| T. Rowe Price Group, Inc. | Institution | 10.373.369 | 11,76% | US$ 718,46M | 2026-03-31 |
| RTW Investments, LP | Institution | 6.984.808 | 7,92% | US$ 483,77M | 2026-03-31 |
| Decheng Capital LLC | Institution | 6.371.669 | 7,22% | US$ 441,30M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 5.371.232 | 6,09% | US$ 372,01M | 2026-03-31 |
| BlackRock, Inc. | Institution | 5.064.180 | 5,74% | US$ 350,75M | 2026-03-31 |
| Longitude Capital Management Co., LLC | Institution | 4.662.268 | 5,29% | US$ 322,91M | 2026-03-01 |
| Decheng Capital Global Life Sciences Fund IV, L.P. | Institution | 4.558.812 | 5,17% | US$ 315,74M | 2024-12-16 |
| FMR LLC | Institution | 3.764.843 | 4,27% | US$ 260,75M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 3.670.206 | 4,16% | US$ 254,20M | 2026-03-31 |
| ORI Capital | Institution | 3.490.913 | 3,96% | US$ 241,78M | 2025-09-03 |
| Foresite Capital Management, LLC | Institution | 3.225.524 | 3,66% | US$ 223,40M | 2026-03-31 |
| Longitude Venture Partners IV, L.P. | Institution | 3.190.463 | 3,62% | US$ 220,97M | 2026-03-01 |
| Vanguard Portfolio Management, LLC | Institution | 3.095.098 | 3,51% | US$ 214,37M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 3.033.625 | 3,44% | US$ 210,11M | 2026-03-31 |
| ORI Healthcare Fund II L.P. | Institution | 2.903.931 | 3,29% | US$ 201,13M | 2025-09-03 |
| State Street Global Advisors, Inc. | Institution | 2.647.054 | 3,00% | US$ 183,33M | 2026-03-31 |
| UBS Asset Management AG | Institution | 2.376.944 | 2,69% | US$ 164,63M | 2026-03-31 |
| Seven Fleet Partners Lp | Institution | 1.886.236 | 2,14% | US$ 130,64M | 2026-06-25 |
| Seven Fleet Capital Management LP | Institution | 1.886.236 | 2,14% | US$ 130,64M | 2026-06-25 |
| Geode Capital Management, LLC | Institution | 1.596.864 | 1,81% | US$ 110,60M | 2026-03-31 |
| Longitude Prime Fund, L.P. | Institution | 1.471.805 | 1,67% | US$ 101,94M | 2026-03-01 |
| Dv Trading, LLC | Institution | 1.439.393 | 1,63% | US$ 99,69M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 1.290.087 | 1,46% | US$ 89,35M | 2026-03-31 |
| Avidity Partners Management, L.P. | Institution | 1.288.948 | 1,46% | US$ 89,27M | 2026-03-31 |
| Bank of America Corporation | Institution | 1.264.892 | 1,43% | US$ 87,61M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 1.163.892 | 1,32% | US$ 80,61M | 2026-03-31 |
| Acorn Bioventures | Institution | 1.130.501 | 1,28% | US$ 78,30M | 2026-03-31 |
| EcoR1 Capital, LLC | Institution | 1.102.000 | 1,25% | US$ 76,32M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 999.623 | 1,13% | US$ 69,23M | 2026-03-31 |
| Braidwell LP | Institution | 984.783 | 1,12% | US$ 68,21M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 948.267 | 1,08% | US$ 65,68M | 2026-03-31 |
| ClearBridge Investments, LLC | Institution | 730.283 | 0,83% | US$ 50,58M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 704.461 | 0,80% | US$ 48,79M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 674.000 | 0,76% | US$ 46,68M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 671.828 | 0,76% | US$ 46,53M | 2026-03-31 |