By Robert McMillan 

As Hewlett-Packard inches toward its Nov. 1 breakup, one of the people leading the charge is on his way out. Bill Veghte, the head of H-P's business-centric Enterprise Group, is leaving the company to "pursue a new opportunity," H-P said Tuesday.

Mr. Veghte, who couldn't be reached for comment, said in a recent interview that he had two objectives: running the enterprise business and facilitating H-P's split into two separate companies.

"If the enterprise business is healthy and separation is proceeding smoothly, then it's great. And if it's not, then I've got to get on it," he said.

Mr. Veghte's departure comes as H-P struggles to turn around its enterprise business, which saw revenue decline 1% year-over-year during its most-recent quarter.

"You're talking about a company that's going through seismic changes," said Daniel Ives, an analyst with FBR & Co. "I view it as just another sign that large tech players like H-P need to find success in the cloud."

H-P expects to file documents with the Securities and Exchange Commission later this week detailing its division. The split will create two $57 billion offshoots: the printer-and-PC seller HP Inc. and the corporate-technology behemoth Hewlett Packard Enterprise.

A former Microsoft executive who played a key role in the launch of Windows 7, Mr. Veghte was hired by Mark Hurd in 2010 to build H-P's software business. Chief Executive Meg Whitman, just months after taking the helm at H-P in September, 2011, elevated Mr. Veghte to the role of chief operating officer before putting him in charge of the Enterprise Group. Ultimately, she gave him a key role in plotting H-P's separation strategy.

Twenty-year H-P veteran Antonio Neri will take over the company's enterprise business. The separation effort will now fall on the shoulders of Chris Hsu, a private-equity turnaround specialist hired by Ms. Whitman in early 2014. Mr. Hsu had already been pegged to manage the breakup's day-to-day tactics. After the split, he will be the chief operating officer within Hewlett Packard Enterprise.

In H-P's statement, Mr. Veghte praised Mr. Hsu and Mr. Neri. "HP is equipped to take the business to new heights with great leaders like Antonio Neri and Chris Hsu and the progress we have made over the last 4 years," he said.

Write to Robert McMillan at Robert.Mcmillan@wsj.com

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