| Manchester Management Company, LLC | Institution | 3.830.869 | 5,86% | US$ 24,56M | 2026-03-31 |
| Manchester Explorer, L.P. | Institution | 3.707.942 | 5,68% | US$ 23,77M | 2026-03-31 |
| Beutel Goodman & Company Ltd. | Institution | 3.666.465 | 5,61% | US$ 23,50M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 1.589.005 | 2,43% | US$ 10,19M | 2026-03-31 |
| Vivo Capital, LLC | Institution | 1.350.000 | 2,07% | US$ 8,65M | 2026-03-31 |
| Scotiabank Global Banking and Markets, Asset Management Division | Institution | 1.342.178 | 2,05% | US$ 8,60M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 1.214.741 | 1,86% | US$ 7,79M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 1.200.000 | 1,84% | US$ 7,69M | 2026-03-31 |
| Seven Fleet Capital Management LP | Institution | 709.515 | 1,09% | US$ 4,55M | 2026-03-31 |
| Redmile Group, LLC | Institution | 700.000 | 1,07% | US$ 4,49M | 2026-03-31 |
| Rubric Capital Management LP | Institution | 691.170 | 1,06% | US$ 4,43M | 2026-03-31 |
| Squadron Capital Management Llc | Institution | 680.000 | 1,04% | US$ 4,36M | 2026-03-31 |
| Ally Bridge Group | Institution | 660.375 | 1,01% | US$ 4,23M | 2026-03-31 |
| PFM Health Sciences, LP | Institution | 540.871 | 0,83% | US$ 3,47M | 2026-03-31 |
| Matco Financial, Inc. | Institution | 467.000 | 0,71% | US$ 2,99M | 2025-12-31 |
| Velan Capital Partners LP | Institution | 352.000 | 0,54% | US$ 2,26M | 2026-03-31 |
| Crestline Investors Inc. | Institution | 327.997 | 0,50% | US$ 2,10M | 2026-03-31 |
| Aisling Capital Management LP | Institution | 325.000 | 0,50% | US$ 2,08M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 323.843 | 0,50% | US$ 2,08M | 2026-03-31 |
| Dv Trading, LLC | Institution | 276.000 | 0,42% | US$ 1,77M | 2026-03-31 |
| Ingalls & Snyder, LLC | Institution | 75.650 | 0,12% | US$ 484,92k | 2026-03-31 |
| Diadema Partners LP | Institution | 40.000 | 0,06% | US$ 256,40k | 2026-03-31 |
| Persistent Asset Partners Limited | Institution | 37.926 | 0,06% | US$ 243,11k | 2026-03-31 |
| Faircourt Asset Management, Inc. | Institution | 21.400 | 0,03% | US$ 137,17k | 2025-12-31 |
| AXQ Capital, LP | Institution | 15.760 | 0,02% | US$ 101,02k | 2026-03-31 |
| Guardian Wealth Advisors, LLC | Institution | 10.500 | 0,02% | US$ 67,31k | 2026-03-31 |