| Acuta Capital Partners, LLC | Institution | 4.685.912 | 9,48% | US$ 19,21M | 2026-05-14 |
| QVT Financial LP | Institution | 4.615.709 | 9,33% | US$ 18,92M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 4.166.000 | 8,42% | US$ 17,08M | 2026-03-31 |
| Suvretta Capital Management, LLC | Institution | 3.700.000 | 7,48% | US$ 15,17M | 2026-03-31 |
| Longwood Capital, LP | Institution | 3.538.288 | 7,15% | US$ 14,51M | 2026-05-14 |
| Avoro Capital Advisors LLC | Institution | 3.471.752 | 7,02% | US$ 14,23M | 2026-05-12 |
| Ally Bridge Group | Institution | 2.887.939 | 5,84% | US$ 11,84M | 2026-03-31 |
| Coastlands Capital LP | Institution | 2.819.215 | 5,70% | US$ 11,56M | 2026-04-17 |
| Coastlands Capital Partners LP | Institution | 2.819.215 | 5,70% | US$ 11,56M | 2025-08-19 |
| KVP Capital, LP | Institution | 2.165.998 | 4,38% | US$ 8,88M | 2026-05-14 |
| Kvp Capital Advisors, LP | Institution | 2.165.998 | 4,38% | US$ 8,88M | 2026-05-14 |
| Artal Group S.A. | Institution | 2.082.000 | 4,21% | US$ 8,54M | 2026-03-31 |
| BML Investment Partners, L.P. | Institution | 1.971.137 | 3,99% | US$ 8,08M | 2025-03-05 |
| Dr. Neil Desai | Insider | 1.811.241 | 3,66% | US$ 7,43M | 2026-04-17 |
| Vanguard Capital Management, LLC | Institution | 1.315.770 | 2,66% | US$ 5,39M | 2026-03-31 |
| Dr. Baiteng Zhao | Insider | 1.250.000 | 2,53% | US$ 5,13M | 2026-04-17 |
| Acuta Opportunity Fund, LP | Institution | 1.147.624 | 2,32% | US$ 4,71M | 2026-05-14 |
| Acorn Bioventures | Institution | 1.139.363 | 2,30% | US$ 4,67M | 2026-03-31 |
| StemPoint Capital LP | Institution | 939.369 | 1,90% | US$ 3,85M | 2026-03-31 |
| Ally Bridge MedAlpha Master Fund L.P. | Institution | 817.939 | 1,65% | US$ 3,35M | 2025-03-04 |
| Avoro Ventures Fund L.P. | Institution | 622.350 | 1,26% | US$ 2,55M | 2025-02-28 |
| Dr. David Lennon | Insider | 569.643 | 1,15% | US$ 2,34M | 2026-05-14 |
| Balyasny Asset Management L.P. | Institution | 550.441 | 1,11% | US$ 2,26M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 457.540 | 0,93% | US$ 1,88M | 2026-03-31 |
| Mr. Bryan Ball | Insider | 448.126 | 0,91% | US$ 1,84M | 2026-05-14 |
| Renaissance Technologies LLC | Institution | 428.622 | 0,87% | US$ 1,76M | 2026-03-31 |
| BlackRock, Inc. | Institution | 351.385 | 0,71% | US$ 1,44M | 2026-03-31 |
| Mr. Braden Leonard | Insider | 335.000 | 0,68% | US$ 1,37M | 2025-03-05 |
| Mr. Scott Giacobello | Insider | 333.489 | 0,67% | US$ 1,37M | 2026-05-14 |
| Ecor1 Capital Fund Qualified, L.P. | Institution | 324.365 | 0,66% | US$ 1,33M | 2024-12-31 |
| Millennium Management LLC | Institution | 309.674 | 0,63% | US$ 1,27M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 306.800 | 0,62% | US$ 1,26M | 2026-03-31 |
| Woodline Partners LP | Institution | 281.497 | 0,57% | US$ 1,15M | 2026-03-31 |
| Mr. Caley Castelein | Insider | 274.796 | 0,56% | US$ 1,13M | 2026-05-14 |
| Two Sigma Investments, LP | Institution | 273.482 | 0,55% | US$ 1,12M | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 215.284 | 0,44% | US$ 882,66k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 214.827 | 0,43% | US$ 880,79k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 203.465 | 0,41% | US$ 834,21k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 160.382 | 0,32% | US$ 657,57k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 151.110 | 0,31% | US$ 619,55k | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 128.503 | 0,26% | US$ 526,86k | 2026-03-31 |
| Verdad Advisers, L.P. | Institution | 115.484 | 0,23% | US$ 473,48k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 107.266 | 0,22% | US$ 439,79k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 91.852 | 0,19% | US$ 376,59k | 2026-03-31 |