| RA Capital Management, L.P. | Institution | 26.975.505 | 14,02% | US$ 156,73M | 2026-04-15 |
| RA Capital Healthcare Fund, L.P. | Institution | 26.975.505 | 14,02% | US$ 156,73M | 2026-04-15 |
| GSK Equity Investments, Limited | Institution | 18.245.691 | 9,48% | US$ 106,01M | 2026-03-31 |
| BlackRock, Inc. | Institution | 14.117.374 | 7,34% | US$ 82,02M | 2026-03-31 |
| Maverick Capital, Ltd. | Institution | 10.161.399 | 5,28% | US$ 59,04M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 8.704.550 | 4,52% | US$ 50,57M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 5.431.021 | 2,82% | US$ 31,55M | 2026-03-31 |
| Federated Hermes, Inc. | Institution | 5.317.457 | 2,76% | US$ 30,89M | 2026-03-31 |
| FMR LLC | Institution | 5.192.690 | 2,70% | US$ 30,17M | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 4.900.000 | 2,55% | US$ 28,47M | 2026-03-31 |
| PRIMECAP Management Company | Institution | 4.832.952 | 2,51% | US$ 28,08M | 2026-03-31 |
| M28 Capital Management LP | Institution | 4.588.284 | 2,38% | US$ 26,66M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 3.674.033 | 1,91% | US$ 21,35M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 3.579.099 | 1,86% | US$ 20,79M | 2026-03-31 |
| Artal Group S.A. | Institution | 2.450.000 | 1,27% | US$ 14,23M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 2.202.856 | 1,14% | US$ 12,80M | 2026-03-31 |
| Emerald Advisers, LLC | Institution | 2.075.712 | 1,08% | US$ 12,06M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.878.115 | 0,98% | US$ 10,91M | 2026-03-31 |
| Pfizer Venture Investments LLC | Institution | 1.875.000 | 0,97% | US$ 10,89M | 2026-03-31 |
| First Light Asset Management, LLC | Institution | 1.843.968 | 0,96% | US$ 10,71M | 2026-03-31 |
| Marshall Wace LLP | Institution | 1.789.882 | 0,93% | US$ 10,40M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.611.853 | 0,84% | US$ 9,36M | 2026-03-31 |
| Squarepoint OPS LLC | Institution | 1.462.390 | 0,76% | US$ 8,50M | 2026-03-31 |
| Schroder Investment Management Limited | Institution | 1.441.059 | 0,75% | US$ 8,37M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 1.401.727 | 0,73% | US$ 8,14M | 2026-03-31 |
| RTW Investments, LP | Institution | 1.350.000 | 0,70% | US$ 7,84M | 2026-03-31 |
| Algert Global LLC | Institution | 1.315.589 | 0,68% | US$ 7,64M | 2026-03-31 |
| Morgan Stanley | Institution | 1.303.930 | 0,68% | US$ 7,58M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.189.230 | 0,62% | US$ 6,91M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 1.179.279 | 0,61% | US$ 6,85M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.176.207 | 0,61% | US$ 6,83M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 1.149.127 | 0,60% | US$ 6,68M | 2026-03-31 |
| Trexquant Investment LP | Institution | 1.089.642 | 0,57% | US$ 6,33M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 1.000.000 | 0,52% | US$ 5,81M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 1.000.000 | 0,52% | US$ 5,81M | 2026-03-31 |
| Millennium Management LLC | Institution | 972.241 | 0,51% | US$ 5,65M | 2026-03-31 |
| Kynam Capital Management, LP | Institution | 965.193 | 0,50% | US$ 5,61M | 2026-03-31 |