| Ecor1 Capital Fund Qualified, L.P. | Institution | 75.173.532 | 47,10% | US$ 23,75M | 2026-03-31 |
| Janus Henderson Biotech Innovation Master Fund Limited | Institution | 20.126.582 | 12,61% | US$ 6,36M | 2025-03-31 |
| Rubric Capital Management LP | Institution | 15.307.347 | 9,59% | US$ 4,84M | 2026-03-31 |
| EcoR1 Capital, LLC | Institution | 13.368.855 | 8,38% | US$ 4,22M | 2026-03-31 |
| 683 Capital Partners, LP | Institution | 13.016.763 | 8,15% | US$ 4,11M | 2026-01-06 |
| 683 Capital Management, LLC | Institution | 12.000.000 | 7,52% | US$ 3,79M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 10.893.766 | 6,82% | US$ 3,44M | 2024-12-31 |
| Defilade Capital Management, L.P. | Institution | 7.558.756 | 4,74% | US$ 2,39M | 2026-03-31 |
| Newtyn Management, LLC | Institution | 7.079.056 | 4,43% | US$ 2,24M | 2026-03-31 |
| Millennium Management LLC | Institution | 3.559.103 | 2,23% | US$ 1,12M | 2026-03-31 |
| Tejara Capital Limited | Institution | 2.037.520 | 1,28% | US$ 643,86k | 2026-03-31 |
| Frazier Life Sciences Public Overage Fund, L.P. | Institution | 1.501.856 | 0,94% | US$ 474,59k | 2025-04-01 |
| UBS Asset Management AG | Institution | 1.490.128 | 0,93% | US$ 470,88k | 2026-03-31 |
| Wealthspire Advisors LLC | Institution | 796.036 | 0,50% | US$ 251,55k | 2026-03-31 |
| Marshall Wace LLP | Institution | 686.987 | 0,43% | US$ 217,09k | 2026-03-31 |
| Group One Trading LLC | Institution | 335.827 | 0,21% | US$ 106,12k | 2026-03-31 |
| Rangeley Capital, LLC | Institution | 329.200 | 0,21% | US$ 104,03k | 2026-03-31 |
| BlackRock, Inc. | Institution | 302.991 | 0,19% | US$ 95,75k | 2026-03-31 |
| Knott Partners Management, LLC | Institution | 300.337 | 0,19% | US$ 94,91k | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 209.084 | 0,13% | US$ 66,07k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 195.920 | 0,12% | US$ 61,91k | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 187.839 | 0,12% | US$ 59,36k | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 150.000 | 0,09% | US$ 47,40k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 139.973 | 0,09% | US$ 44,23k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 133.379 | 0,08% | US$ 42,15k | 2026-03-31 |
| Forefront Analytics, LLC | Institution | 127.778 | 0,08% | US$ 40,38k | 2026-03-31 |
| Virtus Investment Advisers, LLC | Institution | 125.662 | 0,08% | US$ 39,71k | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 92.534 | 0,06% | US$ 29,24k | 2026-03-31 |
| Arctic Asset Management AS | Institution | 88.190 | 0,06% | US$ 27,87k | 2025-06-30 |
| XTX Markets Limited | Institution | 84.469 | 0,05% | US$ 26,69k | 2026-03-31 |
| Caption Management, LLC | Institution | 64.064 | 0,04% | US$ 20,24k | 2026-03-31 |
| SmartHarvest Portfolios LLC | Institution | 49.512 | 0,03% | US$ 15,65k | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 48.400 | 0,03% | US$ 15,29k | 2026-03-31 |
| Sterne Agee Asset Management, Inc. | Institution | 36.873 | 0,02% | US$ 11,65k | 2026-03-31 |
| Virtu Financial, Inc. | Institution | 36.458 | 0,02% | US$ 11,52k | 2026-03-31 |
| Independent Advisor Alliance, LLC | Institution | 35.227 | 0,02% | US$ 11,13k | 2026-03-31 |
| Clear Harbor Asset Management, LLC | Institution | 35.000 | 0,02% | US$ 11,06k | 2026-03-31 |
| Significant Wealth Partners LLC | Institution | 25.634 | 0,02% | US$ 8,10k | 2026-03-31 |
| Centiva Capital, LP | Institution | 25.000 | 0,02% | US$ 7,90k | 2026-03-31 |
| Engineers Gate Manager LP | Institution | 23.954 | 0,02% | US$ 7,57k | 2026-03-31 |
| JPMorgan Chase & Co. | Institution | 21.848 | 0,01% | US$ 6,90k | 2026-03-31 |
| Rhumbline Advisers Ltd Partnership | Institution | 19.572 | 0,01% | US$ 6,18k | 2026-03-31 |
| GAMMA Investing LLC | Institution | 19.274 | 0,01% | US$ 6,09k | 2026-03-31 |
| Three Magnolias Financial Advisors, LLC | Institution | 19.000 | 0,01% | US$ 6,00k | 2026-03-31 |
| NFSG Corporation | Institution | 18.750 | 0,01% | US$ 5,93k | 2026-03-31 |
| OneDigital Investment Advisors, LLC | Institution | 18.300 | 0,01% | US$ 5,78k | 2026-03-31 |