| FMR LLC | Institution | 11.781.024 | 13,57% | US$ 1,04B | 2026-03-31 |
| BlackRock, Inc. | Institution | 5.521.145 | 6,36% | US$ 485,25M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 4.319.496 | 4,97% | US$ 379,64M | 2026-04-15 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 4.319.496 | 4,97% | US$ 379,64M | 2026-04-15 |
| RTW Investments, LP | Institution | 4.171.996 | 4,80% | US$ 366,68M | 2026-03-31 |
| Fairmount Funds Management LLC | Institution | 4.018.101 | 4,63% | US$ 353,15M | 2026-04-16 |
| Fairmount Healthcare Fund II L.P. | Institution | 4.018.101 | 4,63% | US$ 353,15M | 2026-04-16 |
| VR Management, LLC | Institution | 3.685.448 | 4,24% | US$ 323,91M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 3.057.401 | 3,52% | US$ 268,71M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 2.790.785 | 3,21% | US$ 245,28M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.607.031 | 3,00% | US$ 229,13M | 2026-03-31 |
| Capital Research and Management Company | Institution | 2.412.693 | 2,78% | US$ 212,05M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 2.328.026 | 2,68% | US$ 204,61M | 2024-09-30 |
| Paradigm Biocapital Advisors LP | Institution | 1.957.266 | 2,25% | US$ 172,02M | 2026-03-31 |
| Commodore Capital LP | Institution | 1.912.380 | 2,20% | US$ 168,08M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 1.900.582 | 2,19% | US$ 167,04M | 2026-03-31 |
| Tang Capital Management, LLC | Institution | 1.892.200 | 2,18% | US$ 166,31M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 1.824.811 | 2,10% | US$ 160,38M | 2026-03-31 |
| Tang Capital Partners, LP | Institution | 1.799.658 | 2,07% | US$ 158,17M | 2025-04-24 |
| Geode Capital Management, LLC | Institution | 1.720.912 | 1,98% | US$ 151,25M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 1.656.164 | 1,91% | US$ 145,56M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 1.621.620 | 1,87% | US$ 142,52M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 1.598.730 | 1,84% | US$ 140,51M | 2026-03-31 |
| Remedium Capital Partners, LLC | Institution | 1.456.231 | 1,68% | US$ 127,99M | 2026-03-31 |
| Tang Capital Partners International, LP | Institution | 1.400.342 | 1,61% | US$ 123,08M | 2025-04-24 |
| Affinity Asset Advisors, LLC | Institution | 1.279.134 | 1,47% | US$ 112,42M | 2026-03-31 |
| Bank of America Corporation | Institution | 1.228.093 | 1,41% | US$ 107,94M | 2026-03-31 |
| Emerald Advisers, LLC | Institution | 1.021.478 | 1,18% | US$ 89,78M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 1.000.000 | 1,15% | US$ 87,89M | 2024-09-30 |
| Baker Bros. Advisors LP | Institution | 1.000.000 | 1,15% | US$ 87,89M | 2026-03-31 |
| Braidwell LP | Institution | 932.823 | 1,07% | US$ 81,99M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 923.881 | 1,06% | US$ 81,20M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 882.778 | 1,02% | US$ 77,59M | 2026-03-31 |
| UBS Asset Management AG | Institution | 878.549 | 1,01% | US$ 77,22M | 2026-03-31 |
| Caligan Partners, LP | Institution | 878.127 | 1,01% | US$ 77,18M | 2026-03-31 |
| Artal Group S.A. | Institution | 818.598 | 0,94% | US$ 71,95M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 792.847 | 0,91% | US$ 69,68M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 610.282 | 0,70% | US$ 53,64M | 2026-03-31 |