| BlackRock, Inc. | Institution | 31.080.505 | 6,96% | US$ 117,48M | 2026-03-31 |
| MHR Fund Management LLC | Institution | 28.967.103 | 6,49% | US$ 109,50M | 2026-03-31 |
| Mr. Wayne Rothbaum | Insider | 28.067.333 | 6,29% | US$ 106,09M | 2026-04-15 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 22.112.266 | 4,95% | US$ 83,58M | 2024-12-31 |
| State Street Global Advisors, Inc. | Institution | 17.448.108 | 3,91% | US$ 65,95M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 16.617.737 | 3,72% | US$ 62,82M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 13.687.433 | 3,07% | US$ 51,74M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 11.700.844 | 2,62% | US$ 44,23M | 2026-03-31 |
| Millennium Management LLC | Institution | 9.414.292 | 2,11% | US$ 35,59M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 8.572.598 | 1,92% | US$ 32,40M | 2026-03-31 |
| Invenomic Capital Management LP | Institution | 8.495.551 | 1,90% | US$ 32,11M | 2026-03-31 |
| Bank of America Corporation | Institution | 8.490.119 | 1,90% | US$ 32,09M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 8.016.353 | 1,80% | US$ 30,30M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 7.934.511 | 1,78% | US$ 29,99M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 6.349.563 | 1,42% | US$ 24,00M | 2026-03-31 |
| Morgan Stanley | Institution | 5.671.180 | 1,27% | US$ 21,44M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 4.173.886 | 0,93% | US$ 15,78M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 3.911.192 | 0,88% | US$ 14,78M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 3.568.014 | 0,80% | US$ 13,49M | 2026-03-31 |
| Hudson River Trading LLC | Institution | 3.486.299 | 0,78% | US$ 13,18M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 3.166.861 | 0,71% | US$ 11,97M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 2.875.526 | 0,64% | US$ 10,87M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 2.783.730 | 0,62% | US$ 10,52M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 2.645.702 | 0,59% | US$ 10,00M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 2.611.345 | 0,58% | US$ 9,87M | 2026-03-31 |
| UBS Asset Management AG | Institution | 2.390.803 | 0,54% | US$ 9,04M | 2026-03-31 |
| Marshall Wace LLP | Institution | 2.355.612 | 0,53% | US$ 8,90M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 2.249.766 | 0,50% | US$ 8,50M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 2.184.298 | 0,49% | US$ 8,26M | 2026-03-31 |
| Long Focus Capital Management LLC | Institution | 2.100.000 | 0,47% | US$ 7,94M | 2026-03-31 |
| Wells Fargo & Company | Institution | 2.071.524 | 0,46% | US$ 7,83M | 2026-03-31 |
| Orion Investment Co | Institution | 2.065.652 | 0,46% | US$ 7,81M | 2026-03-31 |
| Rhenman & Partners Asset Management AB | Institution | 2.055.327 | 0,46% | US$ 7,77M | 2026-03-31 |
| Knott Partners Management, LLC | Institution | 1.600.000 | 0,36% | US$ 6,05M | 2026-03-31 |