| FMR LLC | Institution | 3.188.401 | 6,07% | US$ 63,64M | 2026-05-29 |
| Deep Track Capital, LP | Institution | 3.055.027 | 5,81% | US$ 60,98M | 2026-05-29 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 3.055.027 | 5,81% | US$ 60,98M | 2026-05-29 |
| TCG Crossover Fund II, L.P. | Institution | 3.017.120 | 5,74% | US$ 60,22M | 2026-05-05 |
| TCG Crossover Management, LLC | Institution | 3.017.120 | 5,74% | US$ 60,22M | 2026-05-05 |
| Point72 Associates, LLC | Institution | 2.710.817 | 5,16% | US$ 54,11M | 2026-05-22 |
| Point72 Asset Management, L.P. | Institution | 2.710.817 | 5,16% | US$ 54,11M | 2026-05-22 |
| BVF Partners L.P. | Institution | 2.677.385 | 5,09% | US$ 53,44M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 2.162.684 | 4,11% | US$ 43,17M | 2026-03-31 |
| Caligan Partners, LP | Institution | 1.635.023 | 3,11% | US$ 32,64M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 1.447.651 | 2,75% | US$ 28,90M | 2026-03-31 |
| Avoro Life Sciences Fund LLC | Institution | 1.410.000 | 2,68% | US$ 28,14M | 2026-03-31 |
| Avoro Capital Advisors LLC | Institution | 1.410.000 | 2,68% | US$ 28,14M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 1.340.840 | 2,55% | US$ 26,76M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 1.235.000 | 2,35% | US$ 24,65M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.141.980 | 2,17% | US$ 22,79M | 2026-03-31 |
| Affinity Healthcare Fund, LP | Institution | 1.051.054 | 2,00% | US$ 20,98M | 2026-01-22 |
| Biotechnology Value Fund II, L.P. | Institution | 1.035.952 | 1,97% | US$ 20,68M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 1.018.319 | 1,94% | US$ 20,33M | 2026-06-11 |
| Commodore Capital LP | Institution | 1.018.319 | 1,94% | US$ 20,33M | 2026-06-11 |
| Farallon Capital Management, L.L.C. | Institution | 916.000 | 1,74% | US$ 18,28M | 2026-03-31 |
| RTW Investments, LP | Institution | 856.962 | 1,63% | US$ 17,10M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 854.000 | 1,62% | US$ 17,05M | 2026-03-31 |
| Millennium Management LLC | Institution | 835.484 | 1,59% | US$ 16,68M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 731.586 | 1,39% | US$ 14,60M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 719.694 | 1,37% | US$ 14,37M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 675.000 | 1,28% | US$ 13,47M | 2026-03-31 |
| Logos Global Master Fund, LP | Institution | 675.000 | 1,28% | US$ 13,47M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 662.968 | 1,26% | US$ 13,23M | 2026-03-31 |
| Bank of America Corporation | Institution | 643.000 | 1,22% | US$ 12,83M | 2026-03-31 |
| Seven Fleet Capital Management LP | Institution | 573.883 | 1,09% | US$ 11,45M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 475.165 | 0,90% | US$ 9,48M | 2026-03-31 |
| Jennison Associates LLC | Institution | 470.775 | 0,90% | US$ 9,40M | 2026-03-31 |
| Caption Management, LLC | Institution | 455.000 | 0,87% | US$ 9,08M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 441.978 | 0,84% | US$ 8,82M | 2026-03-31 |
| Atlas Diversified Master Fund, Ltd. | Institution | 439.312 | 0,84% | US$ 8,77M | 2025-12-31 |
| BNP Paribas Financial Markets SNC | Institution | 422.781 | 0,80% | US$ 8,44M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 404.163 | 0,77% | US$ 8,07M | 2026-05-31 |
| Kennedy Capital Management LLC | Institution | 387.982 | 0,74% | US$ 7,74M | 2026-03-31 |
| Dv Trading, LLC | Institution | 360.064 | 0,68% | US$ 7,19M | 2026-03-31 |
| BlackRock, Inc. | Institution | 327.082 | 0,62% | US$ 6,53M | 2026-03-31 |