| Baker Bros. Advisors LP | Institution | 4.028.614 | 9,39% | US$ 282,57M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 3.253.684 | 7,58% | US$ 228,21M | 2026-03-31 |
| BlackRock, Inc. | Institution | 2.968.536 | 6,92% | US$ 208,21M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.891.893 | 4,41% | US$ 132,70M | 2026-03-31 |
| Farallon Healthcare Partners Master, L.P. | Institution | 1.864.419 | 4,34% | US$ 130,77M | 2026-03-31 |
| PRIMECAP Management Company | Institution | 1.843.772 | 4,30% | US$ 129,32M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 1.722.797 | 4,01% | US$ 120,84M | 2026-03-31 |
| Sessa Capital IM, L.P. | Institution | 1.719.314 | 4,01% | US$ 120,59M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.527.105 | 3,56% | US$ 107,11M | 2026-03-31 |
| Sessa Capital (Master), L.P. | Institution | 1.508.077 | 3,51% | US$ 105,78M | 2025-04-30 |
| Illumina, Inc. | Institution | 1.302.126 | 3,03% | US$ 91,33M | 2026-02-17 |
| Arbiter Partners Capital Management, LLC | Institution | 1.034.597 | 2,41% | US$ 72,57M | 2026-03-31 |
| Morgan Stanley | Institution | 991.187 | 2,31% | US$ 69,52M | 2026-03-31 |
| Bank of America Corporation | Institution | 910.065 | 2,12% | US$ 63,83M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 827.942 | 1,93% | US$ 58,07M | 2026-03-31 |
| Jefferies Financial Group Inc. | Institution | 657.500 | 1,53% | US$ 46,12M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 645.456 | 1,50% | US$ 45,27M | 2026-03-31 |
| Farallon Capital Offshore Investors II, L.P | Institution | 595.840 | 1,39% | US$ 41,79M | 2026-03-31 |
| Morgan Stanley Investment Management Inc. | Institution | 573.985 | 1,34% | US$ 40,26M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 510.425 | 1,19% | US$ 35,80M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 428.266 | 1,00% | US$ 30,04M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 408.650 | 0,95% | US$ 28,66M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 349.137 | 0,81% | US$ 24,49M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 334.906 | 0,78% | US$ 23,49M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 317.228 | 0,74% | US$ 22,25M | 2026-03-31 |
| Mr. Robert Ragusa | Insider | 308.989 | 0,72% | US$ 21,67M | 2026-04-22 |
| Citigroup Inc. | Institution | 302.136 | 0,70% | US$ 21,19M | 2026-03-31 |
| Raymond James Financial, Inc. | Institution | 292.138 | 0,68% | US$ 20,49M | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 287.619 | 0,67% | US$ 20,17M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 269.953 | 0,63% | US$ 18,93M | 2026-03-31 |
| Farallon Capital Institutional Partners, L.P. | Institution | 267.221 | 0,62% | US$ 18,74M | 2026-03-31 |
| Farallon Capital Partners, L.P. | Institution | 249.315 | 0,58% | US$ 17,49M | 2026-03-31 |
| UBS Asset Management AG | Institution | 242.376 | 0,56% | US$ 17,00M | 2026-03-31 |
| Casdin Capital, LLC | Institution | 230.000 | 0,54% | US$ 16,13M | 2026-03-31 |
| Slow Capital, Inc. | Institution | 228.256 | 0,53% | US$ 16,01M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 217.428 | 0,51% | US$ 15,25M | 2026-03-31 |
| Carnegie Capital Asset Management, LLC | Institution | 217.100 | 0,51% | US$ 15,23M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 201.229 | 0,47% | US$ 14,11M | 2026-03-31 |
| Natixis S.A. | Institution | 199.368 | 0,46% | US$ 13,98M | 2026-03-31 |
| TCW Group, Inc. | Institution | 191.313 | 0,45% | US$ 13,42M | 2026-03-31 |