| Janus Henderson Group plc | Institution | 16.575.875 | 11,48% | US$ 785,03M | 2026-03-31 |
| FMR LLC | Institution | 16.288.216 | 11,28% | US$ 771,41M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 13.102.446 | 9,07% | US$ 620,53M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 11.474.599 | 7,95% | US$ 543,44M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 11.199.089 | 7,76% | US$ 530,39M | 2026-03-31 |
| BlackRock, Inc. | Institution | 10.971.726 | 7,60% | US$ 519,62M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 6.279.545 | 4,35% | US$ 297,40M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 6.266.701 | 4,34% | US$ 296,79M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 5.614.597 | 3,89% | US$ 265,91M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 4.793.020 | 3,32% | US$ 227,00M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 4.440.519 | 3,08% | US$ 210,30M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 4.300.000 | 2,98% | US$ 203,65M | 2026-03-31 |
| Westfield Capital Management Company, L.P. | Institution | 3.646.138 | 2,53% | US$ 172,68M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 3.201.283 | 2,22% | US$ 151,61M | 2026-03-31 |
| Kynam Capital Management, LP | Institution | 2.922.335 | 2,02% | US$ 138,40M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 2.865.318 | 1,98% | US$ 135,70M | 2026-03-31 |
| Caligan Partners, LP | Institution | 2.060.719 | 1,43% | US$ 97,60M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.747.995 | 1,21% | US$ 82,79M | 2026-03-31 |
| Jennison Associates LLC | Institution | 1.698.011 | 1,18% | US$ 80,42M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 1.425.788 | 0,99% | US$ 67,53M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 1.403.948 | 0,97% | US$ 66,49M | 2026-03-31 |
| Maverick Capital, Ltd. | Institution | 1.377.738 | 0,95% | US$ 65,25M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 1.374.292 | 0,95% | US$ 65,09M | 2026-03-31 |
| Pivotal BioVenture Partners LLC | Institution | 1.372.425 | 0,95% | US$ 65,00M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 1.261.000 | 0,87% | US$ 59,72M | 2026-03-31 |
| Norges Bank Investment Management | Institution | 1.228.939 | 0,85% | US$ 58,20M | 2025-12-31 |
| Bellevue Asset Management AG | Institution | 1.190.697 | 0,82% | US$ 56,39M | 2026-03-31 |
| Assenagon Asset Management S.A. | Institution | 1.164.813 | 0,81% | US$ 55,17M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.144.469 | 0,79% | US$ 54,20M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 978.969 | 0,68% | US$ 46,36M | 2026-03-31 |