| RTW Investments, LP | Institution | 6.574.032 | 5,85% | US$ 125,89M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 5.913.075 | 5,26% | US$ 113,24M | 2026-06-02 |
| RA Capital Healthcare Fund, L.P. | Institution | 5.740.762 | 5,11% | US$ 109,94M | 2026-03-31 |
| FMR LLC | Institution | 5.707.450 | 5,08% | US$ 109,30M | 2026-06-11 |
| RA Capital Management, L.P. | Institution | 5.707.262 | 5,08% | US$ 109,29M | 2026-03-31 |
| Qiming Weichuang Venture Capital Management (Shanghai) Company Limited | Institution | 4.888.364 | 4,35% | US$ 93,61M | 2025-12-31 |
| Qiming Venture Partners Iv, L.P. | Institution | 4.738.741 | 4,22% | US$ 90,75M | 2025-12-31 |
| Norges Bank Investment Management | Institution | 3.868.017 | 3,44% | US$ 74,07M | 2025-12-31 |
| Vanguard Capital Management, LLC | Institution | 3.255.835 | 2,90% | US$ 62,35M | 2026-05-31 |
| Wellington Management Group LLP | Institution | 3.092.804 | 2,75% | US$ 59,23M | 2026-03-31 |
| TCG Crossover Fund II, L.P. | Institution | 2.956.533 | 2,63% | US$ 56,62M | 2026-06-02 |
| BlackRock, Inc. | Institution | 2.799.971 | 2,49% | US$ 53,62M | 2026-05-31 |
| The Goldman Sachs Group, Inc. | Institution | 2.606.421 | 2,32% | US$ 49,91M | 2026-06-11 |
| Frazier Life Sciences Management, LP | Institution | 1.902.320 | 1,69% | US$ 36,43M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.688.632 | 1,50% | US$ 32,34M | 2026-03-31 |
| Baron Capital Group, Inc. | Institution | 1.658.318 | 1,48% | US$ 31,76M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 1.425.367 | 1,27% | US$ 27,30M | 2026-03-31 |
| Yinhua Fund Management Co., Ltd. | Institution | 1.177.230 | 1,05% | US$ 22,54M | 2025-12-31 |
| China Universal Asset Management Company Ltd. | Institution | 1.045.395 | 0,93% | US$ 20,02M | 2026-03-31 |
| UBS Asset Management AG | Institution | 963.647 | 0,86% | US$ 18,45M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 880.173 | 0,78% | US$ 16,86M | 2026-05-31 |
| Bosera Asset Management Co., Ltd. | Institution | 853.520 | 0,76% | US$ 16,34M | 2025-06-30 |
| Rock Springs Capital Management LP | Institution | 814.707 | 0,73% | US$ 15,60M | 2026-03-31 |
| China Asset Management Co. Ltd. | Institution | 776.570 | 0,69% | US$ 14,87M | 2026-05-29 |
| JPMorgan Chase & Co. | Institution | 768.632 | 0,68% | US$ 14,72M | 2026-06-05 |
| Invesco Great Wall Fund Management Co. Ltd | Institution | 625.440 | 0,56% | US$ 11,98M | 2025-12-31 |
| Schroder Investment Management Limited | Institution | 557.620 | 0,50% | US$ 10,68M | 2026-03-31 |
| ICBC Credit Suisse Fund Management Co., Ltd | Institution | 519.970 | 0,46% | US$ 9,96M | 2025-06-30 |
| C WorldWide Asset Management Fondsmaeglerselskab A/S | Institution | 510.000 | 0,45% | US$ 9,77M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 474.580 | 0,42% | US$ 9,09M | 2026-05-29 |
| OrbiMed Advisors LLC | Institution | 468.250 | 0,42% | US$ 8,97M | 2025-09-30 |