| EcoR1 Capital, LLC | Institution | 7.880.094 | 27,08% | US$ 515,59M | 2026-03-31 |
| Ecor1 Capital Fund Qualified, L.P. | Institution | 7.401.972 | 25,44% | US$ 484,31M | 2025-01-02 |
| BlackRock, Inc. | Institution | 1.681.380 | 5,78% | US$ 110,01M | 2026-03-31 |
| Tang Capital Management, LLC | Institution | 1.330.879 | 4,57% | US$ 87,08M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 992.445 | 3,41% | US$ 64,94M | 2026-03-31 |
| Morgan Stanley | Institution | 961.084 | 3,30% | US$ 62,88M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 940.000 | 3,23% | US$ 61,50M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 853.151 | 2,93% | US$ 55,82M | 2026-03-31 |
| Sanofi | Institution | 821.917 | 2,82% | US$ 53,78M | 2026-03-31 |
| Frazier Healthcare VII, L.P. | Institution | 640.903 | 2,20% | US$ 41,93M | 2024-12-31 |
| Palo Alto Investors LP | Institution | 638.161 | 2,19% | US$ 41,75M | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 625.000 | 2,15% | US$ 40,89M | 2026-03-31 |
| Frazier Life Sciences Public Fund, L.P. | Institution | 612.503 | 2,10% | US$ 40,08M | 2024-12-31 |
| D. E. Shaw & Co., L.P. | Institution | 579.296 | 1,99% | US$ 37,90M | 2026-03-31 |
| First Light Asset Management, LLC | Institution | 565.431 | 1,94% | US$ 37,00M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 520.241 | 1,79% | US$ 34,04M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 519.870 | 1,79% | US$ 34,02M | 2026-03-31 |
| Bank of America Corporation | Institution | 501.086 | 1,72% | US$ 32,79M | 2026-03-31 |
| Mr. Daniel Faga | Insider | 496.684 | 1,71% | US$ 32,50M | 2026-04-01 |
| Arrowstreet Capital, Limited Partnership | Institution | 492.120 | 1,69% | US$ 32,20M | 2026-03-31 |
| Millennium Management LLC | Institution | 475.572 | 1,63% | US$ 31,12M | 2026-03-31 |
| FMR LLC | Institution | 472.011 | 1,62% | US$ 30,88M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 465.083 | 1,60% | US$ 30,43M | 2026-03-31 |
| Federated Hermes, Inc. | Institution | 364.121 | 1,25% | US$ 23,82M | 2026-03-31 |
| Woodline Partners LP | Institution | 344.256 | 1,18% | US$ 22,52M | 2026-03-31 |
| Synergy Asset Management, LLC | Institution | 317.106 | 1,09% | US$ 20,75M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 313.224 | 1,08% | US$ 20,49M | 2026-03-31 |
| Squarepoint OPS LLC | Institution | 267.703 | 0,92% | US$ 17,52M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 254.736 | 0,88% | US$ 16,67M | 2026-03-31 |
| Sofinnova Investments, Inc. | Institution | 248.253 | 0,85% | US$ 16,24M | 2026-03-31 |
| Apis Capital Advisors, LLC | Institution | 238.000 | 0,82% | US$ 15,57M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 233.450 | 0,80% | US$ 15,27M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 192.687 | 0,66% | US$ 12,61M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 183.519 | 0,63% | US$ 12,01M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 169.514 | 0,58% | US$ 11,09M | 2026-03-31 |
| Frazier Life Sciences XI, L.P. | Institution | 165.521 | 0,57% | US$ 10,83M | 2024-12-31 |
| The Goldman Sachs Group, Inc. | Institution | 163.229 | 0,56% | US$ 10,68M | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 158.562 | 0,54% | US$ 10,37M | 2026-03-31 |