| 2026-05-28 | Ms. Neena M. PatilExec. VP & Chief Legal Officer | -1,19k | 282,47k | Automatic Disposition | 236,97 | 18,85k | -5,95% |
| 2026-05-28 | Ms. Samantha PearceExec. VP & Chief Commercial Officer | -6,91k | 870,01k | Derivative Exercise and Sale | 109,45 - 235,41 | 17,01k | - |
| 2026-05-28 | Mr. Seamus C. MulliganIndependent Director | 3,42k | 471,54k | Derivative Exercise and Retained Stock | 138,08 | 1,28M | 0,27% |
| 2026-05-22 | Mr. Rick E. WinninghamLead Independent Director | -2,74k | 283,67k | Derivative Exercise and Sale | 138,08 - 241,57 | 6,06k | - |
| 2026-05-22 | Mr. Rick E. WinninghamLead Independent Director | 674,00 | 93,07k | Derivative Exercise and Retained Stock | 138,08 | 6,06k | 12,51% |
| 2026-05-22 | Ms. Heather Ann McSharryIndependent Director | -2,00k | 482,00k | Verkauf | 241,00 | 14,94k | -11,80% |
| 2026-05-01 | Mr. Bruce C. CozaddCo-Founder & Chairman | -6,00k | 1,22M | Verkauf | 203,33 | 340,49k | -1,73% |
| 2026-04-01 | Mr. Bruce C. CozaddCo-Founder & Chairman | -6,00k | 1,14M | Automatic Disposition | 190,22 - 191,74 | 346,49k | -1,70% |
| 2026-03-05 | Mr. Bruce C. CozaddCo-Founder & Chairman | -15,11k | 2,85M | Sale to Issuer | 188,69 | 341,89k | -4,23% |
| 2026-03-05 | Mr. Philip L. JohnsonExec. VP & CFO | -2,62k | 493,42k | Sale to Issuer | 188,69 | 20,53k | -11,30% |
| 2026-03-05 | Ms. Mary Elizabeth HendersonSVP of Technical Operations | -1,39k | 260,33k | Sale to Issuer | 186,75 | 7,02k | -16,57% |
| 2026-03-05 | Ms. Samantha PearceExec. VP & Chief Commercial Officer | -2,50k | 472,29k | Sale to Issuer | 188,69 | 17,01k | -12,83% |
| 2026-03-05 | Dr. Robert IannoneExec. VP, Chief Medical Officer and Global Head of Research & Development | -6,21k | 1,17M | Sale to Issuer | 188,69 | 40,33k | -13,34% |
| 2026-03-09 | Ms. Patricia CarrSenior VP & CAO | -1,29k | 235,44k | Verkauf | 182,94 | 0,00 | -100,00% |
| 2026-03-05 | Ms. Patricia CarrSenior VP & CAO | -1,44k | 268,21k | Sale to Issuer | 186,77 | 0,00 | -100,00% |
| 2026-03-05 | Ms. Renee D. GalaPresident, CEO & Director | -7,07k | 1,33M | Sale to Issuer | 188,69 | 46,93k | -13,08% |
| 2026-03-05 | Ms. Neena M. PatilExec. VP & Chief Legal Officer | -5,00k | 943,45k | Sale to Issuer | 188,69 | 20,04k | -19,96% |
| 2026-03-03 | Mr. Bruce C. CozaddCo-Founder & Chairman | -6,00k | 1,12M | Verkauf | 186,09 - 187,84 | 324,24k | -1,82% |
| 2026-02-27 | Dr. Norbert G. RiedelIndependent Director | -3,42k | 184,14k | Derivative Exercise and Sale | 138,08 - 192,00 | 14,15k | - |
| 2026-02-27 | Ms. Patricia CarrSenior VP & CAO | -1,12k | 213,24k | Verkauf | 190,91 | 0,00 | -100,00% |
| 2026-02-26 | Ms. Patricia CarrSenior VP & CAO | -1,25k | 243,22k | Verkauf | 194,11 | 0,00 | -100,00% |
| 2026-02-26 | Ms. Neena M. PatilExec. VP & Chief Legal Officer | 47,21k | 5,99M | Derivative Exercise and Retained Stock | 113,10 - 137,12 | 14,25k | -143,24% |
| 2026-02-26 | Ms. Neena M. PatilExec. VP & Chief Legal Officer | -3,79k | 222,74k | Derivative Exercise and Sale | 113,10 - 192,07 | 14,25k | - |
| 2026-02-26 | Ms. Neena M. PatilExec. VP & Chief Legal Officer | -51,81k | 9,93M | Verkauf | 190,00 - 193,60 | 14,25k | -78,43% |
| 2026-02-26 | Ms. Mary Elizabeth HendersonSVP of Technical Operations | -5,34k | 1,04M | Verkauf | 194,49 | 5,77k | -48,07% |
| 2026-01-16 | Ms. Neena M. PatilExec. VP & Chief Legal Officer | -3,28k | 560,55k | Sale to Issuer | 171,16 | 18,85k | -14,80% |
| 2026-01-16 | Ms. Samantha PearceExec. VP & Chief Commercial Officer | -1,60k | 273,68k | Sale to Issuer | 171,16 | 13,33k | -10,71% |
| 2026-01-16 | Dr. Robert IannoneExec. VP, Chief Medical Officer and Global Head of Research & Development | -4,14k | 708,60k | Sale to Issuer | 171,16 | 31,92k | -11,48% |
| 2026-01-16 | Ms. Renee D. GalaPresident, CEO & Director | -5,37k | 919,30k | Sale to Issuer | 171,16 | 37,11k | -12,64% |
| 2026-01-16 | Mr. Bruce C. CozaddCo-Founder & Chairman | -17,45k | 2,99M | Sale to Issuer | 171,16 | 308,45k | -5,36% |
| 2025-08-18 | Mr. Patrick Gerald EnrightIndependent Director | -5,00k | 0,00 | Other Disposition | - | 17,87k | -21,86% |
| 2025-12-09 | Ms. Mary Elizabeth HendersonSVP of Technical Operations | -2,24k | 379,37k | Verkauf | 169,51 | 999,00 | -69,14% |
| 2025-12-05 | Ms. Renee D. GalaPresident, CEO & Director | -80,00 | 13,35k | Sale to Issuer | 166,91 | 29,74k | -0,27% |
| 2025-12-05 | Ms. Patricia CarrSenior VP & CAO | -4,50k | 137,39k | Derivative Exercise and Sale | 140,67 - 171,20 | 0,00 | - |
| 2025-12-05 | Ms. Patricia CarrSenior VP & CAO | -160,00 | 27,38k | Verkauf | 171,11 | 0,00 | -100,00% |
| 2025-12-02 | Mr. Kenneth William O’KeefeInsider | -603,00 | 104,36k | Sale to Issuer | 173,07 | 26,75k | -2,20% |
| 2025-11-26 | Mr. Bruce C. CozaddCo-Founder & Chairman | -77,50k | 4,22M | Derivative Exercise and Sale | 123,36 - 179,79 | 289,98k | - |
| 2025-11-20 | Ms. Heather Ann McSharryIndependent Director | -3,42k | 135,58k | Derivative Exercise and Sale | 138,08 - 177,78 | 16,94k | - |
| 2025-11-19 | Ms. Mary Elizabeth HendersonSVP of Technical Operations | -1,33k | 240,11k | Sale to Issuer | 180,40 | 3,24k | -29,14% |
| 2025-11-18 | Mr. Bruce C. CozaddCo-Founder & Chairman | -17,28k | 3,13M | Verkauf | 180,09 - 181,81 | 289,98k | -5,62% |
| 2025-11-18 | Mr. Bruce C. CozaddCo-Founder & Chairman | -717,00 | 130,92k | Verkauf | 182,60 | 289,98k | -0,25% |
| 2025-11-18 | Ms. Patricia CarrSenior VP & CAO | -5,25k | 240,92k | Derivative Exercise and Sale | 136,18 - 182,07 | 621,00 | - |
| 2025-11-18 | Ms. Patricia CarrSenior VP & CAO | -69,00 | 12,53k | Verkauf | 181,66 | 621,00 | -10,00% |
| 2025-11-18 | Mr. Rick E. WinninghamLead Independent Director | -5,50k | 994,73k | Verkauf | 180,86 | 5,39k | -50,52% |
| 2025-11-17 | Dr. Robert IannoneExec. VP, Chief Medical Officer and Global Head of Research & Development | -7,16k | 1,20M | Automatic Disposition | 168,26 | 24,29k | -22,77% |
| 2025-10-01 | Mr. Bruce C. CozaddCo-Founder & Chairman | -5,50k | 753,56k | Automatic Disposition | 131,78 - 140,00 | 307,98k | -1,75% |
| 2025-09-14 | Mr. Bruce C. CozaddCo-Founder & Chairman | -15,65k | 1,97M | Sale to Issuer | 126,16 | 313,48k | -4,75% |
| 2025-09-02 | Mr. Bruce C. CozaddCo-Founder & Chairman | -6,00k | 771,69k | Automatic Disposition | 127,23 - 130,00 | 329,13k | -1,79% |
| 2025-08-08 | Mr. Kenneth William O’KeefeInsider | -1,81k | 200,81k | Sale to Issuer | 111,25 | 29,61k | -5,75% |
| 2025-08-08 | Ms. Jennifer E. CookIndependent Non-Executive Director | -1,81k | 200,81k | Sale to Issuer | 111,25 | 7,33k | -19,76% |
| 2025-08-08 | Mr. Patrick Gerald EnrightIndependent Director | -1,81k | 200,80k | Sale to Issuer | 111,25 | 22,87k | -7,31% |
| 2025-08-08 | Ms. Laura Jean HamillIndependent Director | -1,81k | 200,81k | Sale to Issuer | 111,25 | 3,43k | -34,51% |
| 2025-08-08 | Mr. Patrick T. KennedyIndependent Director | -1,96k | 217,94k | Sale to Issuer | 111,25 | 3,20k | -38,01% |
| 2025-08-08 | Ms. Heather Ann McSharryIndependent Director | -1,96k | 217,94k | Sale to Issuer | 111,25 | 16,94k | -10,36% |
| 2025-08-08 | Ms. Anne O'RiordanIndependent Director | -1,81k | 200,81k | Sale to Issuer | 111,25 | 12,99k | -12,20% |
| 2025-08-08 | Dr. Norbert G. RiedelIndependent Director | -1,81k | 200,81k | Sale to Issuer | 111,25 | 14,15k | -11,32% |
| 2025-08-08 | Dr. Mark Douglas SmithIndependent Non-Executive Director | -1,81k | 200,81k | Sale to Issuer | 111,25 | 7,33k | -19,76% |
| 2025-08-08 | Mr. Rick E. WinninghamLead Independent Director | -1,81k | 200,81k | Sale to Issuer | 111,25 | 10,89k | -14,22% |
| 2025-08-05 | Ms. Samantha PearceExec. VP & Chief Commercial Officer | -577,00 | 66,99k | Sale to Issuer | 116,10 | 11,16k | -4,92% |
| 2025-08-01 | Mr. Bruce C. CozaddCo-Founder & Chairman | -1.000,00 | 113,21k | Automatic Disposition | 113,21 | 335,13k | -0,30% |
| 2025-07-01 | Mr. Bruce C. CozaddCo-Founder & Chairman | -1.000,00 | 107,63k | Automatic Disposition | 105,26 - 110,00 | 336,13k | -0,30% |
| 2025-06-02 | Mr. Bruce C. CozaddCo-Founder & Chairman | -1.000,00 | 108,95k | Automatic Disposition | 107,90 - 110,00 | 337,13k | -0,30% |