| BlackRock, Inc. | Institution | 28.314.002 | 16,99% | US$ 1,56B | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 10.012.267 | 6,01% | US$ 551,48M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 9.511.112 | 5,71% | US$ 523,87M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 9.465.286 | 5,68% | US$ 521,35M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 7.427.397 | 4,46% | US$ 409,10M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 6.160.428 | 3,70% | US$ 339,32M | 2026-03-31 |
| American Century Investment Management Inc | Institution | 6.072.103 | 3,64% | US$ 334,45M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 5.558.852 | 3,34% | US$ 306,18M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 4.522.378 | 2,71% | US$ 249,09M | 2026-03-31 |
| Commodore Capital LP | Institution | 4.200.000 | 2,52% | US$ 231,34M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 4.182.267 | 2,51% | US$ 230,36M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 3.963.494 | 2,38% | US$ 218,31M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 3.590.323 | 2,15% | US$ 197,75M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 2.970.166 | 1,78% | US$ 163,60M | 2026-03-31 |
| First Trust Advisors LP | Institution | 2.968.785 | 1,78% | US$ 163,52M | 2026-03-31 |
| PRIMECAP Management Company | Institution | 2.539.990 | 1,52% | US$ 139,90M | 2026-03-31 |
| Holocene Advisors, LP | Institution | 2.317.326 | 1,39% | US$ 127,64M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 2.241.584 | 1,34% | US$ 123,47M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 2.236.782 | 1,34% | US$ 123,20M | 2026-03-31 |
| BVF Partners L.P. | Institution | 2.000.000 | 1,20% | US$ 110,16M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 1.970.864 | 1,18% | US$ 108,56M | 2026-03-31 |
| Norges Bank Investment Management | Institution | 1.945.734 | 1,17% | US$ 107,17M | 2025-12-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 1.858.203 | 1,11% | US$ 102,35M | 2026-03-31 |
| Loomis, Sayles & Company, L.P. | Institution | 1.784.581 | 1,07% | US$ 98,29M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.697.082 | 1,02% | US$ 93,48M | 2026-03-31 |
| RTW Investments, LP | Institution | 1.672.356 | 1,00% | US$ 92,11M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 1.350.000 | 0,81% | US$ 74,36M | 2026-03-31 |
| FMR LLC | Institution | 1.320.537 | 0,79% | US$ 72,74M | 2026-03-31 |
| Avoro Capital Advisors LLC | Institution | 1.200.000 | 0,72% | US$ 66,10M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 1.129.236 | 0,68% | US$ 62,20M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 1.111.741 | 0,67% | US$ 61,23M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 1.060.178 | 0,64% | US$ 58,39M | 2026-03-31 |