| BlackRock, Inc. | Institution | 13.033.975 | 8,21% | US$ 338,62M | 2026-03-31 |
| Baillie Gifford & Co. | Institution | 12.066.479 | 7,60% | US$ 313,49M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 10.983.338 | 6,92% | US$ 285,35M | 2026-03-31 |
| Temasek Holdings (Private) Limited | Institution | 7.012.974 | 4,42% | US$ 182,20M | 2026-03-31 |
| UBS Asset Management AG | Institution | 7.003.658 | 4,41% | US$ 181,96M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 6.272.001 | 3,95% | US$ 162,95M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 6.147.957 | 3,87% | US$ 159,72M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 6.120.160 | 3,86% | US$ 159,00M | 2026-03-31 |
| Norges Bank Investment Management | Institution | 5.119.622 | 3,23% | US$ 133,01M | 2025-12-31 |
| FMR LLC | Institution | 4.560.585 | 2,87% | US$ 118,48M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 3.727.114 | 2,35% | US$ 96,83M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 3.405.393 | 2,15% | US$ 88,47M | 2026-06-03 |
| Baker Bros. Advisors LP | Institution | 3.405.393 | 2,15% | US$ 88,47M | 2026-06-03 |
| Holocene Advisors, LP | Institution | 3.195.429 | 2,01% | US$ 83,02M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 2.893.618 | 1,82% | US$ 75,18M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 2.724.340 | 1,72% | US$ 70,78M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 2.692.175 | 1,70% | US$ 69,94M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 2.558.865 | 1,61% | US$ 66,48M | 2026-03-31 |
| Capital Research and Management Company | Institution | 2.514.588 | 1,58% | US$ 65,33M | 2026-03-31 |
| Fisher Asset Management, LLC | Institution | 2.436.895 | 1,54% | US$ 63,31M | 2026-03-31 |
| Crestline Investors Inc. | Institution | 2.210.732 | 1,39% | US$ 57,43M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 1.941.123 | 1,22% | US$ 50,43M | 2026-03-31 |
| Lynx1 Capital Management LP | Institution | 1.880.303 | 1,18% | US$ 48,85M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 1.871.455 | 1,18% | US$ 48,62M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 1.854.446 | 1,17% | US$ 48,18M | 2026-03-31 |
| Casdin Capital, LLC | Institution | 1.840.000 | 1,16% | US$ 47,80M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 1.773.326 | 1,12% | US$ 46,07M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.682.915 | 1,06% | US$ 43,72M | 2026-03-31 |
| Principal Global Investors, LLC | Institution | 1.478.486 | 0,93% | US$ 38,41M | 2026-03-31 |
| Artal Group S.A. | Institution | 1.396.513 | 0,88% | US$ 36,28M | 2026-03-31 |
| Defilade Capital Management, L.P. | Institution | 1.359.969 | 0,86% | US$ 35,33M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.310.656 | 0,83% | US$ 34,05M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.257.950 | 0,79% | US$ 32,68M | 2026-03-31 |
| Foresite Capital Management, LLC | Institution | 1.209.971 | 0,76% | US$ 31,44M | 2026-03-31 |