| 2026-05-11 | Mr. Daniel G. KirbyChief Commercial Officer | -2,44k | 9,01k | Derivative Exercise and Sale | 3,70 | 146,95k | - |
| 2026-05-11 | Mr. Daniel G. KirbyChief Commercial Officer | 7,57k | 0,00 | Derivative Exercise and Retained Stock | - | 146,95k | 5,43% |
| 2026-03-05 | Dr. Friedrich Graf FinckensteinChief Medical Officer | 14,73k | 0,00 | Derivative Exercise and Retained Stock | - | 131,96k | 12,56% |
| 2026-03-05 | Dr. Friedrich Graf FinckensteinChief Medical Officer | -16,52k | 75,66k | Derivative Exercise and Sale | 4,58 | 131,96k | - |
| 2026-03-05 | Dr. Frederick G. VogtInterim CEO, President, General Counsel, Corporate Secretary & Director | 35,74k | 0,00 | Derivative Exercise and Retained Stock | - | 529,54k | 7,24% |
| 2026-03-05 | Dr. Frederick G. VogtInterim CEO, President, General Counsel, Corporate Secretary & Director | -26,76k | 122,54k | Derivative Exercise and Sale | 4,58 | 529,54k | - |
| 2026-03-05 | Dr. Raj K. PuriChief Regulatory Officer | 20,70k | 0,00 | Derivative Exercise and Retained Stock | - | 239,23k | 9,47% |
| 2026-03-05 | Dr. Raj K. PuriChief Regulatory Officer | -18,36k | 84,09k | Derivative Exercise and Sale | 4,58 | 239,23k | - |
| 2026-03-05 | Dr. Igor P. BilinskyCOO | 14,62k | 0,00 | Derivative Exercise and Retained Stock | - | 125,77k | 13,15% |
| 2026-03-05 | Dr. Igor P. BilinskyCOO | -16,63k | 76,16k | Derivative Exercise and Sale | 4,58 | 125,77k | - |
| 2026-03-02 | Dr. Frederick G. VogtInterim CEO, President, General Counsel, Corporate Secretary & Director | 29,28k | 0,00 | Derivative Exercise and Retained Stock | - | 493,80k | 6,30% |
| 2026-03-02 | Dr. Frederick G. VogtInterim CEO, President, General Counsel, Corporate Secretary & Director | -22,81k | 86,45k | Derivative Exercise and Sale | 3,79 | 493,80k | - |
| 2026-03-02 | Dr. Raj K. PuriChief Regulatory Officer | 2,67k | 0,00 | Derivative Exercise and Retained Stock | - | 218,53k | 1,24% |
| 2026-03-02 | Dr. Raj K. PuriChief Regulatory Officer | -2,80k | 10,60k | Derivative Exercise and Sale | 3,79 | 218,53k | - |
| 2026-03-02 | Dr. Igor P. BilinskyCOO | 5,40k | 0,00 | Derivative Exercise and Retained Stock | - | 111,15k | 5,11% |
| 2026-03-02 | Dr. Igor P. BilinskyCOO | -6,90k | 26,16k | Derivative Exercise and Sale | 3,79 | 111,15k | - |
| 2026-03-02 | Dr. Friedrich Graf FinckensteinChief Medical Officer | 5,58k | 0,00 | Derivative Exercise and Retained Stock | - | 117,23k | 4,99% |
| 2026-03-02 | Dr. Friedrich Graf FinckensteinChief Medical Officer | -7,12k | 26,99k | Derivative Exercise and Sale | 3,79 | 117,23k | - |
| 2026-02-24 | Mr. Daniel G. KirbyChief Commercial Officer | 85,84k | 0,00 | Derivative Exercise and Retained Stock | - | 139,38k | 160,30% |
| 2026-02-24 | Mr. Daniel G. KirbyChief Commercial Officer | -34,17k | 129,14k | Derivative Exercise and Sale | 3,78 | 139,38k | - |
| 2026-02-10 | Mr. Daniel G. KirbyChief Commercial Officer | 23,55k | 0,00 | Derivative Exercise and Retained Stock | - | 53,55k | 78,49% |
| 2026-02-10 | Mr. Daniel G. KirbyChief Commercial Officer | -16,45k | 42,77k | Derivative Exercise and Sale | 2,60 | 53,55k | - |
| 2025-12-01 | Dr. Friedrich Graf FinckensteinChief Medical Officer | 6,25k | 0,00 | Derivative Exercise and Retained Stock | - | 111,66k | 5,93% |
| 2025-12-01 | Dr. Friedrich Graf FinckensteinChief Medical Officer | -6,45k | 14,20k | Derivative Exercise and Sale | 2,14 - 2,23 | 111,66k | - |
| 2025-12-01 | Dr. Igor P. BilinskyCOO | 6,06k | 0,00 | Derivative Exercise and Retained Stock | - | 105,74k | 6,07% |
| 2025-12-01 | Dr. Igor P. BilinskyCOO | -6,25k | 13,78k | Derivative Exercise and Sale | 2,14 - 2,23 | 105,74k | - |
| 2025-12-01 | Dr. Frederick G. VogtInterim CEO, President, General Counsel, Corporate Secretary & Director | 29,96k | 0,00 | Derivative Exercise and Retained Stock | - | 464,52k | 6,89% |
| 2025-12-01 | Dr. Frederick G. VogtInterim CEO, President, General Counsel, Corporate Secretary & Director | -22,13k | 48,94k | Derivative Exercise and Sale | 2,14 - 2,23 | 464,52k | - |
| 2025-12-01 | Dr. Raj K. PuriChief Regulatory Officer | 3,00k | 0,00 | Derivative Exercise and Retained Stock | - | 215,86k | 1,41% |
| 2025-12-01 | Dr. Raj K. PuriChief Regulatory Officer | -2,47k | 5,50k | Derivative Exercise and Sale | 2,23 | 215,86k | - |
| 2025-09-02 | Dr. Frederick G. VogtInterim CEO, President, General Counsel, Corporate Secretary & Director | 29,96k | 0,00 | Derivative Exercise and Retained Stock | - | 434,56k | 7,40% |
| 2025-09-02 | Dr. Frederick G. VogtInterim CEO, President, General Counsel, Corporate Secretary & Director | -22,13k | 48,46k | Derivative Exercise and Sale | 2,19 | 434,56k | - |
| 2025-09-02 | Dr. Raj K. PuriChief Regulatory Officer | 3,00k | 0,00 | Derivative Exercise and Retained Stock | - | 212,86k | 1,43% |
| 2025-09-02 | Dr. Raj K. PuriChief Regulatory Officer | -2,47k | 5,40k | Derivative Exercise and Sale | 2,19 | 212,86k | - |
| 2025-09-02 | Dr. Igor P. BilinskyCOO | 6,06k | 0,00 | Derivative Exercise and Retained Stock | - | 99,69k | 6,47% |
| 2025-09-02 | Dr. Igor P. BilinskyCOO | -6,25k | 13,69k | Derivative Exercise and Sale | 2,19 | 99,69k | - |
| 2025-09-02 | Dr. Friedrich Graf FinckensteinChief Medical Officer | 6,25k | 0,00 | Derivative Exercise and Retained Stock | - | 105,41k | 6,30% |
| 2025-09-02 | Dr. Friedrich Graf FinckensteinChief Medical Officer | -6,45k | 14,12k | Derivative Exercise and Sale | 2,19 | 105,41k | - |
| 2025-06-05 | Mr. Daniel G. KirbyChief Commercial Officer | 30,00k | 55,20k | Kauf | 1,84 | 30,00k | - |
| 2025-06-02 | Dr. Raj K. PuriChief Regulatory Officer | 3,00k | 0,00 | Derivative Exercise and Retained Stock | - | 209,85k | 1,45% |
| 2025-06-02 | Dr. Raj K. PuriChief Regulatory Officer | -2,47k | 4,34k | Derivative Exercise and Sale | 1,76 | 209,85k | - |
| 2025-06-02 | Dr. Frederick G. VogtInterim CEO, President, General Counsel, Corporate Secretary & Director | 29,96k | 0,00 | Derivative Exercise and Retained Stock | - | 404,60k | 8,00% |
| 2025-06-02 | Dr. Frederick G. VogtInterim CEO, President, General Counsel, Corporate Secretary & Director | -22,13k | 38,94k | Derivative Exercise and Sale | 1,76 | 404,60k | - |
| 2025-06-02 | Dr. Friedrich Graf FinckensteinChief Medical Officer | 6,25k | 0,00 | Derivative Exercise and Retained Stock | - | 99,16k | 6,72% |
| 2025-06-02 | Dr. Friedrich Graf FinckensteinChief Medical Officer | -6,45k | 11,35k | Derivative Exercise and Sale | 1,76 | 99,16k | - |
| 2025-06-02 | Dr. Igor P. BilinskyCOO | 6,06k | 0,00 | Derivative Exercise and Retained Stock | - | 93,63k | 6,91% |
| 2025-06-02 | Dr. Igor P. BilinskyCOO | -6,25k | 11,00k | Derivative Exercise and Sale | 1,76 | 93,63k | - |
| 2025-06-02 | Mr. Jean-Marc BelleminInsider | 4,33k | 0,00 | Derivative Exercise and Retained Stock | - | 60,53k | 7,70% |
| 2025-06-02 | Mr. Jean-Marc BelleminInsider | -4,46k | 7,86k | Derivative Exercise and Sale | 1,76 | 60,53k | - |