| JP Morgan Asset Management | Institution | 19.990.249 | 9,22% | US$ 2,36B | 2026-03-31 |
| Darwin Global Management Limited | Institution | 16.805.184 | 7,75% | US$ 1,99B | 2026-03-31 |
| BlackRock, Inc. | Institution | 16.678.146 | 7,69% | US$ 1,97B | 2026-03-31 |
| Darwin Global Master Fund, Ltd. | Institution | 14.182.375 | 6,54% | US$ 1,68B | 2026-03-31 |
| FMR LLC | Institution | 13.019.170 | 6,01% | US$ 1,54B | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 10.371.802 | 4,79% | US$ 1,23B | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 7.421.111 | 3,42% | US$ 877,62M | 2026-03-31 |
| Capital Research and Management Company | Institution | 6.957.485 | 3,21% | US$ 822,79M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 6.527.301 | 3,01% | US$ 771,92M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 5.625.825 | 2,60% | US$ 665,31M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 5.551.699 | 2,56% | US$ 656,54M | 2026-03-31 |
| RTW Investments, LP | Institution | 4.842.880 | 2,23% | US$ 572,72M | 2026-03-31 |
| JPMorgan Chase & Co. | Institution | 4.153.415 | 1,92% | US$ 491,18M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 3.092.807 | 1,43% | US$ 365,76M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 3.057.718 | 1,41% | US$ 361,61M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 2.288.995 | 1,06% | US$ 270,70M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 2.182.571 | 1,01% | US$ 258,11M | 2026-03-31 |
| Orbis Investment Management Limited | Institution | 1.872.824 | 0,86% | US$ 221,48M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 1.500.000 | 0,69% | US$ 177,39M | 2026-03-31 |
| Westfield Capital Management Company, L.P. | Institution | 1.468.459 | 0,68% | US$ 173,66M | 2026-03-31 |
| SEI Investments Company | Institution | 1.395.794 | 0,64% | US$ 165,07M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.294.000 | 0,60% | US$ 153,03M | 2026-03-31 |
| Castle Hook Partners LP | Institution | 1.269.754 | 0,59% | US$ 150,16M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 1.254.488 | 0,58% | US$ 148,36M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.157.786 | 0,53% | US$ 136,92M | 2026-03-31 |
| Duquesne Family Office LLC | Institution | 1.154.090 | 0,53% | US$ 136,48M | 2026-03-31 |
| Nomura Investment Management Business Trust | Institution | 1.143.739 | 0,53% | US$ 135,26M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 1.102.248 | 0,51% | US$ 130,35M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 1.069.390 | 0,49% | US$ 126,47M | 2026-03-31 |
| Managed Account Advisors LLC | Institution | 1.022.212 | 0,47% | US$ 120,89M | 2026-03-31 |
| Fiera Capital Corporation | Institution | 1.021.970 | 0,47% | US$ 120,86M | 2026-03-31 |
| NWI Management LP | Institution | 1.014.000 | 0,47% | US$ 119,92M | 2026-03-31 |
| William Blair Investment Management, LLC | Institution | 958.910 | 0,44% | US$ 113,40M | 2026-03-31 |