| Deerfield Management Company, L.P. | Institution | 35.606.974 | 34,11% | US$ 129,25M | 2026-03-31 |
| Deerfield Private Design Fund IV, L.P. | Institution | 10.622.957 | 10,18% | US$ 38,56M | 2026-02-27 |
| Deerfield Private Design Fund III, L.P. | Institution | 10.622.928 | 10,18% | US$ 38,56M | 2026-02-27 |
| Deerfield Healthcare Innovations Fund, L.P. | Institution | 8.153.107 | 7,81% | US$ 29,60M | 2026-02-27 |
| CHI Advisors LLC | Institution | 7.120.007 | 6,82% | US$ 25,85M | 2026-03-31 |
| Deerfield Partners, LP | Institution | 6.207.982 | 5,95% | US$ 22,53M | 2026-02-27 |
| Opaleye L.P | Institution | 4.110.000 | 3,94% | US$ 14,92M | 2025-08-29 |
| BlackRock, Inc. | Institution | 3.752.200 | 3,59% | US$ 13,62M | 2026-03-31 |
| Millennium Management LLC | Institution | 3.625.278 | 3,47% | US$ 13,16M | 2026-03-31 |
| Janus Henderson Biotech Innovation Master Fund Limited | Institution | 3.356.076 | 3,22% | US$ 12,18M | 2025-03-31 |
| Aigh Capital Management, LLC | Institution | 3.000.000 | 2,87% | US$ 10,89M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 2.934.399 | 2,81% | US$ 10,65M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.866.349 | 2,75% | US$ 10,40M | 2026-03-31 |
| Dafna Capital Management, LLC | Institution | 2.029.164 | 1,94% | US$ 7,37M | 2026-03-31 |
| RTW Investments, LP | Institution | 1.500.000 | 1,44% | US$ 5,45M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 1.500.000 | 1,44% | US$ 5,45M | 2026-03-31 |
| Woodline Partners LP | Institution | 1.400.850 | 1,34% | US$ 5,09M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.108.761 | 1,06% | US$ 4,02M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 1.066.960 | 1,02% | US$ 3,87M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 1.047.385 | 1,00% | US$ 3,80M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.015.892 | 0,97% | US$ 3,69M | 2026-03-31 |
| Marshall Wace LLP | Institution | 933.464 | 0,89% | US$ 3,39M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 911.326 | 0,87% | US$ 3,31M | 2026-03-31 |
| Gem Investment Advisors, LLC | Institution | 854.230 | 0,82% | US$ 3,10M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 847.644 | 0,81% | US$ 3,08M | 2026-03-31 |
| Mr. Thomas Hamilton | Insider | 824.231 | 0,79% | US$ 2,99M | 2026-04-03 |
| Dimensional Fund Advisors LP | Institution | 798.462 | 0,76% | US$ 2,90M | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 792.982 | 0,76% | US$ 2,88M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 739.942 | 0,71% | US$ 2,69M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 664.342 | 0,64% | US$ 2,41M | 2026-03-31 |
| Caption Management, LLC | Institution | 635.024 | 0,61% | US$ 2,31M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 617.211 | 0,59% | US$ 2,24M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 575.624 | 0,55% | US$ 2,09M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 554.007 | 0,53% | US$ 2,01M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 545.693 | 0,52% | US$ 1,98M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 519.132 | 0,50% | US$ 1,88M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 475.612 | 0,46% | US$ 1,73M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 406.558 | 0,39% | US$ 1,48M | 2026-03-31 |
| Crestline Investors Inc. | Institution | 379.765 | 0,36% | US$ 1,38M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 376.503 | 0,36% | US$ 1,37M | 2026-03-31 |
| Morgan Stanley | Institution | 348.390 | 0,33% | US$ 1,26M | 2026-03-31 |