| Sirenia Capital Management LP | Institution | 1.200.000 | 13,50% | US$ 8,26M | 2026-03-31 |
| Dr. Pardeep Nijhawan | Insider | 1.004.923 | 11,31% | US$ 6,91M | 2026-06-01 |
| Velan Capital Partners LP | Institution | 827.500 | 9,31% | US$ 5,69M | 2026-03-31 |
| Rubric Capital Management LP | Institution | 687.500 | 7,74% | US$ 4,73M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 600.000 | 6,75% | US$ 4,13M | 2026-03-02 |
| Perceptive Advisors LLC | Institution | 563.239 | 6,34% | US$ 3,88M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 563.239 | 6,34% | US$ 3,88M | 2026-03-09 |
| Dr. Michael Brooks | Insider | 126.550 | 1,42% | US$ 870,66k | 2026-05-27 |
| Jane Street Group, LLC | Institution | 115.721 | 1,30% | US$ 796,16k | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 85.966 | 0,97% | US$ 591,45k | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 77.054 | 0,87% | US$ 530,13k | 2026-03-31 |
| 1968160 Ontario Inc. | Institution | 53.104 | 0,60% | US$ 365,36k | 2026-06-01 |
| Mr. Patrick Marshall | Insider | 42.131 | 0,47% | US$ 289,86k | 2026-05-27 |
| Vanguard Fiduciary Trust Company | Institution | 38.446 | 0,43% | US$ 264,51k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 37.979 | 0,43% | US$ 261,30k | 2026-03-31 |
| Commonwealth Equity Services, LLC | Institution | 35.003 | 0,39% | US$ 240,82k | 2026-03-31 |
| The Digestive Health Clinic Inc. | Institution | 32.013 | 0,36% | US$ 220,25k | 2026-06-01 |
| Scientech Research LLC | Institution | 30.534 | 0,34% | US$ 210,07k | 2026-03-31 |
| Stonepine Capital Management LLC | Institution | 30.000 | 0,34% | US$ 206,40k | 2026-03-31 |
| Stonepine Capital, L.P. | Institution | 30.000 | 0,34% | US$ 206,40k | 2026-03-31 |
| BlackRock, Inc. | Institution | 27.709 | 0,31% | US$ 190,64k | 2026-03-31 |
| Virtu Financial, Inc. | Institution | 26.275 | 0,30% | US$ 180,77k | 2026-03-31 |
| Schonfeld Strategic Advisors LLC | Institution | 19.650 | 0,22% | US$ 135,19k | 2026-03-31 |
| Scotiabank Global Banking and Markets, Asset Management Division | Institution | 15.843 | 0,18% | US$ 109,00k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 14.994 | 0,17% | US$ 103,16k | 2026-03-31 |
| Mr. Carlo Sistilli | Insider | 10.938 | 0,12% | US$ 75,25k | 2026-05-27 |
| SBI Holdings, Inc. | Institution | 3.502 | 0,04% | US$ 24,09k | 2026-03-31 |
| UBS Asset Management AG | Institution | 2.343 | 0,03% | US$ 16,12k | 2026-03-31 |
| Mr. Sean MacDonald | Insider | 2.053 | 0,02% | US$ 14,12k | 2026-05-27 |
| RBC Dominion Securities Inc. | Institution | 1.659 | 0,02% | US$ 11,41k | 2026-03-31 |
| McGuire Capital Management, L.L.C. | Institution | 1.500 | 0,02% | US$ 10,32k | 2026-03-31 |
| FMR LLC | Institution | 1.334 | 0,02% | US$ 9,18k | 2026-03-31 |
| Tower Research Capital Europe Limited | Institution | 507 | 0,01% | US$ 3,49k | 2026-03-31 |
| Citigroup Inc. | Institution | 487 | 0,01% | US$ 3,35k | 2026-03-31 |
| Vanguard Global Advisers, LLC | Institution | 162 | 0,00% | US$ 1,11k | 2026-03-31 |
| Global Retirement Partners, LLC | Institution | 86 | 0,00% | US$ 591,68 | 2025-12-31 |
| Ms. Joan Chypyha | Insider | 29 | 0,00% | US$ 199,52 | 2026-05-27 |
| BCV Asset Management | Institution | 3 | 0,00% | US$ 20,64 | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 2 | 0,00% | US$ 13,76 | 2026-03-31 |
| AllSquare Wealth Management, LLC | Institution | 1 | 0,00% | US$ 6,88 | 2025-09-30 |
| Danske Capital AS (Estonia) | Institution | 1 | 0,00% | US$ 6,88 | 2026-03-31 |
| Dogwood Wealth Management, LLC | Institution | 1 | 0,00% | US$ 6,88 | 2026-03-31 |
| LRI Investments, LLC | Institution | 1 | 0,00% | US$ 6,88 | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 0 | 0,00% | - | 2026-03-31 |