| The B Group, Inc. | Institution | 11.414.285 | 6,58% | US$ 20,55M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 10.689.452 | 6,16% | US$ 19,24M | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 10.276.317 | 5,92% | US$ 18,50M | 2026-03-31 |
| Octagon Investments Master Fund LP | Institution | 9.567.898 | 5,51% | US$ 17,22M | 2025-12-31 |
| Soleus Capital Master Fund, L.P. | Institution | 9.353.687 | 5,39% | US$ 16,84M | 2026-05-26 |
| Soleus Capital Management, L.P. | Institution | 9.353.687 | 5,39% | US$ 16,84M | 2026-05-26 |
| Commodore Capital Master LP | Institution | 9.332.443 | 5,38% | US$ 16,80M | 2025-10-01 |
| Perceptive Advisors LLC | Institution | 8.928.149 | 5,14% | US$ 16,07M | 2026-03-31 |
| Janus Henderson Biotech Innovation Master Fund Limited | Institution | 8.897.507 | 5,13% | US$ 16,02M | 2025-11-28 |
| Columbia Management Investment Advisers, LLC | Institution | 8.711.385 | 5,02% | US$ 15,68M | 2026-03-31 |
| Commodore Capital LP | Institution | 7.181.062 | 4,14% | US$ 12,93M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 7.124.116 | 4,10% | US$ 12,82M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 7.124.116 | 4,10% | US$ 12,82M | 2025-12-31 |
| Franklin Resources, Inc. | Institution | 5.785.189 | 3,33% | US$ 10,41M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 5.373.951 | 3,10% | US$ 9,67M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 4.987.499 | 2,87% | US$ 8,98M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 4.799.875 | 2,77% | US$ 8,64M | 2026-03-31 |
| Morgan Stanley | Institution | 4.551.533 | 2,62% | US$ 8,19M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 4.500.000 | 2,59% | US$ 8,10M | 2026-03-31 |
| Squadron Master Fund LP | Institution | 4.500.000 | 2,59% | US$ 8,10M | 2025-12-31 |
| Great Point Partners, LLC | Institution | 3.405.757 | 1,96% | US$ 6,13M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 3.270.845 | 1,88% | US$ 5,89M | 2026-03-31 |
| Federated Hermes, Inc. | Institution | 3.136.607 | 1,81% | US$ 5,65M | 2026-03-31 |
| Squadron Capital Management Llc | Institution | 3.000.000 | 1,73% | US$ 5,40M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 2.904.911 | 1,67% | US$ 5,23M | 2026-03-31 |
| Marshall Wace LLP | Institution | 2.754.403 | 1,59% | US$ 4,96M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 2.500.000 | 1,44% | US$ 4,50M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 2.333.000 | 1,34% | US$ 4,20M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 2.264.845 | 1,30% | US$ 4,08M | 2026-03-31 |
| Millennium Management LLC | Institution | 2.103.353 | 1,21% | US$ 3,79M | 2026-03-31 |
| HighVista Strategies LLC | Institution | 2.019.326 | 1,16% | US$ 3,63M | 2026-03-31 |
| Artia Global Partners LP | Institution | 1.992.367 | 1,15% | US$ 3,59M | 2026-03-31 |
| BlackRock, Inc. | Institution | 1.876.340 | 1,08% | US$ 3,38M | 2026-03-31 |
| Sphera Funds Management Ltd | Institution | 1.733.471 | 1,00% | US$ 3,12M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.546.240 | 0,89% | US$ 2,78M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.454.400 | 0,84% | US$ 2,62M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.429.308 | 0,82% | US$ 2,57M | 2026-03-31 |
| L1 Group Limited | Institution | 1.231.414 | 0,71% | US$ 2,22M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.166.951 | 0,67% | US$ 2,10M | 2026-03-31 |
| Propel Bio Management, LLC | Institution | 765.000 | 0,44% | US$ 1,38M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 662.900 | 0,38% | US$ 1,19M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 659.289 | 0,38% | US$ 1,19M | 2026-03-31 |