| Baker Bros. Advisors LP | Institution | 2.141.701 | 9,29% | US$ 969,89M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 2.018.647 | 8,76% | US$ 914,16M | 2026-03-31 |
| RTW Investments, LP | Institution | 1.993.687 | 8,65% | US$ 902,86M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 1.944.143 | 8,43% | US$ 880,42M | 2025-08-20 |
| Avoro Capital Advisors LLC | Institution | 1.818.181 | 7,89% | US$ 823,38M | 2026-03-31 |
| BlackRock, Inc. | Institution | 1.559.942 | 6,77% | US$ 706,44M | 2026-03-31 |
| Paulson & Co. Inc. | Institution | 1.392.188 | 6,04% | US$ 630,47M | 2026-03-31 |
| Dr. Paul Friedman | Insider | 953.995 | 4,14% | US$ 432,03M | 2026-01-09 |
| Vanguard Portfolio Management, LLC | Institution | 841.145 | 3,65% | US$ 380,92M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 827.144 | 3,59% | US$ 374,58M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 694.958 | 3,01% | US$ 314,72M | 2026-03-31 |
| SQN, LLC | Institution | 655.540 | 2,84% | US$ 296,87M | 2026-03-06 |
| State Street Global Advisors, Inc. | Institution | 609.525 | 2,64% | US$ 276,03M | 2026-03-31 |
| FMR LLC | Institution | 511.622 | 2,22% | US$ 231,69M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 455.870 | 1,98% | US$ 206,45M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 453.843 | 1,97% | US$ 205,53M | 2026-03-31 |
| Dr. Rebecca Taub | Insider | 441.033 | 1,91% | US$ 199,73M | 2026-03-06 |
| Dr. Frederick Craves | Insider | 368.004 | 1,60% | US$ 166,65M | 2025-04-01 |
| William Blair Investment Management, LLC | Institution | 354.222 | 1,54% | US$ 160,41M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 328.110 | 1,42% | US$ 148,59M | 2026-03-31 |
| Invesco Ltd. | Institution | 311.732 | 1,35% | US$ 141,17M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 289.310 | 1,25% | US$ 131,02M | 2026-03-31 |
| Armistice Capital LLC | Institution | 264.583 | 1,15% | US$ 119,82M | 2026-03-31 |
| Hood River Capital Management LLC | Institution | 249.511 | 1,08% | US$ 112,99M | 2026-03-31 |
| Lord, Abbett & Co. LLC | Institution | 242.726 | 1,05% | US$ 109,92M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 225.510 | 0,98% | US$ 102,12M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 216.720 | 0,94% | US$ 98,14M | 2026-03-31 |
| 667, L.P. | Institution | 198.988 | 0,86% | US$ 90,11M | 2025-08-20 |
| Norges Bank Investment Management | Institution | 196.393 | 0,85% | US$ 88,94M | 2025-12-31 |
| Pictet Asset Management Limited | Institution | 187.240 | 0,81% | US$ 84,79M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 185.331 | 0,80% | US$ 83,93M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 183.540 | 0,80% | US$ 83,12M | 2026-03-31 |
| Fiera Capital Corporation | Institution | 174.011 | 0,75% | US$ 78,80M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 170.999 | 0,74% | US$ 77,44M | 2026-03-31 |
| American Century Investment Management Inc | Institution | 163.933 | 0,71% | US$ 74,24M | 2026-03-31 |
| Erste Asset Management GmbH | Institution | 160.210 | 0,69% | US$ 72,55M | 2026-03-31 |
| Morgan Stanley | Institution | 159.303 | 0,69% | US$ 72,14M | 2026-03-31 |