. K. HattersleyIndependent Director | 1,14k | 0,00 | Derivative Exercise and Retained Stock | - | 3,35k | 51,35% |
| 2026-02-19 | Mr. Gavin D. K. HattersleyIndependent Director | -481,00 | 61,22k | Derivative Exercise and Sale | 127,28 | 3,35k | - |
| 2026-02-19 | Ms. Kristin C. PeckCEO & Director | 3,73k | 0,00 | Derivative Exercise and Retained Stock | - | 105,90k | 3,65% |
| 2026-02-19 | Ms. Kristin C. PeckCEO & Director | -3,62k | 461,14k | Derivative Exercise and Sale | 127,28 | 105,90k | - |
| 2026-02-19 | Ms. Rimma DriscollEVP of Global Strategy, Portfolio Mktg. & Business Dev and Global BioDevices & Platinum Performance | 275,00 | 0,00 | Derivative Exercise and Retained Stock | - | 5,72k | 5,06% |
| 2026-02-19 | Ms. Rimma DriscollEVP of Global Strategy, Portfolio Mktg. & Business Dev and Global BioDevices & Platinum Performance | -179,00 | 22,78k | Derivative Exercise and Sale | 127,28 | 5,72k | - |
| 2026-02-19 | Ms. Jeannette Ferran AstorgaExec. VP of Corporate Affairs & Chief Sustainability Officer | 241,00 | 0,00 | Derivative Exercise and Retained Stock | - | 1,68k | 16,70% |
| 2026-02-19 | Ms. Jeannette Ferran AstorgaExec. VP of Corporate Affairs & Chief Sustainability Officer | -190,00 | 24,18k | Derivative Exercise and Sale | 127,28 | 1,68k | - |
| 2026-02-19 | Ms. Louise M. ParentInsider | 1,00k | 0,00 | Derivative Exercise and Retained Stock | - | 16,26k | 6,58% |
| 2026-02-19 | Ms. Louise M. ParentInsider | -615,00 | 78,28k | Derivative Exercise and Sale | 127,28 | 16,26k | - |
| 2026-02-19 | Dr. Willie M. ReedIndependent Director | 1,62k | 0,00 | Derivative Exercise and Retained Stock | - | 12,86k | 14,40% |
| 2026-02-19 | Mr. Paul M. BisaroIndependent Director | 1,62k | 0,00 | Derivative Exercise and Retained Stock | - | 25,86k | 6,68% |
| 2026-02-19 | Dr. Antoinette Renee LeatherberryIndependent Director | 1,21k | 0,00 | Derivative Exercise and Retained Stock | - | 5,28k | 29,83% |
| 2026-02-19 | Dr. Antoinette Renee LeatherberryIndependent Director | -406,00 | 51,68k | Derivative Exercise and Sale | 127,28 | 5,28k | - |
| 2026-02-17 | Ms. Kristin C. PeckCEO & Director | -20,00k | 1,70M | Derivative Exercise and Sale | 41,83 - 127,55 | 102,17k | - |
| 2026-02-06 | Mr. Jamie BrannanExec. VP & Chief Commercial Officer | 481,00 | 0,00 | Derivative Exercise and Retained Stock | - | 3,10k | 18,39% |
| 2026-02-06 | Mr. Jamie BrannanExec. VP & Chief Commercial Officer | -428,00 | 54,54k | Derivative Exercise and Sale | 127,42 | 3,10k | - |
| 2026-02-06 | Ms. Jeannette Ferran AstorgaExec. VP of Corporate Affairs & Chief Sustainability Officer | 235,00 | 0,00 | Derivative Exercise and Retained Stock | - | 1,44k | 19,45% |
| 2026-02-06 | Ms. Jeannette Ferran AstorgaExec. VP of Corporate Affairs & Chief Sustainability Officer | -189,00 | 24,08k | Derivative Exercise and Sale | 127,42 | 1,44k | - |
| 2026-02-06 | Mr. Wetteny N. JosephExec. VP & CFO | 1,80k | 0,00 | Derivative Exercise and Retained Stock | - | 20,77k | 9,48% |
| 2026-02-06 | Mr. Wetteny N. JosephExec. VP & CFO | -998,00 | 127,17k | Derivative Exercise and Sale | 127,42 | 20,77k | - |
| 2026-02-06 | Ms. Roxanne LaganoExec. VP, General Counsel & Corporate Secretary | 711,00 | 0,00 | Derivative Exercise and Retained Stock | - | 15,97k | 4,66% |
| 2026-02-06 | Ms. Roxanne LaganoExec. VP, General Counsel & Corporate Secretary | -438,00 | 55,81k | Derivative Exercise and Sale | 127,42 | 15,97k | - |
| 2026-02-06 | Dr. Kevin EschExec. VP and President of Research & Development | 60,00 | 0,00 | Derivative Exercise and Retained Stock | - | 450,00 | 15,38% |
| 2026-02-06 | Dr. Kevin EschExec. VP and President of Research & Development | -33,00 | 4,20k | Derivative Exercise and Sale | 127,42 | 450,00 | - |
| 2026-02-06 | Mr. Nick AshtonExec. VP and President of Global Manufacturing & Supply | 370,00 | 0,00 | Derivative Exercise and Retained Stock | - | 1,46k | 33,82% |
| 2026-02-06 | Mr. Nick AshtonExec. VP and President of Global Manufacturing & Supply | -409,00 | 52,11k | Derivative Exercise and Sale | 127,42 | 1,46k | - |
| 2026-02-06 | Ms. Kristin C. PeckCEO & Director | 7,14k | 0,00 | Derivative Exercise and Retained Stock | - | 102,17k | 7,52% |
| 2026-02-06 | Ms. Kristin C. PeckCEO & Director | -4,64k | 590,72k | Derivative Exercise and Sale | 127,42 | 102,17k | - |
| 2026-02-06 | Ms. Rimma DriscollEVP of Global Strategy, Portfolio Mktg. & Business Dev and Global BioDevices & Platinum Performance | 248,00 | 0,00 | Derivative Exercise and Retained Stock | - | 5,44k | 4,78% |
| 2026-02-06 | Ms. Rimma DriscollEVP of Global Strategy, Portfolio Mktg. & Business Dev and Global BioDevices & Platinum Performance | -166,00 | 21,15k | Derivative Exercise and Sale | 127,42 | 5,44k | - |
| 2026-02-06 | Mr. Keith SarbaughExec. VP & Chief Digital and Technology Officer | 71,00 | 0,00 | Derivative Exercise and Retained Stock | - | 2,11k | 3,48% |
| 2026-02-06 | Mr. Keith SarbaughExec. VP & Chief Digital and Technology Officer | -48,00 | 6,12k | Derivative Exercise and Sale | 127,42 | 2,11k | - |
| 2025-09-30 | Ms. Julie A. FullerExec. VP, Chief HR Officer & Global Operations | 515,00 | 0,00 | Derivative Exercise and Retained Stock | - | 603,00 | 585,23% |
| 2025-09-30 | Ms. Julie A. FullerExec. VP, Chief HR Officer & Global Operations | -269,00 | 39,36k | Derivative Exercise and Sale | 146,32 | 603,00 | - |
| 2025-09-15 | Ms. Roxanne LaganoExec. VP, General Counsel & Corporate Secretary | -700,00 | 0,00 | Other Disposition | - | 15,25k | -4,39% |
| 2025-07-25 | Ms. Vanessa BroadhurstIndependent Director | 961,00 | 0,00 | Derivative Exercise and Retained Stock | - | 2,82k | 51,75% |
| 2025-07-25 | Ms. Vanessa BroadhurstIndependent Director | -451,00 | 68,61k | Derivative Exercise and Sale | 152,12 | 2,82k | - |