| L1 Capital Pty. Limited | Institution | 21.008.814 | 21,58% | US$ 218,49M | 2026-03-31 |
| Medtronic plc | Institution | 15.652.173 | 16,08% | US$ 162,78M | 2026-01-22 |
| BlackRock, Inc. | Institution | 9.768.221 | 10,03% | US$ 101,59M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 7.155.566 | 7,35% | US$ 74,42M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 5.530.910 | 5,68% | US$ 57,52M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 5.130.606 | 5,27% | US$ 53,36M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 3.789.132 | 3,89% | US$ 39,41M | 2026-03-31 |
| FMR LLC | Institution | 3.369.926 | 3,46% | US$ 35,05M | 2026-03-31 |
| BVF Partners L.P. | Institution | 3.000.000 | 3,08% | US$ 31,20M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 3.000.000 | 3,08% | US$ 31,20M | 2026-03-31 |
| Ensign Peak Advisors, Inc. | Institution | 2.087.111 | 2,14% | US$ 21,71M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.841.230 | 1,89% | US$ 19,15M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 1.705.130 | 1,75% | US$ 17,73M | 2025-06-30 |
| Rhenman & Partners Asset Management AB | Institution | 1.438.625 | 1,48% | US$ 14,96M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.406.836 | 1,45% | US$ 14,63M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.223.107 | 1,26% | US$ 12,72M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 1.144.780 | 1,18% | US$ 11,91M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 912.397 | 0,94% | US$ 9,49M | 2026-03-31 |
| Oasis Management Company Ltd. | Institution | 865.565 | 0,89% | US$ 9,00M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 857.803 | 0,88% | US$ 8,92M | 2026-03-31 |
| Suvretta Capital Management, LLC | Institution | 850.000 | 0,87% | US$ 8,84M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 750.000 | 0,77% | US$ 7,80M | 2026-03-31 |
| Velan Capital Partners LP | Institution | 700.000 | 0,72% | US$ 7,28M | 2026-03-31 |
| Militia Capital Management, LLC | Institution | 660.000 | 0,68% | US$ 6,86M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 653.330 | 0,67% | US$ 6,79M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 591.046 | 0,61% | US$ 6,15M | 2026-03-31 |
| Capricorn Fund Managers (Pty) Ltd. | Institution | 500.525 | 0,51% | US$ 5,21M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 481.224 | 0,49% | US$ 5,00M | 2026-04-30 |
| Vanguard Fiduciary Trust Company | Institution | 476.344 | 0,49% | US$ 4,95M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 469.583 | 0,48% | US$ 4,88M | 2026-03-31 |
| LMR Partners LLP | Institution | 450.000 | 0,46% | US$ 4,68M | 2026-03-31 |
| Mr. Wayne Paterson | Insider | 406.122 | 0,42% | US$ 4,22M | 2026-02-25 |
| GSCO - ECA Resource Geologic Partners | Institution | 403.250 | 0,41% | US$ 4,19M | 2025-01-31 |
| Eversept Partners, L.P. | Institution | 401.187 | 0,41% | US$ 4,17M | 2026-03-31 |
| Woodline Partners LP | Institution | 400.000 | 0,41% | US$ 4,16M | 2026-03-31 |
| Mr. Patrick Chew | Insider | 390.797 | 0,40% | US$ 4,06M | 2025-01-31 |
| The Goldman Sachs Group, Inc. | Institution | 378.649 | 0,39% | US$ 3,94M | 2026-03-31 |
| Mr. Ricky Neumann | Insider | 372.698 | 0,38% | US$ 3,88M | 2025-01-31 |
| Ikarian Capital, LLC | Institution | 366.571 | 0,38% | US$ 3,81M | 2026-03-31 |
| Hunter Capital Advisors Pty Ltd | Institution | 329.767 | 0,34% | US$ 3,43M | 2025-01-31 |