| Baker Bros. Advisors LP | Institution | 2.141.701 | 9,29% | US$ 1,10B | 2026-03-31 |
| Janus Henderson Group plc | Institution | 2.018.647 | 8,76% | US$ 1,04B | 2026-03-31 |
| RTW Investments, LP | Institution | 1.993.687 | 8,65% | US$ 1,02B | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 1.944.143 | 8,43% | US$ 998,88M | 2025-08-20 |
| Avoro Capital Advisors LLC | Institution | 1.818.181 | 7,89% | US$ 934,16M | 2026-03-31 |
| Paulson & Co. Inc. | Institution | 1.392.188 | 6,04% | US$ 715,29M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 694.958 | 3,01% | US$ 357,06M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 453.843 | 1,97% | US$ 233,18M | 2026-03-31 |
| William Blair Investment Management, LLC | Institution | 354.222 | 1,54% | US$ 182,00M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 328.110 | 1,42% | US$ 168,58M | 2026-03-31 |
| Invesco Ltd. | Institution | 311.732 | 1,35% | US$ 160,16M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 289.310 | 1,25% | US$ 148,64M | 2026-03-31 |
| Armistice Capital LLC | Institution | 264.583 | 1,15% | US$ 135,94M | 2026-03-31 |
| Hood River Capital Management LLC | Institution | 249.511 | 1,08% | US$ 128,20M | 2026-03-31 |
| Lord, Abbett & Co. LLC | Institution | 242.726 | 1,05% | US$ 124,71M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 225.510 | 0,98% | US$ 115,86M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 216.720 | 0,94% | US$ 111,35M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 187.240 | 0,81% | US$ 96,20M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 185.331 | 0,80% | US$ 95,22M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 183.540 | 0,80% | US$ 94,30M | 2026-03-31 |
| Fiera Capital Corporation | Institution | 174.011 | 0,75% | US$ 89,41M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 170.999 | 0,74% | US$ 87,86M | 2026-03-31 |
| American Century Investment Management Inc | Institution | 163.933 | 0,71% | US$ 84,23M | 2026-03-31 |
| Erste Asset Management GmbH | Institution | 160.210 | 0,69% | US$ 82,31M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 153.741 | 0,67% | US$ 78,99M | 2026-03-31 |
| UBS Asset Management AG | Institution | 141.575 | 0,61% | US$ 72,74M | 2026-03-31 |
| The Toronto-Dominion Bank | Institution | 130.460 | 0,57% | US$ 67,03M | 2026-03-31 |
| Woodline Partners LP | Institution | 125.899 | 0,55% | US$ 64,69M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 110.960 | 0,48% | US$ 57,01M | 2026-03-31 |