| Acuta Capital Partners, LLC | Institution | 4.685.912 | 8,71% | US$ 18,09M | 2026-05-14 |
| QVT Financial LP | Institution | 4.615.709 | 8,58% | US$ 17,82M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 4.166.000 | 7,75% | US$ 16,08M | 2026-03-31 |
| Suvretta Capital Management, LLC | Institution | 3.700.000 | 6,88% | US$ 14,28M | 2026-03-31 |
| Longwood Capital, LP | Institution | 3.538.288 | 6,58% | US$ 13,66M | 2026-05-14 |
| Avoro Capital Advisors LLC | Institution | 3.471.752 | 6,46% | US$ 13,40M | 2026-05-12 |
| Ally Bridge Group | Institution | 2.887.939 | 5,37% | US$ 11,15M | 2026-03-31 |
| Kvp Capital Advisors, LP | Institution | 2.165.998 | 4,03% | US$ 8,36M | 2026-05-14 |
| Artal Group S.A. | Institution | 2.082.000 | 3,87% | US$ 8,04M | 2026-03-31 |
| BML Investment Partners, L.P. | Institution | 1.971.137 | 3,66% | US$ 7,61M | 2025-03-05 |
| Vanguard Capital Management, LLC | Institution | 1.315.770 | 2,45% | US$ 5,08M | 2026-03-31 |
| Acuta Opportunity Fund, LP | Institution | 1.147.624 | 2,13% | US$ 4,43M | 2026-05-14 |
| Acorn Bioventures | Institution | 1.139.363 | 2,12% | US$ 4,40M | 2026-03-31 |
| StemPoint Capital LP | Institution | 939.369 | 1,75% | US$ 3,63M | 2026-03-31 |
| Ally Bridge MedAlpha Master Fund L.P. | Institution | 817.939 | 1,52% | US$ 3,16M | 2025-03-04 |
| Avoro Ventures Fund L.P. | Institution | 622.350 | 1,16% | US$ 2,40M | 2025-02-28 |
| Dr. David Lennon | Insider | 569.643 | 1,06% | US$ 2,20M | 2026-05-14 |
| Balyasny Asset Management L.P. | Institution | 550.441 | 1,02% | US$ 2,12M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 457.540 | 0,85% | US$ 1,77M | 2026-03-31 |
| Mr. Bryan Ball | Insider | 448.126 | 0,83% | US$ 1,73M | 2026-05-14 |
| Renaissance Technologies LLC | Institution | 428.622 | 0,80% | US$ 1,65M | 2026-03-31 |
| BlackRock, Inc. | Institution | 351.385 | 0,65% | US$ 1,36M | 2026-03-31 |
| Mr. Scott Giacobello | Insider | 333.489 | 0,62% | US$ 1,29M | 2026-05-14 |
| Ecor1 Capital Fund Qualified, L.P. | Institution | 324.365 | 0,60% | US$ 1,25M | 2024-12-31 |
| Millennium Management LLC | Institution | 309.674 | 0,58% | US$ 1,20M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 306.800 | 0,57% | US$ 1,18M | 2026-03-31 |
| Woodline Partners LP | Institution | 281.497 | 0,52% | US$ 1,09M | 2026-03-31 |
| Mr. Caley Castelein | Insider | 274.796 | 0,51% | US$ 1,06M | 2026-05-14 |
| Two Sigma Investments, LP | Institution | 273.482 | 0,51% | US$ 1,06M | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 215.284 | 0,40% | US$ 831,00k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 214.827 | 0,40% | US$ 829,23k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 203.465 | 0,38% | US$ 785,37k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 160.382 | 0,30% | US$ 619,07k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 151.110 | 0,28% | US$ 583,28k | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 128.503 | 0,24% | US$ 496,02k | 2026-03-31 |
| Verdad Advisers, L.P. | Institution | 115.484 | 0,21% | US$ 445,77k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 107.266 | 0,20% | US$ 414,05k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 91.852 | 0,17% | US$ 354,55k | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 70.101 | 0,13% | US$ 270,59k | 2026-03-31 |
| Hudson Bay Capital Management LP | Institution | 57.597 | 0,11% | US$ 222,32k | 2026-03-31 |