| FMR LLC | Institution | 3.188.401 | 6,07% | US$ 49,10M | 2026-05-29 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 3.055.027 | 5,81% | US$ 47,05M | 2026-05-29 |
| Deep Track Capital, LP | Institution | 3.055.027 | 5,81% | US$ 47,05M | 2026-05-29 |
| TCG Crossover Management, LLC | Institution | 3.017.120 | 5,74% | US$ 46,46M | 2026-05-05 |
| TCG Crossover Fund II, L.P. | Institution | 3.017.120 | 5,74% | US$ 46,46M | 2026-05-05 |
| Point72 Asset Management, L.P. | Institution | 2.710.817 | 5,16% | US$ 41,75M | 2026-05-22 |
| Point72 Associates, LLC | Institution | 2.710.817 | 5,16% | US$ 41,75M | 2026-05-22 |
| BVF Partners L.P. | Institution | 2.677.385 | 5,09% | US$ 41,23M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 2.162.684 | 4,11% | US$ 33,31M | 2026-03-31 |
| Caligan Partners, LP | Institution | 1.635.023 | 3,11% | US$ 25,18M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 1.447.651 | 2,75% | US$ 22,29M | 2026-03-31 |
| Avoro Life Sciences Fund LLC | Institution | 1.410.000 | 2,68% | US$ 21,71M | 2026-03-31 |
| Avoro Capital Advisors LLC | Institution | 1.410.000 | 2,68% | US$ 21,71M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 1.340.840 | 2,55% | US$ 20,65M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 1.235.000 | 2,35% | US$ 19,02M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.141.980 | 2,17% | US$ 17,59M | 2026-03-31 |
| Affinity Healthcare Fund, LP | Institution | 1.051.054 | 2,00% | US$ 16,19M | 2026-01-22 |
| Biotechnology Value Fund II, L.P. | Institution | 1.035.952 | 1,97% | US$ 15,95M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 916.000 | 1,74% | US$ 14,11M | 2026-03-31 |
| RTW Investments, LP | Institution | 856.962 | 1,63% | US$ 13,20M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 854.000 | 1,62% | US$ 13,15M | 2026-03-31 |
| Millennium Management LLC | Institution | 835.484 | 1,59% | US$ 12,87M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 731.586 | 1,39% | US$ 11,27M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 719.694 | 1,37% | US$ 11,08M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 675.000 | 1,28% | US$ 10,40M | 2026-03-31 |
| Logos Global Master Fund, LP | Institution | 675.000 | 1,28% | US$ 10,40M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 662.968 | 1,26% | US$ 10,21M | 2026-03-31 |
| Bank of America Corporation | Institution | 643.000 | 1,22% | US$ 9,90M | 2026-03-31 |
| Seven Fleet Capital Management LP | Institution | 573.883 | 1,09% | US$ 8,84M | 2026-03-31 |
| Mr. Patrick Crutcher | Insider | 549.467 | 1,05% | US$ 8,46M | 2025-08-06 |
| Commodore Capital LP | Institution | 483.000 | 0,92% | US$ 7,44M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 475.165 | 0,90% | US$ 7,32M | 2026-03-31 |
| Jennison Associates LLC | Institution | 470.775 | 0,90% | US$ 7,25M | 2026-03-31 |
| Caption Management, LLC | Institution | 455.000 | 0,87% | US$ 7,01M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 441.978 | 0,84% | US$ 6,81M | 2026-03-31 |
| Atlas Diversified Master Fund, Ltd. | Institution | 439.312 | 0,84% | US$ 6,77M | 2025-12-31 |
| BNP Paribas Financial Markets SNC | Institution | 422.781 | 0,80% | US$ 6,51M | 2026-03-31 |
| Kennedy Capital Management LLC | Institution | 387.982 | 0,74% | US$ 5,97M | 2026-03-31 |
| Dv Trading, LLC | Institution | 360.064 | 0,68% | US$ 5,54M | 2026-03-31 |
| BlackRock, Inc. | Institution | 327.082 | 0,62% | US$ 5,04M | 2026-03-31 |
| Norges Bank Investment Management | Institution | 326.909 | 0,62% | US$ 5,03M | 2025-12-31 |
| Boothbay Fund Management, LLC | Institution | 324.258 | 0,62% | US$ 4,99M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 304.163 | 0,58% | US$ 4,68M | 2026-04-30 |
| Boxer Capital Management, LLC | Institution | 300.000 | 0,57% | US$ 4,62M | 2026-03-31 |