| MHR Fund Management LLC | Institution | 28.967.103 | 6,49% | US$ 115,00M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 22.112.266 | 4,95% | US$ 87,79M | 2024-12-31 |
| Two Sigma Investments, LP | Institution | 13.687.433 | 3,07% | US$ 54,34M | 2026-03-31 |
| Millennium Management LLC | Institution | 9.414.292 | 2,11% | US$ 37,37M | 2026-03-31 |
| Invenomic Capital Management LP | Institution | 8.495.551 | 1,90% | US$ 33,73M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 8.016.353 | 1,80% | US$ 31,82M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 6.349.563 | 1,42% | US$ 25,21M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 4.173.886 | 0,93% | US$ 16,57M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 3.911.192 | 0,88% | US$ 15,53M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 3.568.014 | 0,80% | US$ 14,17M | 2026-03-31 |
| Hudson River Trading LLC | Institution | 3.486.299 | 0,78% | US$ 13,84M | 2026-03-31 |
| Long Focus Capital Management LLC | Institution | 2.100.000 | 0,47% | US$ 8,34M | 2026-03-31 |
| Orion Investment Co | Institution | 2.065.652 | 0,46% | US$ 8,20M | 2026-03-31 |
| Rhenman & Partners Asset Management AB | Institution | 2.055.327 | 0,46% | US$ 8,16M | 2026-03-31 |
| Knott Partners Management, LLC | Institution | 1.600.000 | 0,36% | US$ 6,35M | 2026-03-31 |
| Rice Hall James & Associates, LLC | Institution | 1.514.907 | 0,34% | US$ 6,01M | 2026-03-31 |
| The B Group, Inc. | Institution | 1.500.000 | 0,34% | US$ 5,96M | 2026-03-31 |
| C WorldWide Asset Management Fondsmaeglerselskab A/S | Institution | 1.260.000 | 0,28% | US$ 5,00M | 2026-03-31 |
| Mirador Capital Partners, LP | Institution | 1.073.236 | 0,24% | US$ 4,26M | 2026-03-31 |
| Voloridge Investment Management, LLC | Institution | 1.022.780 | 0,23% | US$ 4,06M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 1.000.000 | 0,22% | US$ 3,97M | 2026-03-31 |
| Sector Gamma AS | Institution | 900.000 | 0,20% | US$ 3,57M | 2026-03-31 |
| QVT Financial LP | Institution | 678.564 | 0,15% | US$ 2,69M | 2026-03-31 |