| Woodline Master Fund LP | Institution | 468.199 | 7,57% | US$ 2,50M | 2025-09-30 |
| Deep Track Capital, LP | Institution | 444.110 | 7,18% | US$ 2,37M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 444.110 | 7,18% | US$ 2,37M | 2025-03-06 |
| Roche Holding AG | Institution | 441.037 | 7,13% | US$ 2,36M | 2025-03-06 |
| Alyeska Investment Group, L.P. | Institution | 412.000 | 6,66% | US$ 2,20M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 327.237 | 5,29% | US$ 1,75M | 2026-03-31 |
| Marshall Wace LLP | Institution | 267.135 | 4,32% | US$ 1,43M | 2026-03-31 |
| Bank of America Corporation | Institution | 229.754 | 3,71% | US$ 1,23M | 2026-03-31 |
| Armistice Capital LLC | Institution | 188.438 | 3,05% | US$ 1,01M | 2024-12-31 |
| Armistice Capital Master Fund Ltd. | Institution | 188.438 | 3,05% | US$ 1,01M | 2024-12-31 |
| Vanguard Capital Management, LLC | Institution | 178.262 | 2,88% | US$ 951,92k | 2026-03-31 |
| Woodline Partners LP | Institution | 177.362 | 2,87% | US$ 947,11k | 2026-03-31 |
| Crestline Investors Inc. | Institution | 148.799 | 2,40% | US$ 794,59k | 2026-03-31 |
| Ics Opportunities II Llc | Institution | 123.872 | 2,00% | US$ 661,48k | 2024-09-09 |
| Renaissance Technologies LLC | Institution | 100.450 | 1,62% | US$ 536,40k | 2026-03-31 |
| Dr. Lawrence Blatt | Insider | 88.416 | 1,43% | US$ 472,14k | 2026-03-31 |
| Ecor1 Capital Fund Qualified, L.P. | Institution | 83.807 | 1,35% | US$ 447,53k | 2025-03-31 |
| Baker Bros. Advisors LP | Institution | 83.055 | 1,34% | US$ 443,51k | 2026-03-31 |
| Hillhouse Investment Management, Ltd. | Institution | 76.247 | 1,23% | US$ 407,16k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 54.311 | 0,88% | US$ 290,02k | 2026-03-31 |
| LPL Financial LLC | Institution | 51.500 | 0,83% | US$ 275,01k | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 49.975 | 0,81% | US$ 266,87k | 2026-03-31 |
| UBS Asset Management AG | Institution | 37.061 | 0,60% | US$ 197,91k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 28.437 | 0,46% | US$ 151,85k | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 23.093 | 0,37% | US$ 123,32k | 2026-03-31 |
| Verition Fund Management LLC | Institution | 18.887 | 0,31% | US$ 100,86k | 2026-03-31 |
| Dr. Julian Symons | Insider | 15.762 | 0,25% | US$ 84,17k | 2025-03-06 |
| XTX Markets Limited | Institution | 14.196 | 0,23% | US$ 75,81k | 2026-03-31 |
| BlackRock, Inc. | Institution | 13.040 | 0,21% | US$ 69,63k | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 10.978 | 0,18% | US$ 58,62k | 2026-03-31 |
| Quadrature Capital Limited | Institution | 10.822 | 0,17% | US$ 57,79k | 2026-03-31 |
| Rockefeller & Co. LLC | Institution | 10.000 | 0,16% | US$ 53,40k | 2026-03-31 |
| Mr. James Scopa | Insider | 7.323 | 0,12% | US$ 39,10k | 2025-03-06 |
| Dimensional Fund Advisors LP | Institution | 5.519 | 0,09% | US$ 29,47k | 2026-04-30 |
| Ms. Lesley Calhoun | Insider | 3.607 | 0,06% | US$ 19,26k | 2025-03-06 |
| Golden State Wealth Management, LLC | Institution | 2.674 | 0,04% | US$ 14,28k | 2026-03-31 |
| Dr. K. Hirth | Insider | 2.380 | 0,04% | US$ 12,71k | 2025-03-06 |
| RBC Dominion Securities Inc. | Institution | 2.125 | 0,03% | US$ 11,35k | 2026-03-31 |
| American Century Investment Management Inc | Institution | 1.759 | 0,03% | US$ 9,39k | 2026-04-30 |