| Farallon Capital Management, L.L.C. | Institution | 13.604.796 | 6,40% | US$ 2,55B | 2026-03-31 |
| BlackRock, Inc. | Institution | 11.212.706 | 5,27% | US$ 2,10B | 2026-03-31 |
| Janus Henderson Group plc | Institution | 9.766.496 | 4,59% | US$ 1,83B | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 9.555.357 | 4,49% | US$ 1,79B | 2026-03-31 |
| FMR LLC | Institution | 8.452.363 | 3,98% | US$ 1,58B | 2026-03-31 |
| Farallon Healthcare Partners Master, L.P. | Institution | 8.420.065 | 3,96% | US$ 1,58B | 2025-12-31 |
| Vanguard Capital Management, LLC | Institution | 8.362.284 | 3,93% | US$ 1,57B | 2026-03-31 |
| Nextech Invest Ltd. | Institution | 7.601.087 | 3,58% | US$ 1,43B | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 7.502.623 | 3,53% | US$ 1,41B | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 6.655.703 | 3,13% | US$ 1,25B | 2026-03-31 |
| Wellington Management Group LLP | Institution | 6.027.819 | 2,84% | US$ 1,13B | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 5.475.611 | 2,58% | US$ 1,03B | 2026-03-31 |
| UBS Asset Management AG | Institution | 4.887.386 | 2,30% | US$ 916,43M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 4.402.662 | 2,07% | US$ 825,54M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 3.896.260 | 1,83% | US$ 730,59M | 2026-03-31 |
| Nextech V Oncology S.C.S., SICAV-SIF | Institution | 3.590.313 | 1,69% | US$ 673,22M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 3.338.142 | 1,57% | US$ 625,94M | 2026-03-31 |
| GV Management Company, LLC | Institution | 3.292.525 | 1,55% | US$ 617,38M | 2026-03-31 |
| BVF Partners L.P. | Institution | 2.856.782 | 1,34% | US$ 535,68M | 2026-03-31 |
| Casdin Capital, LLC | Institution | 2.577.333 | 1,21% | US$ 483,28M | 2026-03-31 |
| Woodline Partners LP | Institution | 2.506.570 | 1,18% | US$ 470,01M | 2026-03-31 |
| Farallon Capital Offshore Investors II, L.P | Institution | 2.482.796 | 1,17% | US$ 465,55M | 2025-12-31 |
| Holocene Advisors, LP | Institution | 2.468.644 | 1,16% | US$ 462,90M | 2026-03-31 |
| Norges Bank Investment Management | Institution | 2.455.347 | 1,15% | US$ 460,40M | 2025-12-31 |
| Vestal Point Capital, LP | Institution | 2.375.000 | 1,12% | US$ 445,34M | 2026-03-31 |
| Avoro Capital Advisors LLC | Institution | 2.344.444 | 1,10% | US$ 439,61M | 2026-03-31 |
| Mr. Alexis Borisy | Insider | 2.338.884 | 1,10% | US$ 438,56M | 2026-06-18 |
| Deerfield Management Company, L.P. | Institution | 2.297.000 | 1,08% | US$ 430,71M | 2026-03-31 |
| Darwin Global Management Limited | Institution | 2.211.018 | 1,04% | US$ 414,59M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 2.000.000 | 0,94% | US$ 375,02M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 1.885.821 | 0,89% | US$ 353,61M | 2026-03-31 |
| National Bank Investments Inc. | Institution | 1.749.000 | 0,82% | US$ 327,95M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 1.735.476 | 0,82% | US$ 325,42M | 2026-03-31 |
| Caligan Partners, LP | Institution | 1.652.808 | 0,78% | US$ 309,92M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 1.579.793 | 0,74% | US$ 296,23M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.560.805 | 0,73% | US$ 292,67M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.558.807 | 0,73% | US$ 292,29M | 2026-03-31 |
| Westfield Capital Management Company, L.P. | Institution | 1.556.578 | 0,73% | US$ 291,87M | 2026-03-31 |
| Bellevue Asset Management AG | Institution | 1.544.456 | 0,73% | US$ 289,60M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 1.500.000 | 0,71% | US$ 281,27M | 2026-03-31 |
| Farallon Capital Institutional Partners, L.P. | Institution | 1.377.579 | 0,65% | US$ 258,31M | 2025-12-31 |