| JPMorgan Chase & Co. | Institution | 21.028.373 | 10,12% | US$ 73,60M | 2026-05-18 |
| Invus Public Equities, L.P. | Institution | 15.945.067 | 7,68% | US$ 55,81M | 2025-11-13 |
| Artal Group S.A. | Institution | 15.945.067 | 7,68% | US$ 55,81M | 2025-11-13 |
| Andera Partners | Institution | 14.114.476 | 6,80% | US$ 49,40M | 2026-03-31 |
| Biodiscovery 6 FPCI | Institution | 14.114.476 | 6,80% | US$ 49,40M | 2025-12-31 |
| Samsara BioCapital LLC | Institution | 13.540.194 | 6,52% | US$ 47,39M | 2026-03-31 |
| Sofinnova Crossover I | Institution | 12.332.804 | 5,94% | US$ 43,16M | 2025-12-31 |
| Eventide Asset Management, LLC | Institution | 9.368.517 | 4,51% | US$ 32,79M | 2026-03-31 |
| Eventide Healthcare Innovation Fund I LP | Institution | 9.368.517 | 4,51% | US$ 32,79M | 2025-12-31 |
| BVF Partners L.P. | Institution | 8.545.499 | 4,11% | US$ 29,91M | 2026-03-31 |
| Sofinnova Partners SAS | Institution | 8.433.227 | 4,06% | US$ 29,52M | 2026-06-02 |
| Samsara Biocapital, L.P. | Institution | 8.345.389 | 4,02% | US$ 29,21M | 2025-11-17 |
| Deep Track Capital, LP | Institution | 7.800.465 | 3,76% | US$ 27,30M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 7.800.465 | 3,76% | US$ 27,30M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 6.945.995 | 3,34% | US$ 24,31M | 2025-09-30 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 6.945.995 | 3,34% | US$ 24,31M | 2025-09-30 |
| Sofinnova Crossover Ii S.L.P. | Institution | 6.753.246 | 3,25% | US$ 23,64M | 2025-12-31 |
| New Enterprise Associates, Inc. | Institution | 6.684.064 | 3,22% | US$ 23,39M | 2026-03-31 |
| New Enterprise Associates 17, L.P. | Institution | 6.684.064 | 3,22% | US$ 23,39M | 2026-03-30 |
| Mr. Frederic Cren | Insider | 5.878.991 | 2,83% | US$ 20,58M | 2026-03-04 |
| Samsara Opportunity Fund, L.P. | Institution | 5.194.805 | 2,50% | US$ 18,18M | 2025-11-17 |
| Qatar Holding LLC | Institution | 5.157.233 | 2,48% | US$ 18,05M | 2025-07-22 |
| Caligan Partners, LP | Institution | 4.974.906 | 2,40% | US$ 17,41M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 4.632.138 | 2,23% | US$ 16,21M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 4.630.461 | 2,23% | US$ 16,21M | 2025-11-17 |
| Paradigm Biocapital Advisors LP | Institution | 4.000.000 | 1,93% | US$ 14,00M | 2026-03-31 |
| Biomedical Value Fund | Institution | 3.658.944 | 1,76% | US$ 12,81M | 2025-09-30 |
| Great Point Partners, LLC | Institution | 3.449.937 | 1,66% | US$ 12,07M | 2025-12-31 |
| Dr. Pierre Broqua | Insider | 3.428.070 | 1,65% | US$ 12,00M | 2026-03-04 |
| Biotechnology Value Fund II, L.P. | Institution | 3.321.861 | 1,60% | US$ 11,63M | 2025-11-17 |
| Millennium Management LLC | Institution | 2.987.613 | 1,44% | US$ 10,46M | 2026-03-31 |
| Trails Edge Capital Partners, LP | Institution | 2.657.997 | 1,28% | US$ 9,30M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 2.461.565 | 1,19% | US$ 8,62M | 2026-03-31 |
| Symbiosis Capital Partners, LLC | Institution | 2.354.000 | 1,13% | US$ 8,24M | 2026-03-31 |
| UBS Asset Management AG | Institution | 2.318.693 | 1,12% | US$ 8,12M | 2026-03-31 |
| Ally Bridge Group | Institution | 2.245.300 | 1,08% | US$ 7,86M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 2.174.398 | 1,05% | US$ 7,61M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.932.160 | 0,93% | US$ 6,76M | 2026-03-31 |
| NEA 18 Venture Growth Equity, L.P. | Institution | 1.666.666 | 0,80% | US$ 5,83M | 2026-03-30 |
| Biomedical Offshore Value Fund, LTD. | Institution | 1.643.874 | 0,79% | US$ 5,75M | 2025-09-30 |
| Boothbay Fund Management, LLC | Institution | 1.470.407 | 0,71% | US$ 5,15M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 1.429.101 | 0,69% | US$ 5,00M | 2026-03-31 |
| Inventiva S.A. Esop | Institution | 1.338.127 | 0,64% | US$ 4,68M | 2024-10-15 |
| Nextbio Capital Management Lp | Institution | 1.333.484 | 0,64% | US$ 4,67M | 2026-03-31 |
| RTW Investments, LP | Institution | 1.298.702 | 0,63% | US$ 4,55M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 960.865 | 0,46% | US$ 3,36M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 956.221 | 0,46% | US$ 3,35M | 2026-03-31 |